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Matches 1 - 50 out of 30,545

Document Document Title
WO/2024/039689A1
Provided herein are compounds of formula (I) that modulate RMB39 and methods of using the compounds in RMB39-associated disorders, such as cancer (e.g., renal cell carcinoma).  
WO/2024/038282A1
The present invention provides compounds of formula (I): Formula (I) compositions comprising such compounds; the use of such compounds in medicine; and methods of treating patients with such compounds; wherein A, W, V, Z, Y and B are as ...  
WO/2024/040190A1
Provided are compounds of Formula (I). Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formu...  
WO/2024/040155A1
Disclosed herein are isoxazolidine compounds and their use as receptor-interacting protein kinase 1 inhibitor, for example in the treatment of diseases and disorders mediated by RIP kinase 1.  
WO/2024/040267A2
The present disclosure is directed to N-(3-substituted-chroman-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4- amine compounds useful as PINK1 modulators, compounds useful in preparing N-(3-substituted-chroman-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4- ami...  
WO/2024/039056A1
The present invention provides: a compound represented by chemical formula 1; an organic electric element comprising a first electrode, a second electrode, and an organic material layer between the first electrode and the second electrod...  
WO/2024/039886A1
Benzazepine derivatives of Formula (I), compositions comprising therapeutically effective amounts of those benzazepine derivatives and methods of using those derivatives or compositions in treating cognitive impairment associated with ce...  
WO/2024/039250A1
The present invention relates to a new class of methanogen inhibitors for ruminants. The invention also extends to the use of such compounds in ruminants to reduce methane production in the rumen and/or to enhance productivity in the rum...  
WO/2024/034657A1
The present invention addresses the problem of providing a pharmaceutical composition for cancer treatment of colorectal cancer and/or lung cancer. The present inventors have studied compounds useful as an active ingredient for a pharm...  
WO/2024/032529A1
Provided are a protein degradation agent and a preparation method therefor and a pharmaceutical use thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method therefor, a ...  
WO/2024/035950A1
Provided are compounds of the Formula (I), or pharmaceutically acceptable salts thereof, which are useful for the inhibition of KIF18A and in the treatment of a variety of KIF18A mediated conditions or diseases, such as cancer.  
WO/2024/036176A1
Provided herein are heterocyclic compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting the growth of gram-negative bacteria. The subject compounds and compositions are useful for the treatment...  
WO/2024/032501A1
Provided are a compound of formula 0, a stereoisomer thereof, a tautomer thereof, a geometric isomer thereof, an enantiomer thereof, a diastereomer thereof, a racemate thereof, a polymorph thereof, a solvate thereof, a hydrate thereof, a...  
WO/2024/032715A1
Disclosed is a compound having a structure represented by formula (I). The compound has excellent antiviral activity against orthopoxvirus, has multiple advantages compared with a marketed drug Tecovirimat, and has important development ...  
WO/2024/032584A1
The present invention relates to a protein tyrosine kinase inhibitor for treating protein tyrosine kinase-mediated proliferative diseases or symptoms, such as ocular diseases and malignant tumors accompanied by pathological neoangiogenes...  
WO/2024/031089A1
The present disclosure relates to compounds of Formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.  
WO/2024/027795A1
An antibody-drug conjugate containing an Myc protein degradation agent bioactive compound, a preparation method therefor, and use thereof in preventing and/or treating diseases related to abnormal cell activity, including but not limited...  
WO/2024/027703A1
Provided are a PRMT5 inhibitor, and a preparation method therefor and a use thereof. Specifically disclosed are a compound as shown in formula I, a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, and a use thereof in ...  
WO/2024/027694A1
The present invention relates to a protein degradation agent, a preparation method therefor, and a use thereof. The protein degradation agent can degrade various proteins including c-Myc protein, and therefore can be used for prevention ...  
WO/2024/026536A1
The present disclosure relates to a compound of formula (I), or an N-oxide, pharmaceutically acceptable salt, prodrug or stereoisomer thereof. The present disclosure also relates to pharmaceutical compositions comprising the compound. Th...  
WO/2024/027767A1
The present invention relates to a herbicide composition comprising a uracil compound comprising at least one carboxylate fragment represented by formula (I) and at least one herbicide active compound, and a use of the herbicide composit...  
WO/2024/027641A1
An IRAK4 inhibitor composition, a preparation method therefor and use thereof. The composition comprises: (i) a compound of formula I, a stereoisomer, a solvate or a pharmaceutically acceptable salt thereof; (ii) a diluent; (iii) a disin...  
WO/2024/028795A1
The present invention discloses novel compounds as defined by the general formula (I) that are useful for the treatment of diabetes mellitus, obesity, body weight reduction, insulin resistance etc. involving the agonism of the glucagon l...  
WO/2023/235305A3
The invention provides novel sulfonyl cyclic derivatives, and compositions and methods of preparation and use thereof, that are useful in treating various diseases and disorders related to TRPML activities such as lysosome storage diseas...  
WO/2024/028604A1
The present invention relates to compounds of formula (I) as prostaglandin E2 receptor 4 (EP4) agonists for use in methods of treatment of gastrointestinal and pulmonary diseases or disorders. The present disclosure provides exemplary co...  
WO/2024/029638A1
The present invention relates to a series of novel heterocyclyl-phenyl-methylamine derivatives, a preparation method therefor, and a use thereof for prevention, alleviation, or treatment of multiple sclerosis.  
WO/2024/028605A1
The invention relates to a class of ortho-substituted difunctional benzoxazine compounds useful as curatives, as well as methods of preparation, and uses thereof. The ortho-substituted difunctional benzoxazine compounds comprise two benz...  
WO/2024/029583A1
The present invention relates to: a compound represented by formula (I) (wherein Ar1 and Ar2 may be the same as or different from each other, and each represent a substituted or unsubstituted aromatic group; L1 represents a direct bond o...  
WO/2024/028365A1
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of GPR84, and the treatment of GPR84-mediated disorders.  
WO/2024/027800A1
The present invention relates to a new compound as a 5-HT2A receptor inverse agonist, a preparation method therefor and a pharmaceutical composition. The present invention further relates to the use of the compound or the pharmaceutical ...  
WO/2024/029613A1
Provided is a compound useful as an active ingredient in a pharmaceutical composition for treating pancreatic cancer. The present inventors carried out investigations with regard to compounds useful as an active ingredient in a pharmac...  
WO/2024/030651A1
The present disclosure provides a compound of Formula (I'), or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which inhibiting GPX4 in a subject is of therapeutic benefit, sp...  
WO/2024/023128A1
The invention relates to novel compounds having the general formula (I), wherein R1, R2, R3, R4, R5 and R6 are as described herein, composition including the compounds and methods of using the compounds.  
WO/2024/023287A1
The present invention relates to a compound of general formula (I). The invention further relates to the compounds of the invention as neuroprotective and/or neurorestorative agents, in particular for use in the treatment of neurological...  
WO/2023/185468A9
The present invention belongs to the field of synthesis of heterocyclic compound drugs with a nitrogen atom as a heterocyclic atom; particularly relates to a compound used as a kinase inhibitor and the use thereof; and also relates to th...  
WO/2024/026359A1
In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds that are inhibitors for thioredoxin glutathione reductase (TGR), which is key for ...  
WO/2024/026484A2
The present disclosure provides compounds, compositions thereof, and methods of using the same for the inhibition of CDK2, and the treatment of CDK2 related diseases and disorders.  
WO/2024/022481A1
The present invention belongs to the technical field of medicines. Disclosed are phenyl-substituted dihydronaphthyridine compounds and preparation and use thereof. The compound disclosed by the present invention is represented by formula...  
WO/2024/022294A1
Disclosed are a spirochiral platinum(ii) and palladium(ii) complex circularly polarized luminescent material, and a use thereof. The formation of the spirochiral metal complex molecule can autonomously induce an entire tetradentate ligan...  
WO/2024/026061A1
The present disclosure provides a compound of Formula (I'), or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which lowering mutant huntingtin protein ("mHTT") in a subject i...  
WO/2024/022475A1
The present invention belongs to the technical field of pharmaceutical synthesis technology and relates to a pyridyl-substituted thioglycolide intermediate for pharmaceutical use and its preparation method and use. In particular, the pre...  
WO/2024/026072A1
Disclosed are compounds, compositions, and methods useful for imaging and treating tumor cells in a subject. In particular, the compounds have the structure of Formula I is useful in the dislocsed imaging methods : (I). The variables in ...  
WO/2024/026419A1
The present disclosure relates to compounds of Formula (I) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are usefu...  
WO/2024/026368A1
This disclosure is drawn to pyridine derivatives, compositions thereof, and associated methods, useful for inhibition of SARM1 activity and/or for treating or preventing neurological disorders.  
WO/2024/019597A1
The present invention provides: a novel heterocyclic compound, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating a disease related to autotaxi...  
WO/2024/020517A1
Provided herein are compounds of formula (II) and formula (I) that are inhibitors of QPCTL and QPCT: (II) & (I) Also provided are pharmaceutical compositions comprising the compounds, as well as the compounds for use in methods for the t...  
WO/2024/017876A1
The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions contai...  
WO/2024/020380A1
Substituted quinazoline compounds, conjugates, and pharmaceutical compositions for use in the treatment of cancer are disclosed herein. The disclosed compounds are useful, among other things, in the inhibition of CDK. In certain aspects,...  
WO/2024/019444A1
Provided is an organic compound contributing to improving the substantial light efficiency and field of view of an organic electroluminescent device. The organic electroluminescent device according to the present invention comprises: a f...  
WO/2024/017877A1
The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions contai...  

Matches 1 - 50 out of 30,545