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Matches 1 - 50 out of 28,938

Document Document Title
WO/2022/167695A1
The present invention relates to chromen-4-one derivatives, and to associated multi-salts, solvates, and pharmaceutical compositions. The present invention also relates to the use of such compounds and compositions in the treatment and p...  
WO/2022/167697A1
The present invention relates to chromen-4-one derivatives, and to associated multi-salts, solvates, prodrugs and pharmaceutical compositions. The present invention also relates to the use of such compounds and compositions in the treatm...  
WO/2022/169921A1
The present invention is directed to compounds of formula (I) and (II), wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said comp...  
WO/2022/166022A1
A purification method for Tedizolid phosphate. A crude product of Tedizolid phosphate is first mixed with absolute ethyl alcohol, impurities having a smaller polarity than the Tedizolid phosphate in the crude product of Tedizolid phospha...  
WO/2022/166721A1
The present invention relates to a series of fused ring derivatives containing 1,4-oxazepane and a preparation method therefor, and in particular relates to a compound as shown in formula (II) and a pharmaceutically acceptable salt thereof.  
WO/2022/167445A1
The present invention provides compounds of formula I, compositions thereof, and methods of using the same for the inhibition of GPR84, and the treatment of GPR84-mediated disorders.  
WO/2022/166917A1
A TYK2 inhibitor compound containing a bicyclic ring and the use thereof in the preparation of a drug for treating or preventing TYK2-related diseases.  
WO/2022/167819A1
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts, N-oxides, solvates and prodrugs thereof Formula (I) wherein R2, R3, R4, X1, X2, X3 and X4 are as defined in the specification, processes for t...  
WO/2022/166923A1
A phenyldihydropyrimidine compound as represented by formula I, a tautomer or a pharmaceutically acceptable salt thereof. The phenyldihydropyrimidine compound has a good anti-HBV activity and can be used for preparing drugs for treating ...  
WO/2022/169897A1
Provided herein are crystalline forms of a cyclin-dependent kinases (CDK) inhibitor, compositions thereof, methods of preparation thereof, and methods of use thereof.  
WO/2022/166938A1
The present invention relates to the field of herbicides, and in particular, to a uracil compound containing a carboxylate fragment and a preparation method therefor, a herbicidal composition, and a use. The uracil compound containing a ...  
WO/2022/169997A1
Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same. Representative lactam compounds include molecules falling within the following formulae:  
WO/2022/169755A1
The present application discloses novel compounds of formula (I), pharmaceutical compositions containing these compounds and methods of inducing degradation of a protein, comprising contacting the protein with an effective amount of a co...  
WO/2022/167330A1
The present invention relates to a crystalline form of (4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]tri azol-2-yl-benzyl)-morpholin-4-yl]-methanone, a process for the preparation thereof, pharmaceutical compositions comprisin...  
WO/2022/170164A1
The invention provides compounds and pharmaceutical compositions thereof, which are useful for inhibiting one or more mutations of EGFR, as well as methods for using such compounds to treat cancer associated with EGFR mutations.  
WO/2022/167699A1
The present invention relates to chromen-4-one derivatives, and to associated multi-salts, solvates, prodrugs and pharmaceutical compositions. The present invention also relates to the use of such compounds and compositions in the treatm...  
WO/2022/167457A1
The present invention provides compounds of formula (I), compositions thereof, and methods of using the same for the inhibition of GPR84, and the treatment of GPR84-mediated disorders.  
WO/2022/167698A1
The present invention relates to chromen-4-one derivatives, and to associated multi-salts, solvates, prodrugs and pharmaceutical compositions. The present invention also relates to the use of such compounds and compositions in the treatm...  
WO/2022/169184A1
The present invention relates to a novel compound and an organic light-emitting element comprising the novel compound in one or more organic layers to thus be highly efficient.  
WO/2022/164239A1
A novel pyrazole-carboxamide derivative compound provided as one example of the present invention exhibits an antagonist activity specific to cannabinoid receptor 1, and thus has a technical effect of effectively preventing or treating d...  
WO/2022/161274A1
Disclosed in the present invention are a pyrimidine-2,4-diamine compound, a preparation method therefor and the use thereof, relating to the technical field of pharmaceutical chemistry. The pyrimidine-2,4-diamine compound of the present ...  
WO/2022/160928A1
The present application belongs to the technical field of organic materials. Provided are a nitrogen-containing compound, and an electronic component and an electronic device containing same. The structural formula of the nitrogen-contai...  
WO/2022/161469A1
The present invention relates to an intermediate for a thiohydantoin drug, and a preparation method therefor and the use thereof. Specifically disclosed are a compound as represented by a formula (I) and multiple preparation methods ther...  
WO/2022/162210A1
The present invention covers compounds of general formula (I): [(C)n-L]-(V)m (I) where C is a chelator and n > 1, L is a multi-functional linker moiety comprising multiple functional groups for the covalent attachment of chelator such as...  
WO/2022/164019A1
The present invention relates to a reduction-reactive nitric oxide donor compound or prodrug capable of selectively releasing a nitric oxide under in vivo reducing conditions, and can be effectively used for preventing or treating cancer...  
WO/2022/165076A1
Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.  
WO/2022/160138A1
The present invention relates to a benzoxazine-4-one compound represented by formula (I) that acts as a glycogen phosphorylase inhibitor, a preparation method therefor, and a use thereof in a drug for the treatment and/or prevention of d...  
WO/2022/161462A1
A substituted morpholine derivative with a structure as shown in a formula (I). In addition, further disclosed are a pharmaceutically acceptable salt, a stereoisomer, a pharmaceutical composition and the use of the derivative.  
WO/2022/156788A1
Provided are a new compound for effectively inhibiting the activity of IRAK4, a preparation method therefor, and the use thereof in the preparation of a drug, wherein the new compound is a compound as represented by formula I, and a taut...  
WO/2022/156737A1
Disclosed are a crystal form of a compound (1S, 2S)-2-fluoro-N-(2-(2-(4-((R)-(5-methyl-2H-tetrazol-2-yl) (phenyl) methyl) piperidine-1-formyl) pyridin-4-yl) benzo [d] oxazol-5-yl) cyclopropyl-1-carboxamide having a structure of formula (...  
WO/2022/156708A1
Provided are a PARP7 enzyme inhibitor, a composition containing the inhibitor and the use thereof, synthetic methods for the preparation of PARP7 enzyme inhibitor and useful intermediates thereof.  
WO/2022/152821A1
Disclosed herein are compound or pharmaceutically acceptable salts or stereoisomers thereof of formula (I). These compounds find use as modulators of cereblon, in particular in the treatment of abnormal cell growth in mammals, especially...  
WO/2022/152852A1
This application relates to compounds of Formula (I), which are antagonists of MrgX2 (Mas-related Gene X2) and thus are useful as therapeutic agents, specifically therapeutic agents for use in the treatment of chronic spontaneous urticar...  
WO/2022/152853A1
This application relates to compounds of Formula I which are antagonists of MrgX2 (Mas-related Gene X2) and thus are useful as therapeutic agents, specifically therapeutic agents for use in the treatment of chronic spontaneous urticaria,...  
WO/2022/150574A1
Disclosed are compounds for inhibiting lipoamide dehydrogenase (Lpd), and methods of treating tuberculosis.  
WO/2022/147872A1
The present invention relates to a series of amide derivative neutral mitochondrial fluorescent markers, a preparation method therefor, and an application thereof; the present invention discloses for the first time that, after being link...  
WO/2022/148197A1
The present application relates to an organic compound, and an electronic element and electronic device using same. The organic compound has a structure as shown in Formula 1, in which A1 and A2 are independently selected from structures...  
WO/2022/150381A1
The present invention relates to novel substituted bicyclic derivatives that can inhibit Rho-kinases and/or Rho-kinase mediated phosphorylation of myosin light chain phosphates, compositions comprising the derivatives, methods for prepar...  
WO/2022/149925A1
The present invention relates to a novel oxadiazole phenylalanine derivative and a medical use thereof. A novel tryptophan hydroxylase inhibitor and a pharmaceutical composition, which contain same, inhibit the synthesis of serotonin in ...  
WO/2022/148196A1
A multikinase inhibitor and use thereof, a compound of formula I, and an isotope form, a stereoisomer form, a tautomer form, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a hydrate, a prodrug, and a polymorph...  
WO/2022/145408A1
The present invention provides compounds that have a serotonin 5-HT2A receptor antagonist and/or inverse agonist activity, and pharmaceutically acceptable salts thereof, and also provides a serotonin 5-HT2A receptor antagonist and/or inv...  
WO/2022/147210A1
Novel thiazole- and/or isoquinoline- containing compounds are presented that are useful for treating cancers as well as treating and/or preventing viral infections. Methods of treating and/or preventing broad-spectrum viral infections ar...  
WO/2022/147302A1
The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are usef...  
WO/2022/143773A1
Provided are a class of benzimidazole compounds and an application thereof as a 300/CBP inhibitor. Specifically, provided are a compound represented by formula (P) and a pharmaceutically acceptable salt thereof.  
WO/2022/135572A1
A compound represented by general formula (I) or a stereoisomer, tautomer, deuterated substance, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, an intermediate thereof, and a preparation method ther...  
WO/2022/135514A1
Provided are a class of multi-substituted uracil derivatives and a pharmaceutical composition containing such compounds, which compounds can be used as chymase inhibitors. Also provided are a method for preparing such compounds and the p...  
WO/2022/136366A1
The present invention relates to a novel method for producing NCA compounds. The invention also relates to a novel use of a peptide coupling agent. The method according to the invention enables NCA compounds to be obtained from α-amino ...  
WO/2022/135502A1
Provided are a multi-substituted uracil derivative represented by formula (I) and the use thereof. Specifically, the present invention relates to a class of novel multi-substituted uracil derivatives and a pharmaceutical composition cont...  
WO/2022/140326A1
The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided...  
WO/2022/140325A1
The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided...  

Matches 1 - 50 out of 28,938