Heterocyclic Compounds

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Document	Document Title
WO/2024/153217A1	INHIBITORS OF KIF18A AND USES THEREOF Described herein are KIF18A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with KIF18A.
WO/2024/153112A1	PDE4 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE The present disclosure relates to a PDE4 inhibitor, and a preparation method therefor and the use thereof in medicine. Specifically, the present disclosure relates to a compound as represented by general formula (I), a preparation method...
WO/2024/153246A1	SUBSTITUTED TRICYCLIC COMPOUND AND USE THEREOF Provided are a compound of formula (I) which acts as a Cbl-b inhibitor, or a stereoisomer thereof or a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition comprising the compound of formu...
WO/2024/153237A1	IGF-1R TYROSINE KINASE INHIBITORS, PHARMACEUTICAL COMPOSITION AND USE THEREOF The present disclosure relates to compounds represented by formula I, and pharmaceutically acceptable salts, isotope-labeled substances or isomers thereof, which are IGF-1R kinase inhibitors and can be used for treating diseases such as ...
WO/2024/155555A1	NEUROPROTECTIVE COMPOUNDS FOR THERAPEUTIC USE Provided are compounds that can reduce CD45+ CD4+ IFNy+ cells and inhibit or reduce inflammation. Also provided are methods of treating diseases characterized by inflammation using the compounds.
WO/2024/153173A1	AROMATIC ACETYLENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF The present invention relates to an aromatic acetylene derivative as represented by general formula (I), a preparation method therefor, a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, particularly ...
WO/2024/153225A1	NOVEL ALPK1 INHIBITORS The disclosure is directed to novel ALPK1 inhibitors having the Formula (I), or a pharmaceutical acceptable salt, a stereoisomer, a tautomer, a stable isotopic variant, a prodrug, or a crystal form thereof. The disclosure is also directe...
WO/2024/155021A1	COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT USING SAME, AND ELECTRONIC DEVICE THEREOF The present invention provides: a novel compound which can improve the luminous efficiency, stability, and lifespan of an element; an organic electric element using same; and an electronic device thereof.
WO/2024/153203A1	INTEGRASE INHIBITOR AND USE THEREOF Disclosed are a compound of Formula I, stereoisomers, pharmaceutically acceptable salts and deuterated compounds thereof and a method for treating, inhibiting and/or preventing a disease or disorder in a subject in need thereof: (I) wher...
WO/2024/153945A1	INHIBITORS OF MPTP The invention relates to compounds of formula (I), and related aspects.
WO/2024/153105A1	FIVE-MEMBERED HETEROCYCLIC COMPOUND, AND PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF Disclosed in the present invention are a five-membered heterocyclic compound and a pharmaceutical composition thereof and the use thereof. The structure of the five-membered heterocyclic compound is as shown in formula (I). A stereoisome...
WO/2024/153946A1	INHIBITORS OF MPTP The invention relates to compounds of formula (I), and related aspects.
WO/2024/153074A1	(TETRA-SUBSTITUTED-PHENYL)CYCLOHEXENYL THIOETHER COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF Disclosed in the present disclosure are (tetra-substituted-phenyl)cyclohexenyl thioether compounds and agriculturally acceptable salts thereof, and the use thereof as herbicides. The compounds are shown as general formula (I), each subst...
WO/2024/154683A1	PLANT DISEASE CONTROL COMPOSITION AND METHOD FOR CONTROLLING DISEASE OF USEFUL PLANT USING SAME The present invention provides a plant disease control composition capable of exhibiting an excellent control effect on plant diseases, and a method for controlling a disease of a useful plant using the composition. Provided are: a plant...
WO/2024/152986A1	HETEROARYL AMINO COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF The present invention relates to a heteroaryl amino compound, a preparation method therefor, and use thereof, as well as a compound represented by formula (I) or a pharmaceutically acceptable salt, a stereoisomer, a tautomer, a deuterate...
WO/2024/151833A1	SPIRO DERIVATIVES AS M4 ACTIVATORS/MODULATORS AND USES THEREOF The present disclosure provides compounds of Formula I: (l) (I), or an N- oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: A, Y, m, n,p, R1, R2, R3, R3a, R4, R5, R6, R7, and Z are as described...
WO/2024/151919A1	COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination and/or stereoisomers (e.g., enantiomers and diastereomers) of the compound) tha...
WO/2024/149231A1	PARP7 INHIBITORS AND USES THEREOF Described herein, inter alia, are PARP7 inhibitors and uses thereof.
WO/2024/149712A1	SELECTIVE ANGIOTENSIN II COMPOUNDS There is provided pharmaceutical compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, Y1, Y2, Y3, X and Z have meanings given in the description, which compounds are useful in the treatment of autoimmune and/or fibrotic diseases, in...
WO/2024/149728A1	SUBSTITUTED (HETERO)ANILINES AND THEIR USE The present disclosure relates to substituted anilines and heteroanilines and their use as TRPV4 antagonists. In some embodiments, the disclosure provides a compound of Formula (I): (I), or a pharmaceutically acceptable salt thereof, whe...
WO/2024/149189A1	AROMATIC AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF Provided are an aromatic amide derivative, a preparation method therefor, and a use of a pharmaceutical composition containing the derivative in medicine. Specifically, provided are an aromatic amide derivative as represented by general ...
WO/2024/150991A1	COMPOUND FOR ORGANIC ELECTRIC ELEMENT, ORGANIC ELECTRIC ELEMENT USING SAME, AND ELECTRONIC DEVICE THREREOF The present invention provides: a novel compound that can improve the luminescence efficiency, stability, and lifespan of an element; an organic electric element using same; and an electronic device thereof.
WO/2024/146923A1	TUBULIN POLYMERIZATION INHIBITORS The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, wherein B is an aryl or a five- or six-membered heteroaryl, and R1-R5, V, W, Y and Z may be various groups. The comp...
WO/2024/147306A1	AMIDE COMPOUND AND HARMFUL ARTHROPOD CONTROL COMPOSITION CONTAINING SAME The present invention provides a compound having excellent control efficacy against harmful arthropods. Provided is a compound represented by formula (I) (In the formula, R1 denotes a C1-C6 chain-like hydrocarbon group or the like; R2, R...
WO/2024/144220A1	ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME The present invention relates to a novel organic compound and an organic electroluminescent device using same and, more specifically, to an organic compound having excellent electron transport ability, heat resistance, carrier transport ...
WO/2024/143338A1	FIVE-MEMBERED HETEROARYL COMPOUND AND AGRICULTURAL AND HORTICULTURAL BACTERICIDE The present invention provides a compound represented by formula (I). (In the formula, the partial structure indicates a five-membered heteroaryl ring; Q1 indicates a phenyl group or the like; R4 indicates a hydrogen atom or the like; R5...
WO/2024/140653A1	SELECTIVE CDK12/13 INHIBITOR AND APPLICATION THEREOF The present invention belongs to the field of pharmaceutical chemistry, relates to a compound serving as a CDK12/13 inhibitor and to application of the compound, and specifically provides a compound shown in formula (I), or an isomer, ph...
WO/2024/145483A1	COMPOUNDS FOR USE IN THE TREATMENT OF CANCER AND METHODS OF MAKING AND USING THE SAME Disclosed herein are compounds that inhibit RNA modifying enzymes, such as METTL3, and thus can be used for treating and/or preventing diseases, such as cancers. Also disclosed herein are methods for making and using the disclosed compou...
WO/2024/140356A1	CATHEPSIN L INHIBITORS The present disclosure provides a plurality of the compounds. The compounds are capable of inhibiting Cathepsin L (CatL). A composition including at least one of these compounds is also provided. A method for treating or preventing one o...
WO/2024/140637A1	OXOISOINDOLINYL SUBSTITUTED PIPERIDINEDIONE DERIVATIVE AND USE THEREOF The present disclosure relates to a compound of formula (I) or a salt, enantiomer, stereoisomer, solvate or polymorph thereof, and a use thereof. The present disclosure further relates to a pharmaceutical composition comprising the compo...
WO/2024/140923A1	PRMT5-MTA INHIBITOR Provided in the present invention is a compound used as a PRMT5-MTA inhibitor, which is a compound represented by formula (I) or a pharmaceutically acceptable salt, isotopic variant, tautomer or stereoisomer thereof. Also provided in the...
WO/2024/144371A1	PHARMACEUTICALLY ACTIVE COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING PENDRIN The present invention relates to a novel compound as pendrin corrector represented by the following Chemical formula 1 and a composition for preventing or treating pendred syndrome and the related disease thereof comprising the same as a...
WO/2024/140319A1	PYRIMIDINE COMPOUND, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF The present invention relates to a pyrimidine compound, and a preparation method therefor and the medical use thereof. Specifically, the present invention relates to a compound as represented by general formula (I), a preparation method ...
WO/2024/140401A1	HETEROCYCLIC COMPOUND ACTING AS KINASE INHIBITOR, AND COMPOSITION COMPRISING SAME The present invention provides a compound represented by the following formula (I), and/or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof, and a preparation method thereof, a pharmaceutical compositi...
WO/2024/140799A1	INHIBITORS OF KIF18A AND USES THEREOF Described herein are KIF18A inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with KIF18A.
WO/2024/141004A1	COMPOUNDS AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND THE USE THEREOF Provided herein are novel compounds as inhibitors of macrophage migration inhibitory factor (MIF) pharmaceutical compositions comprising the compounds provided herein; as well as uses and methods for treating a disease mediated by MIF by...
WO/2024/144213A1	ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME The present invention relates to a novel organic compound and an organic electroluminescent device using same and, more specifically, to: an organic compound which has excellent electron transport ability, heat resistance, carrier transp...
WO/2024/140638A1	COMPOUND BASED ON SULFUR/OXYGEN SUBSTITUTED GLUTARIMIDE-BASED ISOINDOLINONE SKELETON AND USE THEREOF The present disclosure relates to the technical field of molecular glue degradation agents, and in particular to a compound of formula I based on a sulfur/oxygen substituted glutarimide-based isoindolinone skeleton and a use thereof. The...
WO/2024/145259A2	EP2 ANTAGONIST COMPOUNDS Disclosed herein are compounds that are EP2 antagonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of diseases or conditi...
WO/2024/141757A1	LSD1 MODULATORS Disclosed are compounds, compositions and methods for treating disease, syndromes, conditions and disorders that are affected by the modulation of LSD1. Such compounds are represented by formula (I) wherein the variables are defined herein.
WO/2024/134682A1	(N-ALKYLDIHYDROL-2H-OXAZINYL)-CANNABIDIOL AS ANTI-PROLIFERATIVE AGENT AND PROCESS FOR PREPARATION THEREOF The present invention relates to ring annulated analogues of cannabidiol where either one or both sides of the aromatic ring are attached to the oxazinyl ring, their method of preparation and use as anti-proliferative agents. The present...
WO/2024/132895A1	MICROBIOCIDAL DIHYDROOXADIAZINYL PYRIDAZINONE COMPOUNDS A compound of Formula (I) wherein the substituents are as defined in claim 1, useful as pesticides, especially as fungicides.
WO/2024/137981A1	NAMPT MODULATORS Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein Ring A, Ring B, L, RB, Rc, n, and p are as defined herein. Also provided are pharmaceutically acceptable compositions comprising a compound of ...
WO/2024/137426A1	PROCESS TO MAKE GLP1 RA AND INTERMEDIATES THEREFOR The present invention relates to the synthesis of 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fl uoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl )-2-oxoimidazol-1-yl]-4-methyl-6,7-dihydro-4H-pyrazolo[4,3-c ]pyr...
WO/2024/130344A1	TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 INHIBITORS The present invention relates to methods and uses of preventing or treating cancer The method or use may comprise administration of a cancer therapy together with a compound of Formula (I). In the compound of Formula (I) A is a substitut...
WO/2024/137674A2	CBL-B MODULATORS AND USES THEREOF The present invention provides compounds of formula I-III, compositions thereof, and methods of using the same for the inhibition of Cbl-b, and the treatment of Cbl-b-mediated disorders.
WO/2024/134498A1	SOLID STATE FORMS OF AFICAMTEN AND PROCESS FOR PREPARATION THEREOF The present disclosure encompasses solid state forms of Aficamten, in embodiments crystalline polymorphs of Aficamten, processes for preparation thereof, and pharmaceutical compositions thereof.
WO/2024/137358A1	KDM1A INHIBITORS FOR THE TREATMENT OF DISEASE Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differe...
WO/2024/133499A1	GLYCINE DERIVATIVES WITH P2X4 RECEPTOR-BLOCKING ACTIVITY AS DIAGNOSTICS AND FOR THE TREATMENT OF PAIN, INFLAMMATION, CANCER, AND OTHER P2X4 RECEPTOR-RELATED DISEASES The invention relates to glycine derivatives with P2X4 receptor-blocking activity for the treatment of pain, inflammation, cancer, and other P2X4 receptor-related diseases.
WO/2024/133426A1	METHOD FOR CONTROLLING DIAMIDE RESISTANT PESTS AND COMPOUNDS THEREFOR A method for combating and controlling diamide-resistant insects to (i) reduce damage on a plant, which comprises applying to the insect, to a locus of the insect, or to a plant susceptible to attack by the insect, an effective amount of...

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