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JP3277065B2 |
PURPOSE: To provide a novel compound which is useful in the synthesis of an optically active aldehyde to be used as a medicine, agrochemical, dye or their intermediate. CONSTITUTION: A compound of formula I (R4, R4' are respectively H, a...
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JP2002511470A |
[Chemical 1]
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JP2002114788A |
To provide a method for industrially advantageously producing an intermediate for producing a carbapenem derivative and to obtain the intermediate.This method comprises producing a compound of formula (5) (R2 is an amino group-protecting...
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JP2002509856A |
Compounds of formula (I) are disclosed as well as pharmaceutically acceptable salts thereof. The naphthosultam is substituted with various substituent groups including at least one cationic group -A-Q-L-B. The carbapenems of the inventio...
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JP2002088083A |
To provide a new carbapenem compound and a method for producing the same.This new carbapenem compound is a compound expressed by the formula (1) [wherein, R1 is H or methyl; R2 is H or a blocking group for hydroxy; R3 is H or a blocking ...
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JP2002047289A |
To provide an industrially advantageous method for producing an intermediate for a carbapenem derivative production and to obtain the intermediate.This method comprises producing a compound represented by formula (5) [R2 is an amino grou...
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JP2002503638A |
The present invention relates to carbapenem antibacterial agents of formula (I), as well as salts and hydrates thereof. Pharmaceutical compositions and methods of treatment are also included.
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JP2002029972A |
To provide an antimicrobial agent containing a carbapenem compound as the active ingredient, having excellent antimicrobial activity and oral absorbability.This antimicrobial agent is obtained by including a carbapenem ester compound hav...
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JP3252032B2 |
PURPOSE: To synthesize β-methylcarbapenem intermediates with high stereo- selectivity from easily available reagents. CONSTITUTION: A compound of formula I is brought to contact with a mild acid (e.g. acetic acid, formic acid) at 10 to ...
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JP3245427B2 |
A stabilized carbapenem intermediate compound represented by formula (1) or a salt thereof is disclosed, wherein P represents a carboxyl protecting group and X represents a charge balancing group. In addition, a process for synthesizing ...
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JP3242677B2 |
PURPOSE: To obtain a new β-lactam compound having excellent antimicrobial activity against imipenem-resistant Pseudomonas aeruginosa. CONSTITUTION: The objective compound of formula I {(j) is 0 or 1; R1 is H, OH-protecting group or form...
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JP3238512B2 |
PURPOSE: To obtain the subject compounds useful as an intermediate for producing a medicine, a medicine for animals or plants, a stereoisomeric alcohol, etc., under mild neutral conditions in a shortened process according to a new method...
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JP2001342134A |
To obtain an antimicrobial agent comprising a 1-methylcarbapenem compound capable of exhibiting an excellent antimicrobial activity as an active ingredient.This antimicrobial agent comprises the 1-methylcarbapenem compound having the gen...
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JP3233434B2 |
PURPOSE: To obtain a new compound, having a wide range of antimicrobial spectrum and useful as an antibiotic substance, etc., excellent in antimicrobial properties. CONSTITUTION: The objective compound of formula I [R1 is H or protected ...
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JP2001520229A |
Compounds of formula (I) are disclosed as well as pharmaceutically acceptable salts thereof. The naphthosultam is substituted with various substituent groups including at least one cationic group -A-Q-L-B. The carbapenems of the inventio...
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JP2001520192A |
The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least ...
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JP2001520191A |
Carbapenems substituted with a naphthosultam at position 2 and linked through a CH2 group are disclosed. Pharmaceutical compositions and methods of treatment are also included. The naphtosultam is substituted with at least one cationic g...
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JP2001519332A |
A process of synthesizing a carbapenem compound of formula (6), is disclosed using a compound of formula (4'). The intermediate compounds that are described herein are also included in the present invention.
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JP2001519352A |
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a -Z-CH2 group. The naphthosultam is further substituted with various s...
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JP2001519389A |
Compounds of formula (I), as well as pharmaceutically acceptable salts thereof are disclosed. R<2> is H and R<3> is C1-3 alkyl, or R<2> and R<3> taken in combination represent C1-3 alkylidene. Pharmaceutical compositions and methods of t...
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JP2001288186A |
To obtain a 1-methylcarbapenem compound having an excellent antimicrobial activity, its pharmacologically effective prodrug or its pharmacologically effective salt. This 1-methylcarbapenem compound has a general formula (1) [R1 is a 1-6C...
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JP2001280284A |
To prevent the occurrence of detective detection by improving detecting sensitivity in a way to decrease a gap between a sensor and a permanent magnet when the sensor to detect a change in the magnetic field of a permanent magnet 4 is di...
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JP2001515080A |
The present invention relates to carbapenem antibacterial agents of formula I:or a pharmaceutically acceptable salt thereof, wherein:R2 represents:in formula I, in which the carbapenem nucleus is substituted at the 2-position with a naph...
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JP2001220391A |
To provide a policyclic ccarbapenem compound expressed by formula Ia' or Ic', having excellent antibacterial activity and useful as an agent for the treatment of bacteriosis.The invention relates to a policyclic carbapenem compound expre...
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JP3199300B2 |
PURPOSE: To provide a new 1-methylcarbapenem derivative strong in antibacterial force, stable against dehydropeptidase I, and high in urinary recovery. CONSTITUTION: The objective compound of formula I {R1 is H, alkyl, alkenyl alkynyl, C...
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JP3175857B2 |
PURPOSE: To provide a compound useful as a synthetic intermediate for 1- substituted carbapenem derivative which is known as an excellent antibacterial agent. CONSTITUTION: The compound of formula I [R1 is H or OH-protecting group; R2 is...
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JP3176068B2 |
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a naphthosultam linked through a CH2 group. The naphthosultam is further substituted with various subs...
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JP3159984B2 |
The present invention provides a compound of formula (I) wherein: R<1> is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R<2> is hydrogen or C1-4alkyl; R<3> and R<4> are ortho with respect to one another wherein R<3> and R<4> are indepe...
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JP2001097987A |
To provide a storing method for an enol compound bearing an eliminable group, that can maintain the high quality of the fresh enol immediately after production, while it is transported and stored. An enol compound having an eleminable gr...
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JP3151215B2 |
A compound of the formula 1-cyclohexyloxycarbonyloxethyl (4S, 8S, 9R 10S, 12R)-4-methoxy-10-(1-hydroxyethyl)-11-oxo-1-azatricyclo[7.2.
0.0.3,8]undec-2-ene-2-carboxylate which is useful as a pharmaceutical composition to treat bacterial i...
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JP2001503765A |
A compound of formula (I), salts and metabolically labile esters thereof, wherein R represents optionally substituted aryl or heteroaryl group; A represents a propylene chain or A is a chain of 3 members one of which is selected from an ...
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JP3140058B2 |
A carbapenem compound of the formula (I) wherein: R<1> is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R<2> is hydrogen or C1-4alkyl; R<3> is hydrogen or C1-4alkyl; R<4> is hydroxy or carboxy; and the phenyl ring is optionally further...
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JP2001500862A |
The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a sulfonamide containing ring system linked to the carbapenem nucleus through a CH2 group. The compoun...
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JP3118143B2 |
PURPOSE: To sterically selectively obtain the subject compound useful as a synthetic intermediate for a 1β-methylcar bapenem derivative as an antimicrobial agent without using a Lewis acid by a new method using a specific alkanoic acid ...
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JP2000344773A |
To obtain a new compound having excellent antibacterial effect and absorbability through the digestive tract, and useful as a propylactic and/or therapeutic agent or the like for microbism.This compound is a compound of formula I (R1 is ...
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JP2000344774A |
To obtain the subject compound useful as an intermediate for industrially and economically producing carbapenem preparations for oral use, by treating a specific azetidinone compound with a specific oxalic acid monoester monochloride.Thi...
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JP2000344772A |
To obtain a new compound having excellent antibacterial effect and absorbability through the digestive tract, and useful as a prophylactic and/or therapeutic agent or the like for microbism.This compound is a compound of formula I (R1 is...
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JP2000264886A |
To obtain a stable new compound composed of a specific carbapenem ester compound, produced at a low cost, excellent in absorbability from the digestive canal, having low toxicity and useful as an antimicrobial agent for treating and prev...
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JP2000511925A |
(57) [Summary] The present invention relates to a compound of formula (I) and a salt thereof (where R).1, R2, R3, R4, And R5Provided a process of preparing (as defined herein; and none of the functional groups are optionally protected), ...
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JP2000239275A |
To obtain a new carbapenem ester derivative exhibiting pharmacokinetics with excellent absorbing property and persistency when administered to organisms and useful as an active ingredient for medicines for treating bacterial infectious d...
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JP2000229969A |
To obtain a new compound having excellent antibacterial activity, low in toxicity and useful as an antibacterial agent for treating bacterial infectious diseases. A compound of formula I (n is 2-4; R1 and R2 are each H or a 1-4C alkyl; R...
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JP2000191680A |
To obtain a new carbapenem derivative useful as, e.g., an intermediate for synthesizing a carbapenem compound having antibacterial activity. This new compound is expressed by formula I [wherein, R1 and R2 are each H or a (substituted) lo...
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JP2000191679A |
To obtain a new carbapenem derivative useful as, e.g., an intermediate for synthesizing a carbapenem compound having antibacterial activity. This new compound is expressed by formula I or II [wherein, R1 and R2 are each H or a (substitut...
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JP2000508343A |
A method is presented for stabilizing carbapenem antibiotics by carboxylating the pyrrolidinyl amino with a carbon dioxide source. The resulting compounds and pharmaceutical compositions thereof can be used in the treatment of infectious...
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JP3048646B2 |
A beta -methylcarbapenem compound of formula (I), a salt or an ester thereof, a process for the preparation thereof and a anti-bacterial composition containing same: (I) wherein: R1 is a C1-6 alkyl, C2-6 alkenyl, cycloalkyl, aryl or hete...
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JP3048196B2 |
PURPOSE: To provide the subject new compound useful as an antibiotic substance effective against various bacterial strains including Pseudomonas aeruginosa, having excellent safety and stable even to hydrolase such as DHP. CONSTITUTION: ...
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JP3046068B2 |
Antimicrobial quinolone thiourea compounds of the general formula: wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial ...
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JP2000143512A |
To prepare a metallo-β-lactamase inhibitor having inhibitor action against a β-lactamase belonging to the class B by including a specific compound as an active principle. This metallo-β-lactamase inhibitor is prepared by including a c...
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JP2000143511A |
To prepare a metallo-β-lactamase inhibitor having inhibitory action against a β-lactamase belonging to the class B by including a specific compound as an active principle. This metallo-β-lactamase inhibitor is prepared by including a ...
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JP2000136133A |
To obtain the subject inhibitor having inhibiting actions on metallo-β- lactamases by including a carbapenem compound as an active ingredient. This inhibitor is obtained by including a carbapenem compound represented by formula I [R1 is...
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