| Document |
Document Title |
|
WO/1995/014692A1 |
Carbapenem(3-pyrrolidinylthio-1-azabicyclo[3,2,0] hept-2-ene-7-one-carboxylic acid compounds and their derivatives. The compounds of the present invention are useful as antibacterial agents against gram positive, gram negative, imipenem-...
|
|
WO/1995/013278A1 |
Compounds of formula (I), salts and metabolically labile esters thereof; wherein R represents hydrogen or C1-6alkyl; R1 represents hydrogen or C1-6alkyl; R2 represents hydrogen or an optionally substituted alkyl, alkenyl, alkynyl, aryl, ...
|
|
WO/1995/011905A1 |
A compound of formula (I) in which R is (a), wherein R'alpha' is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; R'beta' is hydrogen, optionally substituted (C1-6)alkyl or optionally substituted aryl; or R'al...
|
|
WO/1995/010520A1 |
A compound of formula (I), in which R1 is carboxy, etc., R2 is hydroxy(lower)alkyl, etc., R3 is hydrogen or lower alkyl, R4 is 2(or 3)-methylpyridin-4-ylmethyl, etc., and R5 is hydrogen or imino-protective group, or pharmaceutically acce...
|
|
WO/1995/005380A1 |
Crystalline pivaloyloxymethyl (1R, 5S, 6S)-2-[(4R)-2-oxo-4-pyrrolidinylthio]-6-[(1R)-1-hydroxyethyl
]-1-methyl-1-carbapen-2-em-3-carboxylate represented by formula (I), crystalline pivaloyloxymethyl (1R, 5S, 6S)-2-[(4S)-2-oxo-4-pyrrolidi...
|
|
WO/1995/003700A1 |
Carbapenems of formula (I) are disclosed as useful antibacterial agents.
|
|
WO/1995/003699A1 |
Carbapenems of formula (I) are useful antibacterial agents. Compositions containing such compounds and methods of use are also disclosed.
|
|
WO/1994/028719A1 |
Carbapenems of formula (1) are useful antibacterial agents.
|
|
WO/1994/029313A1 |
A novel beta-lactam compound represented by general formula [1] and having an excellent antibacterial activity against gram-positive bacteria, in particular, methicillin-resistant staphylococci and methicillin-resistant coagulase-negativ...
|
|
WO/1994/028718A1 |
Carbapenems of formula (I) are useful antibacterial agents. Compositions containing such compounds and methods of use are also disclosed.
|
|
WO/1994/025442A1 |
The invention concerns 3-(Hetero)aryl carboxylic acid derivatives of formula (I) in which R is a formyl group, a CO2H group or a group which can be hydrolysed to give a COOH group and the other substituents are as follows: R2 and R3 are ...
|
|
WO/1994/023577A1 |
Triazolyl and tetrazolyl phenyl substituted carbapenems of formula (I) are disclosed. One or two of the variables X, Y and Z represent nitrogen atoms. The heteroaryl ring may be charged or uncharged. Pharmaceutical compositions and metho...
|
|
WO/1994/021637A1 |
A process for the preparation of the antibacterial compound of formula (I) or a salt thereof which comprises the thermal cyclisation of a compound of formula (II), wherein R is a carboxyl protecting group, followed by removal of the said...
|
|
WO/1994/021638A1 |
A process for the preparation of antibacterial compound (I) or a salt thereof which comprises hydrogenolysis of the novel compound of formula (II) and if necessary or desired isolating the resultant carboxylic acid as a salt thereof.
|
|
WO/1994/017065A1 |
The present invention relates to antibacterial agents of the carbapenem class, in which the 2-position sidechain is characterized by a phenanthridine moiety, substituted by various neutral substituents.
|
|
WO/1994/017066A1 |
The present invention relates to antibacterial agents of the carbapenem class, in which the 2-position sidechain is characterized by a phenanthridine moiety typically having a substituent attached to the nitrogen of the phenanthridine an...
|
|
WO/1994/014811A1 |
The present invention relates to novel 2-(2-substituted pyrrolidin-4-yl)-thio-carbapenem derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which R1 represents hydrogen or (lower)alkyl, R2 represents hydrogen o...
|
|
WO/1994/011372A1 |
The present invention is directed to a process of making 2-aryl carbapenems of formula (1) from a compound of formula (2).
|
|
WO/1994/009002A1 |
Carbapenems of formula (I), wherein a suitably substituted aza-9-fluorenone is attached at the 2-position of the carbapenem are useful antibacterial agents.
|
|
WO/1994/006764A1 |
The present invention is directed to a process of, and intermediates for, making a Beta-methyl carbapenem intermediate of formula (VI) from a compound of formula (I), wherein R and P' are protecting groups and Nu is a nucleophilic group.
|
|
WO/1994/005666A1 |
The present invention relates to compounds of formula (I) and salts and metabolically labile esters thereof; wherein R is a 5 or 6 membered nitrogen containing heteroaryl group, which heteroaryl group optionally contains 1 or 2 additiona...
|
|
WO/1994/005669A1 |
Carbapenems of formula (I) are useful antibacterial agents.
|
|
WO/1994/005667A1 |
The present invention relates to a compound of formula (I) wherein R1 is selected from the group consisting of a hydrogen atom or a methyl group, R2 is selected from the group consisting of a hydrogen atom, a metal or a nonmetal salt gro...
|
|
WO/1993/023402A1 |
A compound of formula (I) in which R1 is carboxy, COO- or protected carboxy, R2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R3 is hydrogen or lower alkyl, and R4 is substituted lower alkyl or substituted lower alkenyl and R5...
|
|
WO/1993/021186A1 |
A compound of formula (I), in which R?1¿ is carboxy or protected carboxy, R?2¿ is 1-hydroxyethyl, R?3¿ is methyl, R?4¿ is optionally substituted pyridyl(lower)alkyl, optionally N-substituted 2-oxopiperazin-1-yl-(lower)alkyl, optional...
|
|
WO/1993/019072A1 |
A carbapenem derivative represented by general formula (I) or a salt thereof. It has an excellent antibacterial activity against a wide variety of gram-positive and negative bacteria, thus being useful as an antibacterial agent.
|
|
WO/1993/019070A1 |
The present invention relates to carbapenems and provides a compound of formula (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; and the thienyl ring is optional...
|
|
WO/1993/016080A1 |
A carbapenem derivative represented by general formula (I) or a salt thereof, wherein (a) represents (un)substituted pyridinium, (b), (c), (d) or (e); R1 and R2 may be the same or different from each other and each represents lower alkyl...
|
|
WO/1993/015078A1 |
The present invention relates to carbapenems and provides a compound of formula (I) or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen...
|
|
WO/1993/011128A1 |
A compound of formula (I), wherein R?1¿ is a hydrogen atom or a methyl group, R?2¿ is a hydrogen atom or a negative charge, R?3¿ is a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkoxy group, a lower alkanoyloxy group, an...
|
|
WO/1993/007154A1 |
The present invention provides methods of making compounds of the structure [Q - L1] - L - [L2 - B], wherein Q is a quinolone moiety; B is a beta-lactam moiety; L, L1, and L2 together comprise a carbamate-containing linking moiety, compr...
|
|
WO/1993/006102A1 |
A compound represented by general formula (I), pharmaceutically acceptable salt and ester thereof, production thereof, and the use thereof as an antibacterial agent. In formula (I), R represents hydrogen or methyl; R1 represents hydrogen...
|
|
WO/1993/001192A1 |
A compound of formula (I), wherein R?1¿ is a hydrogen atom or a methyl group, R?2¿ is a hydrogen atom or a negative charge, R?3¿ is a hydrogen atom or lower alkyl group, each of R?4¿, R?5¿ and R?6¿ is a hydrogen atom, a cyano group...
|
|
WO/1993/000344A1 |
Known carbapenem derivatives such as thienamycin have disadvantages that they are physicochemically unstable and readily decomposed by enzymes such as DHP of the kidney to bring about adverse effects such as nephrotoxicity, while 1-$g(b)...
|
|
WO/1992/017480A1 |
The present invention provides a compound of formula (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; n is zero or an integer 1 to 4; and P is a benzene ring substituted by groups R3 and R4...
|
|
WO/1992/017479A1 |
The present invention provides a compound of formula (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 and R4 are ortho with respect to one another wherein R3 and R4 are independently hydr...
|
|
WO/1992/017481A1 |
A carbapenem compound of formula (I) wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4alkyl; R3 is hydrogen or C1-4alkyl; R4 is hydroxy or carboxy; and the phenyl ring is optionally further substituted...
|
|
WO/1992/015587A1 |
Compounds of formula (I) in which R1 represents a hydrogen atom or a hydroxyl protecting group; R2 represents a hydrogen atom, a carboxyl protecting group or a cation derived from an inorganic base or an organic base; R3 represents the g...
|
|
WO/1992/015588A1 |
Compounds of formula (I) in which R1 represents the group (a) wherein R4 represents a hydrogen atom or a C1-4 alkyl group; p is zero or one, and R5 represents a group selected from C1-6 alkyl, C5-8 cycloalkyl optionally substituted by a ...
|
|
WO/1992/015586A1 |
Compounds of general formula (I) in which R1 represents a hydrogen atom or a hydroxyl protecting group, R2 represents a hydrogen atom or a carboxyl protecting group, and R3 represents the group N(R4)-CH=NR5 wherein R4 represents a hydrog...
|
|
WO/1992/010502A1 |
Heterocyclic carboxylic esters or derivatives thereof, comprising a beta-lactam moiety linked by a carboxylic acid bridge to an imidazole moiety for use as antimicrobial agents are provided. Also methods for the preparation of these este...
|
|
WO/1992/009605A1 |
A carbapenem derivative having an R-configuration at the 5-position, represented by general formula (I), and optically active pyrrolidine derivatives represented by general formulae (XI) and (XII), all of these compounds serving as the i...
|
|
WO/1992/006978A1 |
1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds of formula (a), in which R1 is carboxy, COO- or protected carboxy, R2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R8 is hydrogen or lower alkyl, Z is a group of formu...
|
|
WO/1992/003437A1 |
Compounds of general formula (I) in which R¿1? represents the group (a), where R¿4? represents a hydrogen atom or a C¿1-4? alkyl group; p is 0 or 1; R¿5? is a group selected from C¿1-6? alkyl, C¿5-8? cycloalkyl optionally substitut...
|
|
WO/1992/002521A1 |
A compound of formula (I) in which R?1¿ is carboxy, protected carboxy or carboxylato, R?2¿ is hydroxy(lower)alkyl or protected hydroxy-(lower)alkyl, R?3¿ is axetidinyl, pyrrolidinyl, imidazolinyl, tetrahydropyrimidinyl, piperidyl, 1,1...
|
|
WO/1991/016310A1 |
Antimicrobial quinolone thiourea compounds of general formula (I), wherein (1) A1, A2, A3, R1, R3, R4, and R6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial ...
|
|
WO/1991/016327A1 |
Antimicrobial quinolonyl lactam compounds comprising a lactam-containing moiety linked to a quinolone moiety, of formula (I), wherein (1) A1, A2, A3, R1, and R4 generally form any of a variety of quinolone, naphthyridine or related cycli...
|
|
WO/1991/014687A1 |
A compound of formula (I) wherein R is a hydrogen atom or a methyl group, R?1� is a hydrogen atom or a negative charge, each of R?2� and R?3� which may be the same or different, is a hydrogen atom, a lower alkyl group, a formimidoy...
|
|
WO/1991/009860A1 |
A compound of general formula (I), pharmaceutically acceptable salts and esters thereof, process for the production thereof, and antibacterial agents containing the same as the active ingredient, wherein R represents hydrogen or methyl; ...
|
|
WO/1991/000864A1 |
Compounds represented by general formula (I), pharmaceutically acceptable salts and esters thereof, and preparation and uses thereof, wherein R1 represents hydrogen or methyl; R2 represents hydrogen, cyano, carboxyl, lower alkoxycarbonyl...
|
