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Matches 1 - 50 out of 31,251

Document Document Title
WO/2022/166796A1
Disclosed are a novel pyrimidine/pyridine and heterocyclic adenosine receptor inhibitor, a preparation method therefor and use thereof. The novel pyrimidine/pyridine and heterocyclic adenosine receptor inhibitor is a compound as represen...  
WO/2022/166468A1
A heterocyclic compound that acts as a BTK inhibitor, a preparation method therefor, and an application thereof in medicine. Specifically, the present invention relates to a compound represented by general formula (I) and a pharmaceutica...  
WO/2022/166817A1
Disclosed are a heterocyclic compound, and an intermediate thereof, a preparation method therefor and the use thereof. Namely, provided are a heterocyclic compound as shown in formula I-a, and a tautomer and a pharmaceutically acceptable...  
WO/2022/168115A1
The present invention provides a process for the preparation of Larotrectinib or its pharmaceutically acceptable salts with a key intermediate of Formula IV by using Formula IIa.  
WO/2022/166866A1
A class of macrocyclic compounds containing a dihydropyrazine and pyrazine structure, and, in particular, disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.  
WO/2022/169798A2
The present disclosure relates to novel compounds that degrade Bruton's tyrosine kinase (BTK), pharmaceutical compositions containing such compounds, and their use in prevention and treatment of conditions modulated by BTK.  
WO/2022/167438A1
The present invention relates to a compound of formula (I) wherein R1 represents H, (C1-C6)alkyl-; hydroxy-(C1-C6)alkyl-; NH2-(C1-C6)alkyl-; NH-(C1-C6)alkyl-(C1-C6)alkyl-; N((C1-C6)alkyl)2-(C1-C6)alkyl-; (C2-C6)alkenyl-; (C2-C6)alkynyl-;...  
WO/2022/169921A1
The present invention is directed to compounds of formula (I) and (II), wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said comp...  
WO/2022/166920A1
The present invention relates to a pyrrolopyridazine compound as represented by a formula (I) or a pharmaceutically acceptable salt thereof, and also relates to a pharmaceutical preparation, a pharmaceutical composition and the use there...  
WO/2022/166970A1
Provided in the present invention are a proteolysis targeting chimera, and a preparation method therefor and a pharmaceutical composition and the use thereof. Specifically, the proteolysis targeting chimera comprises the following struct...  
WO/2022/166799A1
Provided are a fused tricyclic cyclin-dependent kinase inhibitor, and a preparation method therefor and a pharmaceutical use thereof. In particular, the structure of the fused tricyclic cyclin-dependent kinase inhibitor is shown in formu...  
WO/2022/166778A1
A pharmaceutical composition of a capsid protein inhibitor and a preparation method thereof. Specifically, provided is a composition, comprising (S)-N5-(3,4-difluorophenyl)-6-methyl-N3-((R)-1,1,1-trifluoro propan-2-yl)-6,7-dihydro-[1,2,3...  
WO/2022/166610A1
Provided are a pyridazinone heterocyclic compound, a preparation method therefor and the use thereof. Specifically, provided are a compound, as represented by formula I, or a pharmaceutically acceptable salt, stereoisomer, tautomer, poly...  
WO/2022/169758A1
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt thereof, or an N-oxide thereof), which are positive allosteric modulators of one or more GABA-A receptors, e.g., which are peripherally re...  
WO/2022/166844A1
Tricyclic compounds of formula (I), pharmaceutical compositions comprising same, methods for preparing same, and uses thereof, wherein each variable is as defined in the description.  
WO/2022/169974A1
The present invention relates to pharmaceutical compounds, compositions, combinations, and methods, especially as they are related to compositions and methods for the treatment and/or prevention of conditions such as gout that are associ...  
WO/2022/167866A1
The present disclosure relates in part to chemical modulators of protein phosphatase 2A (PP2A), comprising formula (I). The compounds of the present disclosure are useful in treating, preventing, and/or ameliorating cancer, diabetes, aut...  
WO/2022/166923A1
A phenyldihydropyrimidine compound as represented by formula I, a tautomer or a pharmaceutically acceptable salt thereof. The phenyldihydropyrimidine compound has a good anti-HBV activity and can be used for preparing drugs for treating ...  
WO/2022/166469A1
A heterocyclic compound as a fibroblast growth factor receptor (FGFR) inhibitor, a preparation method therefor, and the pharmaceutical use thereof. In particular, the present invention relates to a compound represented by general formula...  
WO/2022/170200A1
The present invention refers to l-(2-sulfonyl-2,6-dihydropyrrolo[3,4- c]pyrazol-5(4H)-yl]-ethanone derivatives of formula (I) as pyruvate kinase (PKR) and/or PKM2 activators for use in the treatment of sickle cell disease, sickle cell an...  
WO/2022/168956A1
This compound represented by the following general formula has excellent light emitting properties. Ar1 represents a benzene ring, a naphthalene ring, a phenanthrene ring, or the like, D represents a 5H-indolo[3,2,1-de]phenazin-5-yl grou...  
WO/2022/166860A1
A compound having a structure as shown in general formula (I), a deuterated compound, a stereoisomer, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising same, and use thereof. The compound has a good P...  
WO/2022/165598A1
The present technology relates to an ionic plastic crystal comprising at least one delocalized anion paired with at least one cation derived from a guanidine, amidine or phosphazene organic superbase for use in electrochemical applicatio...  
WO/2022/169997A1
Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same. Representative lactam compounds include molecules falling within the following formulae:  
WO/2022/166548A1
Provided are a salt form and a crystal form of a pyrazole substituted imidazo[1,2-a]quinoxaline derivative, and a preparation method therefor. Specifically disclosed are a salt form and a crystal form of a compound of formula (I), and a ...  
WO/2022/169864A1
The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted pyrrolo[2,3-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.  
WO/2022/169755A1
The present application discloses novel compounds of formula (I), pharmaceutical compositions containing these compounds and methods of inducing degradation of a protein, comprising contacting the protein with an effective amount of a co...  
WO/2022/167682A1
The present invention relates to new compounds capable of inhibiting the activity of SHP2 phosphatase, having the general Formula (I).  
WO/2022/106469A3
The present invention provides compounds of formula (I), for the treatment of an infection in warm-blooded animal caused by endoparasites, more preferably a helminthic infection, even more preferably a heartworm infection. Exemplary comp...  
WO/2022/167867A1
The present disclosure relates in part to chemical modulators of protein phosphatase 2A (PP2A). The compounds of the present disclosure are useful in treating, preventing, and/or ameliorating cancer, diabetes, autoimmune disease, solid o...  
WO/2022/167627A1
The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds accord...  
WO/2022/106902A3
Provided herein are benzenesulfonamide compounds, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.  
WO/2022/166741A1
A macrocyclic compound containing a benzoheterocycle and acting as an EGFR kinase inhibitor. Specifically disclosed is a compound as represented by formula I or a pharmaceutically acceptable salt, a stereoisomer and a tautomer thereof, a...  
WO/2022/167457A1
The present invention provides compounds of formula (I), compositions thereof, and methods of using the same for the inhibition of GPR84, and the treatment of GPR84-mediated disorders.  
WO/2022/165114A1
The present invention relates to compounds which are inhibitors of CD38 and are useful in the treatment of cancer.  
WO/2022/164735A1
The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fi...  
WO/2022/061155A9
Compounds having activity as anti-cancer agents are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salt, stereoisomer or tautomer, thereof, wherein X, Y, R1, R2, R3 R4, R5 and L are as defined h...  
WO/2022/161448A1
The application describes dihydropyrimidine derivatives which are useful in the treatment or prevention of HBV infection or of HBV-induced diseases, more particularly of HBV chronic infection or of diseases induced by HBV chronic infecti...  
WO/2022/160661A1
The present application provides a nitrogen-containing compound and an electronic component comprising same, and an electronic apparatus, and relates to the technical field of organic electroluminescence. The nitrogen-containing compound...  
WO/2022/164934A1
The present disclosure provides methods, compounds and compositions that are relevant to DNA-repair and DNA-repair proteins such as tyrosyl-DNA phosphodiesterase 1 (TDP1) and type I topoisomerase (TOP1).  
WO/2022/160015A1
The present invention relates to a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and to pharmaceutical compositions comprising the compound. In Formula (I), rings W, X, Y and Z may relate to various heterocyclic...  
WO/2022/164789A1
The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and ph...  
WO/2022/162034A1
The present invention provides compounds of formula I or II: (I) wherein X1, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the ...  
WO/2022/163377A1
Provided is a photosensitizer which has a specific structure, and has higher sensitivity than existing photosensitizers when light irradiation causes a rapid change from hydrophilicity to hydrophobicity. The present invention pertains to...  
WO/2022/161507A1
Provided are a crystal form of Brepocitinib tosylate, and a preparation method, pharmaceutical composition, and use therefor.  
WO/2022/164085A1
Provided are a pharmaceutical composition and a method that each use a maleate of a triazolopyrazine derivative. In an aspect, the pharmaceutical composition provided by the present invention exhibits improved storage stability and pharm...  
WO/2022/165076A1
Provided herein are GLP-1 receptor modulator compounds, pharmaceutical compositions, methods of their preparation, and methods of their use in treatment, and/or diagnosis.  
WO/2022/161462A1
A substituted morpholine derivative with a structure as shown in a formula (I). In addition, further disclosed are a pharmaceutically acceptable salt, a stereoisomer, a pharmaceutical composition and the use of the derivative.  
WO/2022/161461A1
The present invention provides a series of compounds of an SOS1 inhibitor. Specifically disclosed are a compound of formula (I), a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound and the sal...  
WO/2022/163846A1
The purpose of the present invention is to provide: a novel stereoselective method for producing a cyclic dinucleotide derivative that can be used for an antibody-immunostimulator conjugate; and a production intermediate thereof. Another...  

Matches 1 - 50 out of 31,251