Heterocyclic Compounds

Matches 851 - 900 out of 8,163	< 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 >

Document	Document Title
WO/2017/155030A1	COMPOUND, AND ORGANIC SEMICONDUCTOR MATERIAL INCLUDING SAME Provided is a tetrazolopyridine compound that is useful as an organic semiconductor material. This compound is characterized by being represented by any of formulas (1)-(3). [In formulas (1)-(3), Y1 and Y2 each independently represent a ...
WO/2017/150477A1	CRYSTAL OF COMPOUND HAVING JAK-INHIBITING ACTIVITY The purpose of the present invention is to provide a compound having an excellent JAK1-inhibiting activity. The compound according to the present invention has a JAK1-inhibiting activity, and therefore has an immunesuppressing effect, an...
WO/2017/144633A1	GLYCOSIDASE INHIBITORS Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
WO/2017/144639A1	GLYCOSIDASE INHIBITORS Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
WO/2017/147312A1	COMBINATION THERAPIES FOR TREATMENT OF SPINAL MUSCULAR ATROPHY Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.
WO/2017/144341A1	CONDENSED BICYCLIC HETEROCYCLE DERIVATIVES AS PEST CONTROL AGENTS The invention relates to novel compounds of formula (I), in which Aa, Ab, Ac, Ad, R1, R2, R3, Q and n have the meanings indicated in the description, to the use thereof as acaricides and/or insecticides for controlling animal pests, and ...
WO/2017/147410A1	COMPOUNDS THAT INHIBIT MCL-1 PROTEIN Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharma...
WO/2017/144637A1	ACID ADDITION SALTS OF PIPERAZINE DERIVATIVES The invention relates to acid addition salts of piperazine derivatives, as well as solid forms, such as polymorphic forms, thereof, which are useful as pharmaceutical ingredients and in particular as glycosidase inhibitors.
WO/2017/146220A1	QUINOLINE COMPOUND HAVING FUSED HETEROCYCLE LINKED THERETO, N-OXIDE OR SALTS THEREOF, AND AGRICULTURAL AND HORTICULTURAL INSECTICIDE CONTAINING COMPOUND, AND METHOD OF USING SAME The present invention addresses the problem of developing and providing a novel agricultural and horticultural insecticide because of factors such as existing devastation to crop production in agriculture, horticulture, etc., caused by i...
WO/2017/142324A2	MULTISUBSTITUTED 4H-THIAZOLO[4,5-E][1,4]DIAZEPINE-5,8-DIONE DERIVATIVE AND USE THEREOF The present invention relates to a multisubstituted 4H-thiazolo[4,5-e][1,4]diazepine-5,8-dione derivative represented by chemical formula 1 and a use of the derivative, which is useful for a vascular inflammation-related infectious disea...
WO/2017/139209A1	C5-C6-OXACYLIC FUSED IMINOTHIAZINE DIOXIDE COMPOUNDS BEARING AN ETHER LINKER AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE In its many embodiments, the present invention provides certain C5-C6-oxacyclic fused iminothiazine dioxide compounds bearing an ether linker, including compounds Formula (I) or a tautomer thereof, and pharmaceutically acceptable salts o...
WO/2017/139210A1	C5-C6-OXACYLIC FUSED IMINOTHIADIAZINE DIOXIDE COMPOUNDS BEARING AN ETHER LINKER AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE In its many embodiments, the present invention provides certain C5-C6-oxacyclic fused iminothiadiazine dioxide compounds bearing an ether linker, including compounds Formula (I): or a tautomer thereof, and pharmaceutically acceptable sal...
WO/2017/133655A1	BENZOTHIAZINE AND BENZOTHIADIAZINE COMPOUNDS AND PREPARATION AND USE Provided are benzothiazine and benzothiadiazine and a structural analogue thereof, as well as a pharmaceutically acceptable salt, a stereoisomer and a solvate thereof, having the structure of general formula a. It has been confirmed by m...
WO/2017/127627A1	COMPOUNDS FOR TREATMENT OF TRYPANOSOMES AND NEUROLOGICAL PATHOGENS AND USES THEREOF The present invention relates to novel compounds that cross the blood-brain barrier and are effective inhibitors of neurological pathogens such as trypanosomes. The invention further relates to the use of these compounds for treating dis...
WO/2017/122209A2	NF-kappaB INHIBITORS Disclosed herein are compounds capable of inhibiting dimerization of NF-κB, for example, p65-p65 homodimerization and/or p50-p65 heterodimerization, the compounds being represented by formula I: X-L2-L1-L'2-Y Formula I wherein X, Y, L1,...
WO/2017/123860A1	SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This inve...
WO/2017/118262A1	ORGANIC COMPOUND AND USE THEREOF Disclosed are an organic compound and a use thereof. The organic compound has a general formula (1) as follows: wherein, -X- and -Y- respectively independently represent -O-, -S-, -S＝O-, -SO2-, -N(R100)-, -C(R200)(R201)- or -Si(R300)(R...
WO/2017/114249A1	USES OF COMPOUND IN PREPARATION OF DRUGS FOR TREATING BRAIN GLIOMA The present invention provides uses of a compound represented by formula A in the preparation of drugs for treating brain glioma and particularly glioblastoma. Particularly provided are uses of the compound represented by formula A in th...
WO/2017/109025A1	HETEROCYCLIC COMPOUNDS AND THEIR USE IN PREVENTING OR TREATING BACTERIAL INFECTIONS The present invention relates to heterocyclic compounds, their process of preparation, pharmaceutical compositions comprising these compounds and use thereof, optionally in combination with other antibacterial agents and/or beta-lactam c...
WO/2017/109724A1	HETEROCYCLIC AMIDES AS KINASE INHIBITORS Disclosed are compounds having the formula (I) wherein Q, X, A, L, B, Q4, R, RA, R5, n and m are as defined herein, and methods of making and using the same.
WO/2017/112768A1	INHIBITORS OF THE MENIN-MLL INTERACTION The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the me...
WO/2017/109855A1	THIAZOLE COMPOUND, AND AGRICULTURAL AND HORTICULTURAL GERMICIDE INCLUDING SAME The present invention pertains to: a compound represented by formula [1] or a salt thereof; a germicidal composition including the compound or a salt thereof; a method for controlling plant disease caused by a phytopathogenic microorgani...
WO/2017/106288A1	NOVEL COMPOUNDS AND METHODS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND/OR CEREBRAL AMYLOID ANGIOPATHY Described herein are novel compounds and methods for the treatment and/or prevention of cerebral amyloidoses such as Alzheimer's disease (AD) and/or cerebral amyloid angiopathy (CAA).
WO/2017/105040A1	ORGANIC ELECTROLUMINESCENT COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME The present disclosure relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. The organic electroluminescent compound of the present disclosure can provide an organic electrolumine...
WO/2017/105382A1	CRYSTALLINE FORMS OF QUINOLONE ANALOGS AND THEIR SALTS The present invention includes crystalline forms of 2-(4-Methyl-[1,4]diazepan-1-yl)-5-oxo-5H-7-thia-1,11b-diaza- benzo[c]fluorene-6-carboxylic acid (5-methyl-pyrazin-2-ylmethyl)-amide and crystalline forms of salts and/or solvates of 2-(...
WO/2017/100925A1	METAL COMPLEXED THERAPEUTIC AGENTS AND LIPID-BASED NANOPARTICULATE FORMULATIONS THEREOF Provided herein is a pharmaceutical formulation for delivery of a therapeutic agent having a metal complexation moiety and a solubility in water or a metal ion solution of less than 1 mg/ml. Said formulation comprises the therapeutic age...
WO/2017/100591A1	HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compou...
WO/2017/093718A1	1-CYANO-PYRROLIDINE DERIVATIVES AS INHIBITORS OF USP30. The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylatingenzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C- terminal hydrolase 30 or Ubiquitin S...
WO/2017/088746A1	NEW EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR AND APPLICATION THEREOF An epidermal growth factor receptor inhibitor as shown in the following formula, a pharmaceutical composition containing the receptor inhibitor, and use of the inhibitor or the pharmaceutical composition as a medicine for preventing and/...
WO/2017/085484A1	FUSED THIAZOLOPYRIMIDINE DERIVATIVES AS MNKS INHIBITORS The present invention relates to compounds of formulae I and H, or pharmaceutically acceptable salts or esters thereof. Further aspects of the invention relate to pharmaceutical compositions and therapeutic uses of said compounds in the ...
WO/2017/086729A1	ORGANIC ELECTROLUMINESCENT COMPOUND, ORGANIC ELECTROLUMINESCENT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME The present disclosure relates to an organic electroluminescent compound, an organic electroluminescent material, and an organic electroluminescent device comprising the same. By using the organic electroluminescent compound of the prese...
WO/2017/077008A1	SELECTIVE HDAC8 INHIBITORS AND THEIR USES The present invention relates to small molecule compounds based on benzopyrimido- or benzoimidazo-thiazin-imine as well as their (synthesis) intermediates and their use as HDAC inhibitors, in particular HDAC8 inhibitors. The present inve...
WO/2017/073942A1	ELECTRON BUFFERING MATERIALS, ELECTRON TRANSPORT MATERIALS AND ORGANIC ELECTROLUMINESCENT DEVICE COMPRISING THE SAME The present disclosure relates to an electron buffering material, and an organic electroluminescent device comprising a first electrode, a second electrode facing the first electrode, a light-emitting layer between the first electrode an...
WO/2017/069279A1	HETEROCYCLIC COMPOUND Provided is a compound that has an effect of inhibiting RIP1 kinase and is useful as a prophylactic or therapeutic agent for Gaucher's disease, Niemann-Pick disease, inflammatory bowel disease, multiples sclerosis, chronic nephropathy, a...
WO/2017/069275A1	NOVEL BICYCLIC HETEROCYCLIC COMPOUND The present invention provides a novel compound having excellent inhibitory action against KAT II, a production method therefor, a use therefor, and a pharmaceutical composition, or the like, that includes the compound. Provided is the c...
WO/2017/066863A1	HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PLATELET AGGREGATION The present invention provides compounds of Formula I: wherein Y, AA, W, R3, R2, R4, R5, R6, R7, X1, X2, X3, X4 and X5 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug or esters or solvate for...
WO/2017/062729A1	HETEROCYCLE-SUBSTITUTED BICYCLIC AZOLE PESTICIDES Disclosed are compounds of Formula (1), including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q is and A, R1, m, X1, X2, Y1, Y2, Y3 and R5a are as defined in the disclosure. Also disclosed are compositions conta...
WO/2017/060406A1	QUINOXALINE AND PYRIDOPYRAZINE DERIVATIVES AS PI3KBETA INHIBITORS The present invention relates to substituted quinoxaline and pyridopyrazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3Kβ in...
WO/2017/051276A1	N-[2-(2-AMINO-6,6-DISUBSTITUTED-4, 4A, 5, 6-TETRAHYDROPYRANO [3,4-D][1,3] THIAZIN-8A (8H)-YL) -1, 3-THIAZOL-4-YL] AMIDES The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula (I), and the variables R1, R2 and R3 are as defined...
WO/2017/046117A1	SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE Compounds of formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modu...
WO/2017/046739A1	IMIDAZOLIDINONE DERIVATIVES AS INHIBITORS OF PERK The invention is directed to substituted imidazolidinone derivatives. Specifically, the invention is directed to compounds according to Formula I (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y1, Y2 and Z are defined herein. The compounds o...
WO/2017/042834A1	TRICYCLIC FUSED PYRIDIN-2-ONE DERIVATIVES AND THEIR USE AS BRD4 INHIBITORS The present disclosure describes heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceuti...
WO/2017/040879A1	THIAZOLO(3,2-A) PYRIMIDINONE AND OTHER HETEROBICYCLIC PYRIMIDINONE COMPOUNDS FOR USE IN MEDICAL THERAPY The invention provides heterobicyclic pyrimidinone compounds such as thiazolo[3,2-a]pyrimidinone compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical diso...
WO/2017/040993A1	SMALL MOLECULE INHIBITORS OF DYRK1A AND USES THEREOF This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a benzimidazole or imidazopyridine structure which function as inhibitors of DYRK1A protein, and their u...
WO/2017/040877A1	HETEROBICYCLIC PYRIMIDINONE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS The invention provides heterobicyclic pyrimidinone compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson's dise...
WO/2017/030892A1	HISTONE DEACETYLASE INHIBITORS AND METHODS FOR USE THEREOF The present invention relates to methods of modulating (for example inhibiting) activity of histone deacetylases (HDACs) and/or treating HDACs - associated diseases including, for example, cancers, inflammatory disorders, neurodegenerati...
WO/2017/025914A1	5-(N-FUSED TRICYCLIC ARYL TETRAHYDROISOQUINOLIN-6-YL) PYRIDIN-3- YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION Disclosed are compounds of Formula (I), including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infe...
WO/2017/025491A1	BACE1 INHIBITORS The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the pres...
WO/2017/025916A1	5-(N-[6,5]-FUSED BICYCLIC ARYL TETRAHYDROISOQUINOLIN-6-YL) PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION Disclosed are compounds of Formula (I), including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infe...
WO/2017/014323A1	1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof has an EP4 receptor antagonistic action, and is useful as an agent for the prophylaxis or...

Matches 851 - 900 out of 8,163	< 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 >