Steroids

Matches 651 - 700 out of 2,761	< 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 >

Document	Document Title
WO/1999/016785A1	METHOD FOR SEPARATING STEROLS FROM TALL OIL A method is set forth for separating a sterol or sterol ester from crude tall oil comprising fractionating the crude tall oil into a residue fraction and a volatile fraction, wherein the temperature of the residue fraction does not excee...
WO/1999/016452A1	THERAPEUTICALLY EFFECTIVE 1$g(a), 25-DIHYDROXYVITAMIN D¿3? ANALOGS Novel analogs of 1$g(a), 25-dihydroxyvitamin D¿3?, which are selective agonists for the genomic responses or agonists or antagonists for the rapid cellular responses in a wide array of diseases in which 1$g(a), 25-dihydroxyvitamin D¿3?...
WO/1999/015547A1	USE OF ORGANIC ACID ESTERS IN FOOD PRODUCTS The invention concerns beverage compositions and acetic acid compositions that contain hydroxy acid, keto acid, dicarboxylic acid or amino acid esters of a phytosterol and/or a phytostanol, or their salts, the amine salts of amino acid e...
WO/1999/015546A1	USE OF ORGANIC ACID ESTERS IN DIETARY FAT The invention concerns dietary fat compositions that contain the hydroxy acid or dicarboxylic acid or amino acid esters of a phytosterol and/or phytostanol, or the mixed esters formed with the alcohols, polyols or polyol (C¿2?...C¿22?)...
WO/1999/010318A1	AMINOPHENOL DERIVATIVES AND THEIR USE IN COSMETICS The invention concerns novel aminophenol derivatives, a composition containing them and their use in a composition as depigmenting and/or bleaching agent for human skin, hairs and/or hair. The invention also concerns a method for depigme...
WO/1999/007325A1	LIVER FUNCTION TEST A method of determining the liver function of a patient, comprises the steps of (i) processing a series of blood samples which have passed through the liver of the patient and which have been collected at timed intervals after introducin...
WO/1999/003503A1	THE USE OF ANGIOSTATIC STEROIDS IN PHOTODYNAMIC THERAPY Methods for treating ocular neovascularization using photodynamic therapy in combination with an angiostatic steroid are disclosed.
WO/1998/055126A2	USE OF ANTI-INFLAMMATORY STEROIDS FOR THE TREATMENT OF CHRONIC INFLAMMATORY INTESTINAL DISEASES The invention relates to the use of inflammatory compounds having general formula (I) wherein X is a member of the group consisting of H and halogen; Y is a member of the group consisting of H�2?, H(OH), H(O(C�1-6?)Acyl) and O; R�1...
WO/1998/055498A1	17$g(b)-ALLYLOXY(THIO)ALKYL-ANDROSTANE DERIVATIVES FOR THE MODULATION OF MEIOSIS The invention relates to 17$g(b)-allyloxy(thio)alkyl-androstane derivatives having general formula (I) wherein R�1? is (H, OR), (H, OSO�3?H) or NOR; with R being H, (C�1-6?)alkyl or (C�1-6?)acyl; each of R�2? and R�3? is inde...
WO/1998/052965A1	20-ARALKYL-5$g(a)-PREGNANE DERIVATIVES The invention relates to 20-aralkyl-5$g(a)-pregnane derivative having general formula (I), or a pharmaceutically acceptable salt thereof, wherein R�1? is (H,OR), (H,OSO�3?H) or NOR; R is H, (C�1-6?)alkyl or (C�1-6?)acyl; each of ...
WO/1998/038206A1	PROCESS FOR THE PREPARATION OF STANOL ESTERS The invention relates to a process for the preparation of stanol esters by hydrogenating a sterol blend in a hydrogenation solvent and at an elevated temperature in the presence of a hydrogenation catalyst, by removing the hydrogenation ...
WO/1998/028323A1	MEIOSIS REGULATING COMPOUNDS Certain compounds, structurally related to natural compounds which can be extracted $i(i.a.) from bull testes and from human follicular fluid, can be used for regulating the meiosis in ovocytes and in male germ cells.
WO/1998/024800A2	STEREOSELECTIVE SYNTHESIS OF 24-HYDROXYLATED COMPOUNDS USEFUL FOR THE PREPARATION OF AMINOSTEROLS, VITAMIN D ANALOGS, AND OTHER COMPOUNDS A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereose...
WO/1998/023580A1	POLYMERIZABLE OLIGOMESOGENES, The invention relates to compounds of the general formula (I) X[-Y�1?-A�1?-Y�2?-M-Y�3?-A�2?-Z]�n? in which X is a silicon free, n-bond central unit; the radicals A�1? and A�2? are, independently of one another, a direct b...
WO/1998/014194A1	STEROIDS AS NEUROCHEMICAL STIMULATORS OF THE VNO TO ALLEVIATE SYMPTOMS OF ANXIETY The invention relates to a method of alleviating the symptoms of anxiety. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor. The st...
WO/1998/003207A1	STEROIDS AS NEUROCHEMICAL STIMULATORS OF THE VNO TO ALLEVIATE SYMPTOMS OF PMS AND ANXIETY The invention relates to a method of alleviating the symptoms of PMS and anxiety. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithelial receptor...
WO/1998/002450A2	6,7-OXYGENATED STEROIDS AND USES RELATED THERETO Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have...
WO/1998/002187A1	PHARMACEUTICAL COMPOSITION CONTAINING ACID ADDITION SALT OF BASIC DRUG A pharmaceutical composition contains an acid addition salt of a basic drug and a fatty acid or bile acid. The acid addition salts thus formed exhibit enhanced transmucosal and transdermal penetration of the basic drug. The acid addition...
WO/1998/002161A1	DEOXYNOJIRIMYCIN DERIVATIVES AND THEIR USES AS GLUCOSYLCERAMIDASE INHIBITORS Deoxynojirimycin derivatives containing a large hydrophobic moiety, such as cholesterol or adamantame-methanol, linked through a spacer, such as pentamethylene, to the nitrogen atom of deoxynojirimycin, and salts thereof, inhibit glucosy...
WO/1998/002186A1	INCLUSION COMPLEX CONTAINING INDOLE SELECTIVE SEROTONIN AGONIST An inclusion complex comprises (a) an indole selective serotonin (5-HT�ID?) agonist or a pharmaceutically acceptable salt thereof, such as for example sumatriptan, and (b) unsubstituted or substituted beta- or gamma-cyclodextrin, such ...
WO/1998/001126A2	METHOD OF MANUFACTURING A STEROL ESTER MIXTURE Process for the manufacture of a mixture of fatty acid esters comprising the steps of: (a) hydrolysing a sterol ester or a mixture of sterol esters such that a mixture is obtained comprising phenolic acids and/or fatty acids, and free st...
WO/1998/000397A1	CRYSTALS OF VITAMIN D DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF A crystal of the compound of the structural formula (I); crystals of vitamin D derivatives prepared by purifying unpurified or roughly purified vitamin D derivatives by reversed phase chromatography and crystallizing the purified derivat...
WO/1997/046574A1	19-NOR-CHOLANE STEROIDS AS NEUROCHEMICAL INITIATORS OF CHANGE IN HUMAN HYPOTHALAMIC FUNCTION The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor cholane steroid, or a pharmaceutical composition containing a vomeropher...
WO/1997/045440A1	CYTOSTATIC STEROLS Compounds of formula (I) wherein X is a straight or branched, hydroxy substituted C1-C15 hydrocarbon chain, have utility in the treatment of conditions associated with rapidly growing cells and cancers such as melanoma.
WO/1997/042215A1	PROCESS FOR PREPARING 27-HYDROXY CHOLESTEROL AND RELATED DERIVATIVES A process for preparing 27-hydroxy cholesterol and derivatives thereof. The process includes the conversion of the terminal acid or ester moiety to a reactive halomethyl moiety, which is eventually reduced to a hydroxy moiety after alkyl...
WO/1997/041145A1	21-SUBSTITUTED PROGESTERONE DERIVATIVES AS NEW ANTIPROGESTATIONAL AGENTS A compound having general formula (I) in which R1 is a member selected from the group consisting of -OCH3, -SCH3, -N(CH3)2, -NHCH3, -CHO, -COCH3 and -CHOHCH3; R2 is a member selected from the group consisting of halogen, alkyl, acyl, hyd...
WO/1997/039018A1	NEW PREGNANE DERIVATIVES WITH NO ALPHA-17 SUBSTITUTENT, THEIR MEDICINAL USE, MANUFACTURING METHOD AND ITS INTERMEDIARIES AND RELATED COMPOUNDS The invention discloses products with formula (I) in which: either R1 stands for halogen, hydroxyl, (C1-C8) alkyloxy or (C1-C12) acyloxy, and R2 represents halogen or hydrogen; or R1 and R2 together form a double bond, Z is selected from...
WO/1997/036596A1	STEROIDS AS NEUROCHEMICAL INITIATORS OF CHANGE IN HUMAN BLOOD LEVELS OF LH OR FSH The invention relates to a method of altering the blood levels of LH or FSH in an individual. The method comprises nasally administering a steroid which is a human vomeropherin, such that the vomeropherin binds to a specific neuroepithel...
WO/1997/034917A1	PROCESS FOR HYDROGENATING UNSATURATED PLANT-BASED COMPOUNDS AND REGENERATION OF A USED CATALYST The invention relates to a process for catalytic hydrogenation of non-hormonal unsaturated plant steroids and unsaturated plant-based fatty acids and triglycerides thereof using a metal catalyst bound to a polymer support containing graf...
WO/1997/028180A1	ANTIFUNGAL AGENT There is disclosed a novel compound having formula (I) which exhibits antifungal activity.
WO/1997/003686A1	TNF RECEPTOR AND STEROID HORMONE IN A COMBINED THERAPY The present invention relates to the use of a TNF Receptor together with a steroid hormone to produce a pharmaceutical composition for the treatment of lethal bacterial and viral infections as well as autoimmune and inflammatory diseases...
WO/1997/003033A1	PREPARATION OF ALDEHYDES OR KETONES FROM ALCOHOLS A process for preparing an aldehyde or ketone comprising reacting a primary or secondary alcohol with oxygen in the presence of a base, a catalytic amount of a copper salt and a suitable lignad under anhydrous conditions.
WO/1997/000883A1	MEIOSIS REGULATING COMPOUNDS A compound of general formula (I) wherein R1, R2 and R3, independently, are hydrogen or methyl; and R4 and R5 are either hydrogen or together designate an additional bond between the carbon atoms to which they are bound can be used for r...
WO/1997/000884A1	MEIOSIS REGULATING COMPOUNDS Certain sterol derivatives, structurally related to natural compounds which can be extracted i.e. from bull testes and from human follicular fluid, can be used for regulating the meiosis in oocytes and in male germ cells.
WO/1996/040154A1	USE OF VITAMIN D4 DERIVATIVES FOR TREATING SKIN DISORDERS Novel 1'alpha'-hydroxy vitamin D4 and novel analogues, 1,25 dihydroxy vitamin D4 and 1,24 dihydroxy vitamin D4 which are useful as active compounds of pharmaceutical compositions for the treatment of disorders of calcium metabolism and v...
WO/1996/040726A1	NOVEL CARBAMATE-BASED CATIONIC LIPIDS The present invention provides novel carbamate-based cationic lipids of general structure (I) or a salt, or solvate, or enantiomers thereof wherein: (a) R1 is a lipophilic moiety; (b) R2 is a positively charged moiety; (c) n is an intege...
WO/1996/040725A1	PHOSPHONIC ACID-BASED CATIONIC LIPIDS The present invention provides novel phosphonic acid-based cationic lipids of general structure (I), or a salt, or solvate, or enantiomers thereof wherein: (a) R1 is a lipophilic moiety; (b) R2 is a positively charged moiety; (c) R3 is a...
WO/1996/040151A1	USE OF SQUALAMINE FOR THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING NHE Aminosterol compounds are described that are useful as inhibitors of the sodium/proton exchanger (NHE). Methods of using such aminosterols compounds are also enclosed, including those employing compounds that are inhibitors of a spectrum...
WO/1996/040727A1	NOVEL NOR-PREGNANES FOR INDUCING HYPOTHALAMIC EFFECTS The invention relates to a method of altering hypothalamic function in an individual. The method comprises nasally administering a human vomeropherin, e.g. a 19-nor-pregnane steroid, or a pharmaceutical composition containing a vomerophe...
WO/1996/038464A1	ANTIMICROBIAL STEROL CONJUGATES The invention discloses steroid conjugates having structures (I) or (II) where Y is NHCH2CH2CH2CH2NH2, NH(CH2)3NH(CH2)4NH(CH2)3NH2, or NHCH2CH2NHCH2CH2NHCH2CH2NH2, and each of R1, R2, R3 and R4 is individually H, OH and OSO3H. These conj...
WO/1996/035707A1	TERPENOID INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention an...
WO/1996/022973A1	2-SUBSTITUTED VITAMIN D3 DERIVATIVES A compound represented by general formula (I), wherein R1 and R2 are the same or different and each represents C1-4 alkyl; and R3 represents C1-7 alkoxy optionally substituted by hydroxy, halogeno, cyano, C1-4 alkoxy, amino or acylamino;...
WO/1996/017823A1	LIPOPOLYAMINES AS TRANSFECTION AGENTS AND PHARMACEUTICAL USES THEREOF Cationic lipids of general formula (I), wherein m is an integer from 2 to 6 inclusive; n is an integer from 1 to 9 inclusive, preferably 1-5, where, when n is 2-9, a single R grouping other than hydrogen is present in the general formula...
WO/1996/017859A1	PROCESS FOR PREPARING ISOURSODESOXYCHOLIC ACID The invention concerns a process for preparing isoursodesoxycholic acid, wherein the ursodesoxycholic acid is first esterified and the resultant ursodesoxycholic acid ester is reacted by the Mitsunobu reaction to form isoursodesoxycholic...
WO/1996/016076A1	ANDROSTANE AND PREGNANE SERIES FOR ALLOSTERIC MODULATION OF GABA RECEPTOR Methods, compositions, and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
WO/1996/013474A1	METHOD OF CONVERTING HYDROXYL GROUPS INTO CORRESPONDING FLUORO COMPOUNDS The method described calls for primary and secondary alcohols to be reacted with perfluorobutane sulphonyl fluoride, or with higher homologues such as perfluorooctane sulphonyl fluoride, in the presence of 2-3 equivalents of strong organ...
WO/1996/012817A1	COMBINATION METHOD FOR ACNE TREATMENT Described is a combination method using selective inhibitors of 5'alpha'-reductase 1 and/or 2 including 7'beta'-substituted 4-aza-5'alpha'-cholestan-3-ones and related 4-aza-5'alpha'-androstan-3-one compounds which are useful in the trea...
WO/1996/012494A1	COMPETITIVE PROGESTERONE ANTAGONISTS FOR REGULATING FEMALE FERTILITY AS REQUIRED The present invention concerns the novel use of competitive progesterone antagonists in the preparation of a drug for regulating female fertility as required (pill to be taken as required). This drug can be administered in a single dose ...
WO/1996/012705A1	7-SUBSTITUTED 4-AZA CHOLANIC ACID DERIVATIVES AND THEIR USE Compounds of formula (I) wherein: the dotted line indicates that a double bond may be present or absent; R1 is H, methyl or ethyl; R2 is 'alpha'- or 'beta'-C1-10 straight or branched alkyl; R3 is CO2H, CN, CO2R4, COHNR4, or CON(R4)2; R4 ...
WO/1996/012487A1	COMBINATION METHOD FOR ACNE TREATMENT Described is a combination method using selective inhibitors of 5'alpha'-reductase 1 and/or 2 including 7'beta'-substituted 4-aza-5'alpha'-cholestan-3-ones and related 4-aza-5'alpha'-androstan-3-one compounds which are useful in the trea...

Matches 651 - 700 out of 2,761	< 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 >