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Matches 601 - 650 out of 4,292

Document Document Title
WO/2011/138641A1
A construct comprising a Ni and/or Au substrate provided of hexa-histidine-tagged protein A or G suitable for building a layer of antibodies featuring an enhanced antigen binding ability, wherein said hexa-histidine- tagged protein A or ...  
WO/2011/127585A1
The present invention relates to a method for diagnosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a sample of a subject by detecting oncogenic and cancer related...  
WO/2011/118599A1
Provided are a filler for affinity chromatography which is highly tolerant to alkalis, and a method for isolating immunoglobulin. The filler for affinity chromatography is a filler wherein a protein represented by general formula (1) is ...  
WO/2011/109298A2
DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL...  
WO/2011/102342A1
Disclosed are an antibody-immobilized carrier capable of use in antibody screening, a method of producing the antibody-immobilized carrier, and use of said antibody-immobilized carrier. The antibody-immobilized carrier is provided indepe...  
WO/2011/091286A1
The present invention relates to surprisingly effective anti-cancer drug combinations, pharmaceutical compositions comprising the same, and uses thereof in the treatment of ovarian cancer. In particular, the present invention is based on...  
WO/2011/003085A9
The invention features HYR1 as a vaccine target and as a prophylactic strategy for combating disseminated candidiasis.  
WO/2011/089903A1
The object of the present invention is to provide a method for increasing an amount of Protein A to be immobilized on the self-assembled monolayer. Immobilizing Protein A to the self-assembled monolayer through the structure represented ...  
WO/2011/083735A1
Provided are a composite material, wherein a metal is carried in a pore of a protein crystal, and a method for producing the same.  
WO/2011/085231A2
Disclosed are compositions and related methods that involve a synthetic nanocarrier that includes at least one peptide obtained from Human papillomavirus L1 or L2 capsid protein; wherein the peptide is coupled to an external surface of t...  
WO/2011/084705A2
This invention provides novel reagents for cyanating polysaccharides in aqueous or part aqueous solutions so that they may be covalently linked to proteins either directly or through a spacer. These reagents include l-cyano-4-pyrrolidino...  
WO/2011/060528A1
Reagents, kits, uses and methods useful for example fo decreasing nonspecific adsorption of biomolecules at the surface of a solid support are disclosed. Such reagents and methods, which are based on short heteropeptides, may be used to ...  
WO/2011/063127A1
The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of m...  
WO/2011/058315A2
The invention relates to a glucose binding protein comprising amino acid mutations relative to the wild type sequence at the following positions: (i) H 152, (ii) A213; and (iii) L238 wherein the mutation at position H 152 is H152C. The i...  
WO/2011/055682A1
Disclosed are: a multilayer transparent light-receiving element which can be easily produced, while having extremely high optical response speed; and a high-performance electronic device which uses the multilayer transparent light-receiv...  
WO/2011/041897A1
The present invention is directed to conjugates that include a polypeptide capable of crossing the blood-brain barrier or entering one or more cell types attached to a transport vector, i.e., a compostion capable of transporting an agent...  
WO/2011/041906A1
The present invention relates to a method for covalently attaching a compound to a stainless steel, tin, iron, or titanium substrate, by contacting exposed surface(s) of the substrate with a synthetic pilin peptide containing a disulfide...  
WO/2011/040823A1
The present invention relates to novel synthetic myostatin antagonists, comprising a synthetic mature myostatin peptide, wherein the peptide comprises at least two cysteine residues at positions 281 and 282 which are forced to bond and f...  
WO/2011/037896A2
The invention provides methods for the PEGylation of an N-terminal cysteine of a polypeptide such that the thiol group of the cysteine is unreacted in the final PEGylated polypeptide. In one embodiment, the invention comprises a method o...  
WO/2011/030682A1
Disclosed is a construct comprising a virus coat-constituting protein, which is usable as a drug delivery carrier applicable to various drugs. Specifically disclosed is a construct coated with a virus coat-constituting protein which is c...  
WO/2011/026351A1
A cyanovirin N (CVN) mutant, its PEG modified derivative and their uses in preparing drugs. The said cyanovirin N mutant is composed of sequence A and sequence B: sequence A is a linker peptide with hydrophilicity and flexibility, sequen...  
WO/2011/022824A1
A method is provided for optical protein patterning by photobleaching using a microscope having an objective and a camera port, the objective and the camera port defining respective focal planes. The method comprises positioning a substr...  
WO/2010/101526A9
Described is a new standalone diguanylate cyclase polypeptide having a GGDEF motif and a mutated I-site that does not bind c-di-GMP. We demonstrate that the production yield of c-di-GMP and analogues was significantly increased by mutati...  
WO/2011/025158A2
The present invention relates to a coacervate including the adhesive protein of a mussel and an ionic polymer, and particularly, to a coacervate prepared by mixing the adhesive protein of a mussel and an ionic polymer, and to a novel use...  
WO/2011/017101A2
This invention is directed to processes for reducing the level of free carbohydrate from a solution of protein-linked carbohydrate (conjugate) and non-linked carbohydrate. In this process, the conjugate is adsorbed to a hydrophobic membr...  
WO/2011/015530A2
The invention relates to a process for the deposition of a metal oxide, such as titanium dioxide, as a thin layer on a substrate, by using particular biopolymers, in particular hydrophobin. The process for the deposition of a metal oxide...  
WO/2011/017514A1
The present invention relates, at least in part, to improved methods of protein purification. In particular, the present invention relates, at least in part, to methods for purifying an Fc region containing protein from a composition com...  
WO/2011/010964A1
Techniques for differentiating isobaric species are described. An isobaric species may be substituted with a tagging species identified using mass spectrometry. The isobaric species may be a subunit of a first polymer having a defined se...  
WO/2010/150375A1
Disclosed is a modified biotin-conjugated protein which is characterized by having any one substitution selected from the group consisting of items 1) to 6) shown below in a protein which comprises the amino acid sequence depicted in SEQ...  
WO/2010/142035A1
The present invention relates to a compound that includes a peptide vector, such as angiopep-2 which acts as a carrier across the blood-brain barrier, linked to glial-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor ...  
WO/2010/143983A1
Methods for the diagnosis of infection with Treponema palladium using a peptide-spacer-lipid construct are disclosed, where the spacer covalently links the peptide to the lipid. The peptide is a peptide comprising the sequence AlaSerGlyA...  
WO/2010/142850A1
In the field of drug or nutrient administration novel particles and formulations thereof are provided. Said particles each have a core comprising active agent and at least partial coating comprising proteins, selected from hydrophobins. ...  
WO/2010/138486A1
The present invention provides substrates useful for culturing cells under low serum or serum free conditions. The substrates are useful for conducting cell-based assays where there is interference from serum proteins. Methods are also p...  
WO/2010/135800A1
A silicon substrate for use in biosensing applications is provided, having a protective layer made of a hydrophobic dendrimer monolayer linked to a hydrophilic layer presenting biomolecule probes. The hydrophobic monolayer inhibits oxida...  
WO/2010/136617A1
The present invention relates to an amphiphilic polymeric conjugate that comprises general formula I, to the synthesis thereof and to the use of same as a drug for treating bacterial infections.  
WO/2010/138522A2
The present invention relates to embedding live or dead microorganisms and/or bioactive materials in a protective dry formulation matrix, wherein the formulation includes the bioactive microorganism or material, a formulation stabilizer ...  
WO/2010/134084A1
The present invention relates to a method of purifying human growth hormone from a mixture containing at least one related impurity; and a purified growth hormone with purity of at least 85%.  
WO/2010/019725A9
Engineered proteins are used in the assembly of two-dimensional and three-dimensional nanostructure assemblies, based on systematic design and production of protein node structures that can be interconnected, for example, with streptavid...  
WO/2010/126115A1
Disclosed is a method for screening an antibody which is to be co-crystallized with a membrane protein. Specifically disclosed is a liposome-membrane protein complex which is used for screening an antibody to be co-crystallized with a me...  
WO/2010/121352A1
A combination therapy is described comprising the CYP-metabolized compound Simvastatin and the growth hormone releasing factor (GRF) analogue (hexenoyl trans-3)hGRF(l-44)NH2 (tesamorelin), for the treatment of HIV- associated lipodystrop...  
WO/2010/121559A1
The invention provides a novel exendin variant and the exendin variant conjugate conjugating polymer thereon, the pharmaceutical composition comprising them and use of them for treating diseases such as reducing blood glucose, treating d...  
WO/2010/121351A1
A combination therapy is described comprising the protease inhibitor Ritonavir and the growth hormone releasing factor (GRF) analogue (hexenoyl trans-3)hGRF(1-44)NH2 (TH9507), for the treatment of HIV- associated lipodystrophy. Human gro...  
WO/2010/118985A1
The present application relates to an affinity material useful in antibody purification.  
WO/2010/115835A2
The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules ...  
WO/2010/114031A1
Disclosed are: a method for detecting a substance in a biological sample; a carrier for use in the method; and a kit. The method comprises the following steps 1) to 4): 1) providing a carrier having a biotin-binding protein bound thereto...  
WO/2010/109284A1
In some aspects, the present invention provides ultrashort lipopeptides which feature ß -amino acids or ß-peptides and demonstrate antimicrobial activity. Accordingly, some aspects of the present invention provide lipopeptide compositi...  
WO/2010/101694A1
The invention in suitable embodiments is directed to dynamic bio-nanoparticle elements and bio-nanoparticle platforms employing such bio-nanoparticle elements. In one aspect, one or more elements of one or more types, formed from isolate...  
WO/2010/101886A1
The present invention relates to methods and compositions for the treatment of cancer. The methods and compositions involve the use of the Salmonella effector protein AvrA, as well as variants or fragments thereof, or encoding nucleic ac...  
WO/2010/099515A2
The present invention creates an immunologically protected/enhanced space in vivo in a mammal by removing the impact of soluble inhibitors of the mammal's immune system in a defined space within the body. Placing an antigen source within...  
WO/2010/091122A1
The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and...  

Matches 601 - 650 out of 4,292