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WO/2007/059242A1 |
Low-density lipoprotein receptor-related protein 2 (LRP2) is a potential receptor to regulate the level of apolipoprotein J (apoJ) in the central nervous system, which is the major carrier of amyloid-β peptide (Aβ). ApoJ is cleared fro...
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WO/2007/054030A1 |
Polyethylene glycol modifications of thymosin alpha-1 (Tα1-PEGs), their preparation process, the medicine composition containing them, and their application in the medicine for preventing and treating diseases related with immune defici...
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WO/2007/055178A1 |
In a method of cell fractionation according to the invention, by using a ligand-presenting substrate in which a ligand capable of temporarily binding to a receptor present on the surface of a cell desired to be fractionated is immobilize...
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WO/2007/051605A2 |
The invention relates to methods for examining the enzymatic cleavability of substrates. In the methods, compounds, which have a cleavability of the section to be examined, are firstly synthesized on a first solid phase, separated theref...
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WO/2007/050702A2 |
Disclosed herein are immunogenic compositions comprising a multilayer film comprising two or more layers of polyelectrolytes, wherein adjacent layers comprise oppositely charged polyelectrolytes. A first layer polyelectrolyte comprises a...
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WO/2007/050569A2 |
Polypeptide multilayer films comprising a hydrophobic designed polypeptide, methods of making the polypeptide multilayer films, and methods of designing the hydrophobic polypeptide are disclosed.
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WO/2007/046520A1 |
Disclosed are: a method for screening a protein capable of interacting with a target substance, comprising the steps of: (a) linking between mRNA and an immobilized puromycin linker that is immobilized on a solid phase to prepare an immo...
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WO2006125140A9 |
The present invention is directed to methods for treating fibrosis conditions, such as liver, kidney and lung fibrosis, as well as fibrosis conditions of other tissues of the body. The methods of the invention comprise administering to a...
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WO/2007/028290A1 |
Human membrane antigen coated with magnetic particle and the method for preserving it are provided.The method includes following steps: preparing erythrocytic antigen, preparing magnetic particle,and coating the antigen with magnetic par...
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WO/2007/026972A2 |
A binding protein molecule, characterized in that it has a first domain having a binding site to an inhibitor of non-specific adsorption in which the domain comprises a part of the variable region of an antibody as the binding site and a...
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WO2006072048B1 |
The disclosure relates to compositions and methods for modulating the biological activity of HAUSP protein. Among the activities that can be modulated are binding of HAUSP protein with proteins such as p53, MDM2, and EBNA1; modulation of...
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WO/2007/023915A1 |
Disclosed is an imprint polymer having a recognition site which is reversibly bound to a target protein. Since the recognition site has at least one of a metal complex and a substrate inhibitor, the imprint polymer can have a high specif...
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WO/2007/021016A1 |
A method for photoregulating the formation of a complex between a protein of interest and a peptide capable of recognizing the protein, wherein a structural change in the peptide that is used for the recognition of the protein is photore...
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WO/2007/021253A1 |
The inventors have discovered that an ATPase-deficient dominantnegative mutant NS3 protein of hepatitis C virus inhibits activity of the wild-type NS3 protein and inhibits replication of hepatitis C virus (HCV). The solved crystal stru...
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WO/2007/020880A1 |
A method of producing lymphocytes characterized by comprising the step of performing enlarged culture in the presence of (a) fibronectin, its fragment or a mixture thereof, (b) CD3 ligand and (c) CD28 ligand.
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WO/2007/014447A1 |
The present invention concerns the gelation of an undenatured protein and a polysaccharide dispersions by a gradual pH adjustment of their mixture The final pH of the mixture is close to or lower than the isoelectric point of the protein...
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WO/2007/012605A2 |
The invention discloses a static support bed (SSB) for purification, separation, detection, modification, and/or immobilization of target chemical entities or target biological entities present in a fluid. The static support bed of the p...
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WO/2007/012144A1 |
A method of propagating embryonic stem (ES) cells in an undifferentiated state, while maintaining both the pluripotency and the cells normal genotype is disclosed. The method comprises using recombinantly produced protein domains to atta...
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WO/2007/010623A1 |
A novel polypeptide of the invention contains a peptide unit having an amino acid sequence represented by the following formula (1) and a peptide unit having an amino acid sequence represented by the following formula (2). -Pro-X-Gly- (1...
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WO/2007/003781A1 |
The invention relates to fluorescent polymers soluble in an aqueous solution carrying at least 5 fluorophores which are distributed on a polymer and exhibit the following properties: fluorophores are water-soluble, the fluorophores are n...
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WO/2007/000972A1 |
Disclosed is a novel tag which is used for the modification of a target protein. Also disclosed is a means for capturing the target protein using the tag. Specifically, study is made on a novel tag for a protein based on the knowledge ab...
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WO/2007/002482A1 |
Compositions and methods for identifying modulators of RUFY2 are described. The methods are particularly useful for identifying analytes that antagonize RUFY2’s effect on processing of amyloid precursor protein to Aβ peptide and thus ...
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WO/2007/000163A1 |
The present invention relates generally to methods and carriers for cross-linking or immobilising biomolecules such as polypeptides. In particular, the present invention relates to methods and carriers useful for coupling a polypeptide t...
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WO/2006/138721A1 |
Antibodies and antibody fragments that bind to the receptor GFRalpha3 and inhibit formation of a Neublastin-GFRalpha3-Ret ternary complex are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to inhibit...
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WO/2006/138272A1 |
A method for immobilizing unmodified material using a metal-ion approach is provided wherein the material is immobilized on a surface in an active state on surface features coupled with metal-ions.
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WO/2006/134379A1 |
The present invention provides a method of forming an ion of formula (I) comprising the steps of: (i) reacting a compound of the formula (IIa); with a biopolymer, BP, having at least one group capable of reacting with M to form a covalen...
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WO/2006/131080A1 |
The invention relates to immunodiagnostics and, in particular, to the area dedicated to protein microarrays. The invention is also linked to immunochemistry and immunofluorescent assays for the detection of different analytes. The invent...
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WO/2006/129796A1 |
It is intended to provide a support for carrying magnetic particles which enables an improvement in the dispersion properties of magnetic particles in a nanosize without worsening the characteristics of the nanosize magnetic particles (f...
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WO/2006/128027A1 |
A method is disclosed for inhibiting angiogenic activity by interacting anginex with the peptide galectin-1. Also disclosed is a method for constructing an artificial gene encoding the biologically exogenous peptide anginex and producing...
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WO/2006/119285A1 |
Disclosed herein is a method of treating a tumor by administering to the subject a treatment effective amount of a therapeutic antibody and an alkylating agent.
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WO/2006/116948A1 |
A interleukin-6 polyethylene glycol conjugate and its preparing method and medical compositions comprising the conjugate and pharmaceutically acceptable excipients. The conjugate according to the invention is used for producing medicines...
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WO/2006/117227A2 |
A method for the solid phase peptide synthesis of thymosin alpha-1 is disclosed. The peptide or fragments thereof are synthesised on a polyehtylene glycol (PEG) resin. The method provides high yields and pure products.
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WO/2006/113958A2 |
Disclosed is an affinity matrix comprising a solid phase and an affinity ligand comprising peptide bonds coupled to this solid phase, wherein the affinity ligand comprising peptide bond is selected from the following group of ligands: a)...
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WO/2006/108594A1 |
A novel method for solid phase synthesis of peptides is disclosed. The method is particularly useful for peptides or peptide segments having strong propensity for forming &agr -helix secondary structure element.
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WO/2006/097694A2 |
A process for preparing a peptide or protein by solid phase synthesis comprising combining a sequence including one or more amino acids linked to a first resin via the C terminal, with an amino acid sequence including one or more amino a...
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WO/2006/097693A1 |
A process for preparing a peptide or protein by solid phase synthesis comprising combining a sequence including one or more amino acids obtainable by C-N synthesis linked to a first resin, with an amino acid sequence including one or mor...
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WO/2006/096847A1 |
The invention relates to polypeptides referred to herein as obestatin. Obestatin, analogs and mimetics thereof act in signaling pathways, and are shown to modulate hypertension and other cardiovascular parameters, and gastric emptying.
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WO/2006/092043A1 |
Emitters, compositions, and processes and methods for making emitters and compositions, useful for emitting sample for mass spectral analysis and/or acting as a stationary phase in chromatographic applications are described. Compositions...
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WO/2006/093794A1 |
The invention relates to methods for making modified immunoglobulin compositions to maximize antigen binding and effector function by swapping of sequences of the heavy and light chains within an IgG Fab domain for the purpose of reorien...
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WO/2006/094200A2 |
The present invention comprises a method of using a peptidoconjugate for cellular imaging. The method comprises providing a peptidoconjugate having an imaging agent and a peptide wherein a specific combination of the imaging agent and th...
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WO/2006/088214A1 |
A microactuator is fabricated by holding myosin on the surface, loading bundled actin filaments thereon to form a protein construct and three-dimensionally processing the surface so as to allow the bundled actin filaments to serve as an ...
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WO/2006/084888A2 |
Conjugated growth hormones of the structure (I) are provided together with methods for manufacturing said conjugates. The conjugates are useful in therapy.
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WO/2006/083276A2 |
The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells contai...
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WO/2006/083016A1 |
Disclosed is means for determining the reactivity of a protein kinase or a protein phosphatase in a simple manner. Substrates for a protein kinase, each comprising at least one artificial peptide substrate which is produced by substituti...
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WO/2006/080895A1 |
The invention provides a process for the preparation of a surface-functionalized nanoparticle comprising: (a) reacting a nanoparticle with a functionalized silane and a base in a substantially non-aqueous solvent to obtain a partially co...
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WO/2006/076691A2 |
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vec...
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WO/2006/072140A1 |
The invention relates to separating molecules, in particular, to proteins comprised in biological fluid such as serum, to purifying molecules and to producing antisera to molecules.
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WO/2006/071132A1 |
The invention relates to biochemistry, medicine and molecular biology, in particular, to analytical biochemistry and immunoassay, more specifically to a biological microchip for the multiple parallel immunoassay of compounds. The inventi...
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WO/2006/066065A2 |
The inventions provide an isolated antiviral peptide characterized by the amino acid sequence GDEPLENYLDTEYF (SEQ ID:NO 1) and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41 and human CD4 cells. It has postulated anti...
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WO/2006/048473A1 |
The invention relates to a compound having formula I: cyclo[Arg-Gly-Asp-(beta-Lactam)] (I), containing at least one &gammad turn, wherein (beta-Lactam)- is a fragment of 3-amino-1-(2-carbonylmethyl)-azetidinone having formula II (II) in ...
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