| Document |
Document Title |
|
WO/2002/032963A1 |
This invention relates to compounds of general formula I, in which S is a carbohydrate core matrix; a is a pharmaceutically active moiety; L is a linker a covalent bond; n is an integer of 2 to 19; and R' is hydrogen, thioalkyl or X-Z in...
|
|
WO/2002/033116A2 |
Methods are provided for generating nucleic acid ligands of Prostate Specific Membrane Antigen (PSMA). The methods of the invention use the SELEX method for the isolation of nucleic acid ligands. The invention also includes nucleic acid ...
|
|
WO/2002/028895A2 |
The invention concerns cyclic peptides, the method for preparing them and their use as angiogenesis inhibitor or activator. Said cyclic peptides comprise the following peptide sequence: -Arg-Ile-Lys-Pro-Gln-Gly-. They can also be used in...
|
|
WO/2002/028437A1 |
A method is described for a method for the regioselective liquid-phase pegylation of GRF, which increases the yield of the GRF-PEG conjugate having 1 PEG molecule covalently bound to the e-amino group of Lys?12¿. This method is characte...
|
|
WO/2002/024325A2 |
The present invention provides a method and device (11) for the acoustic ejection of fluid droplets (49) from each of a plurality of fluid-containing reservoirs (13, 15). The droplets (49) are ejected toward sites on a substrate surface ...
|
|
WO2000043791A9 |
Methods, assays, and components are described in which biological samples can be rapidly and sensitively analyzed for the presence of species associated with neurodegenerative disease. Techniques and components are provided for diagnosis...
|
|
WO/2002/020033A1 |
The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The i...
|
|
WO/2002/020034A1 |
The present invention concerns methods and compositions for extending the technique of native chemical ligation of a wider range of peptides, polypeptides, other polymers and other molecules via an amide bond (see Figure 1). The inventio...
|
|
WO/2002/019963A2 |
Synthetic erythropoiesis stimulating proteins are provided. Also provided are methods for synthesizing the proteins. The invention further relates to derivatives of such synthetic erythropoiesis stimulating proteins that are polymer-modi...
|
|
WO/2002/018443A2 |
A purified or highly pure recombinant monoclonal antibody with 4G10-hybridoma type specificity is disclosed along with polynucleotides, including cDNA sequences, encoding the antibody chains and the amino acid sequences corresponding to ...
|
|
WO/2002/016571A1 |
Magnetic particles having a lower limit critical solution temperature and carrying at least one substance selected from biotin and avidin immobilized thereto; a method of converting a substance by using the same; a method of separating o...
|
|
WO/2002/016945A1 |
A chemical sensor consisting of a microcartridge having a microchannel formed thereon, a sensor chip provided on the microcartridge, and a prism provided on this sensor chip. In the sensor chip, a metal film is formed on one face of the ...
|
|
WO/2002/013775A1 |
Dental products such as toothpastes, mouthwash and dental floss are disclosed which products are enhanced by having dissolved, dispersed or coated thereon a compound which promoted bone growth. Preferred compounds are peptide sequences c...
|
|
WO2000073337A9 |
A hedgehog polypeptide comprising hedgehog coupled to a polymer containing a polyalkylene glycol moiety wherein the hedgehog and the polyalkylene glycol moiety are arranged such that the hedgehog has an enhanced bioavailability relative ...
|
|
WO/2002/012893A2 |
Disclosed are products and methods to facilitate the identification of compounds that are capable of interacting with biological macromolecules of interest, especially when such macromolecules are attached to a support surface in microar...
|
|
WO/2002/010218A1 |
Biomacromolecules encapsulated or immobilized within mesoporous or nanoporous materials via surfactant-templated sol-gel reactions and methods for producing these encapsulated 5 or immobilized biomacromolecules are provided.
|
|
WO/2002/009793A1 |
The invention relates to a device for treating immune diseases, comprising an incoming line for blood and/or aqueous components thereof, which can be connected to a blood withdrawal site on the human body, an outgoing line which can be c...
|
|
WO2000072869A9 |
Disclosed herein is a method for generating a 5'-nucleic acid-protein conjugate, the method involving: (a) providing a nucleic acid which carries a reactive group at its 5'end; (b) providing a non-derivatized protein; and (c) contacting ...
|
|
WO/2002/007707A2 |
Methods, products and kits are provided for attaching agents to a skin surface via microparticles using endogenous or exogenous transglutaminase.
|
|
WO/2002/006384A1 |
The present invention relates generally to new surfaces for solid phase chemistry applications, more specifically plastics surfaces modified by graft polymerisation for use in chemical synthesis and/or immobilisation of chemical entities...
|
|
WO/2001/098324A1 |
Disclosed are a variety of peptide conjugates represented by the following general formula (I): R¿1?-Z-X-Z'-R¿2?, wherein X represents a hexapeptide of the formula (II): A?1¿-A?2¿-A?3¿-A?4¿-A?5¿-A?6¿ wherein A?1¿ represents Arg,...
|
|
WO/2001/098497A1 |
The present invention provides novel Secreted Epithelial Colon Stromal-1 (Secs-1) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for produ...
|
|
WO/2001/098458A2 |
This invention provides methods for immobilizing polypeptides, for forming arrays of polypeptides arranged on a support, and arrays produced using the methods of the invention. The immobilized polypeptides of the invention are generally ...
|
|
WO/2001/098362A2 |
Compositions and methods for inhibiting and controlling the growth of microbes are disclosed. The composition comprises at least one chemically-modified peptide with antimicrobial activity and at least one carrier. The method comprises o...
|
|
WO/2001/092452A1 |
There is provided a process for binding an antigen to a molecule having a high binding affinity to said antigen, characterised in that the binding is carried out in a medium having a water content of less than 25 % by weight of the total...
|
|
WO/2001/092883A2 |
The invention relates to binding surfaces for the immobilisation of ligands, ligand surfaces and structured surface arrays which present a number of similar or differing ligands. The invention further relates to a method for the producti...
|
|
WO/2001/083827A1 |
The present invention relates to protein chips useful for the large-scale study of protein function where the chip contains densely packed reaction wells. The invention also relates to methods of using protein chips to assay simultaneous...
|
|
WO/2001/081425A1 |
The invention concerns the use of a secondary cell wall polymer for oriented monomolecular bonding of molecular layers and/or addition of molecules of a carrier. The invention also concerns a composite body produced according to the inve...
|
|
WO/2001/077182A1 |
An antibody/carrier complex which makes it possible to easily control the sensitivity in an antigen-antibody reaction without newly constructing an antibody. This antibody/carrier complex is a complex containing at least one antibody and...
|
|
WO/2001/077687A2 |
Disclosed are short peptide ligands that bind to regions of the prion peptide and methods of using same. They are derived from the screening of peptide libraries and can be used for diagnostic purposes or for removing prions from environ...
|
|
WO/2001/076662A1 |
Adsorbents, an adsorption apparatus and an adsorption method whereby an antibody against $g(b)1 adrenoreceptor and/or an antibody against M2 muscarine receptor present in body fluids (blood, plasma, etc.) can be efficiently and selective...
|
|
WO/2001/077676A1 |
Newly identified mammalian taste-cell-specific G protein-Coupled Receptors and the genes encoding said receptors are described. Specifically, T2R taste G Protein-Coupled Receptors that are believed to be involved in bitter taste sensatio...
|
|
WO/2001/066164A1 |
Matrices formed of materials which bind to growth factors, directly or indirectly, are used for controlled delivery of the growth factors, especially for use in tissue repair and/or regeneration. The matrices may have heparin bound there...
|
|
WO/2001/066017A1 |
A biocompatible material genus (10) serves as the foundation for multiple material composition species (S2), (S3), each adapted to a specific therapeutic indication.
|
|
WO/2001/064737A1 |
The invention concerns a purified polypeptide, called ULIP6, comprising an amino acid sequence SEQ ID NO 2, the nucleic acid coding for said polypeptide, a non-coding sequence in 3' of said encoding sequence and their use in diagnosis an...
|
|
WO/2001/064738A2 |
The invention concerns an amino acid sequence capable of facilitating penetration of a substance of interest into cells and/or cell nuclei, characterised in that it is capable of reacting in vivo with aminoglycans. Optionally said sequen...
|
|
WO/2001/060852A1 |
A protein isolated from Staphylococcus epidermidis having an approximate MW of 52 kD determined by SDS-PAGE and an N-terminal amino acid sequence (SEQ ID NO:1), and antigenic determinant-containing fragments of the protein, optionally co...
|
|
WO/2001/045669A1 |
The present invention relates to the therapeutic use of particles which are efficiently removed from the circulation, the said particles display pathogen-specific binding moieties to chaperone the clearance of potentially injurious subst...
|
|
WO/2001/046214A2 |
The present invention concerns a compound comprising a biomolecule moiety and an organo-silane moiety, as well as a process for the synthesis thereof. The invention also concerns a support comprising the biomolecule moiety with the organ...
|
|
WO/2001/046464A1 |
The present invention relates to a branched compound for use in nucleic acid detection and analysis reactions, as well as a process for the synthesis thereof. The invention also concerns a process for a nucleic acid synthesis reaction ma...
|
|
WO/2001/046213A2 |
The present invention concerns a compound comprising a biomolecule moiety and an organo-silane moiety, as well as a process for the synthesis thereof. The invention also concerns a support comprising the biomolecule moiety with the organ...
|
|
WO/2001/044302A2 |
The invention relates to a nano- to mesoscaled, two-dimensional anisotropic SAM layer (self assembling monolayer) consisting of identical molecular functional components which are provided with identical reproducible structural changes b...
|
|
WO/2001/044301A1 |
The immobilisation of single domain antigen binding fragments of antibodies naturally devoid of light chains, or protein domains functionally equivalent thereto, onto a solid surface through covalent cross-linking is described. The bindi...
|
|
WO/2001/042305A1 |
The present invention provides novel Interleukin-1 Receptor Antagonist-Like (IL-1ra-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for ...
|
|
WO/2001/042465A2 |
The present invention provides Chordin-Like (CHL) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing CHL polypeptides. The inven...
|
|
WO/2001/042304A1 |
The present invention provides novel Interleukin-1 Receptor Antagonist-Related (IL-1ra-R) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods f...
|
|
WO/2001/040310A2 |
The immobilisation of proteins at solid surfaces facilitated by incorporation of a polypeptide segment which is capable of adopting a folded structure is described. Materials comprising proteins so immobilised and uses thereof are also d...
|
|
WO/2001/038547A2 |
Described are polypeptides comprising at least two peptide monomers comprising a nuclear localization sequence or a protein transduction domain and their use for transferring molecules into eukaryotic cells, as well as pharmaceutical com...
|
|
WO/2001/036595A2 |
This invention relates to constructs for the conditional or regulated expression or excision of transgenes in plants using site-specific recombinase systems. The constructs comprise a variety of constitutive, inducible, tissue specific o...
|
|
WO/2001/032760A1 |
A porous, molecularly imprinted polymer and a process for its preparation are described. The porous, molecularly imprinted polymer is characterised in that it is obtainable by providing a porous silica; attaching a molecular template to ...
|
