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JP2022525361A |
Surfactants for use to inactivate enveloped viruses, including surfactants that are considered environmentally friendly and can be used in biomanufacturing operations. As used herein, a method of inactivating an enveloped virus in a liqu...
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JP7059709B2 |
To provide a new composition excellent in functionality such as emulsifiability and dissolubility, and to provide the composition which can be produced for a short time.There are provided a composition that contains a conjugate in which ...
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JP7059095B2 |
The present invention relates to new immunogenic compositions comprising conjugatedStreptococcus pneumoniaecapsular saccharide antigens (glycoconjugates) and uses thereof. Immunogenic compositions of the present invention will typically ...
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JP2022521730A |
The present disclosure provides labeling reagents for labeling substrates such as nucleotides, proteins, antibodies, lipids, and cells. The labeling reagents provided herein can include fluorescent labels and semi-rigid linkers. Methods ...
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JP2022050540A |
To provide alternative methods to optimize cell growth and viability by overcoming current limitations in continuous perfusion cell culture.Provided a continuous perfusion culture process, comprising: (a) monitoring pH in a cell culture ...
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JP2022518914A |
Disclose the components, systems, and methods for protein synthesis of glycoproteins in vitro and in vivo. In particular, the disclosed components, systems, and methods relate to modular platforms for producing glycoproteins. The compone...
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JP2022518626A |
Targeted nanoparticles for the diagnosis, treatment, or prevention of fungal infections are provided herein. Targeted nanoparticles (eg, liposomes) for the diagnosis, treatment, or prevention of fungal infections are provided herein. Som...
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JP7034040B2 |
To provide a compound, composition and activity measurement method for use in activity measurement of acid protease.The compound includes a structure of general formula (1), X-X-Arg-Y, having a structure to prevent cleavage caused by an ...
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JP7032383B2 |
The present disclosure relates to compounds comprising a negatively-charged polymer moiety which is capable of entering a nanopore and upon entering a nanopore in the presence of positive ions results in an increased flow of the positive...
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JP2022517122A |
The present invention relates to methods for performing solid phase peptide synthesis, automatic parallel solid phase peptide synthesis, and devices designed to perform such methods. According to the present invention, ultrasonic waves a...
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JP2022031718A |
To provide peptoid polymers capable of reducing or inhibiting the formation of ice crystals at less than 0°C, and peptoid-peptide hybrids comprising peptoid polymers.Peptoid polymers and peptoid-peptide hybrids with specific sequences a...
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JP7012533B2 |
The present invention relates in general to bacterial cells having genetic alterations that result in increased expression of a protein of interest and methods of making and using such cells. Aspects of the present invention include alte...
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JP2022513452A |
The present invention comprises the Cucumber Mosaic, which comprises at least one fusion protein. With respect to the modified virus-like particles (VLP) of Virus) (CMV), the at least one fusion protein said b) contains or preferably con...
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JP7012432B2 |
In one aspect, the present invention provides, for example, an improved method for identifying an epitope on a protein, comprising the following steps: (A) contacting a major histocompatibility complex (MHC molecule)-expressing cell diff...
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JP7011830B2 |
The present invention provides peptoid polymers capable of reducing or inhibiting the formation of ice crystals at sub 0° C. temperatures. Also provided are peptoid-peptide hybrids comprising the peptoid polymers provided herein. The pe...
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JP2022510152A |
To temporarily control protein localization, which is particularly useful for investigating and programming dynamic cellular processes, and light molecules and small molecules are the most widely used in user-defined control. Serves as t...
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JP7005601B2 |
The subject of the application is protein hydrolyzates having specific amounts of the amino acids arginine and lysine, which demonstrate improved properties in hair treatment compositions and in cleansing compositions for skin and hair, ...
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JP2022505464A |
The present invention relates to the genetic integration of 2,3-diaminopropionic acid (DAP) into a polypeptide, an unnatural amino acid containing DAP, a tRNA synthetase for charging a tRNA with an unnatural amino acid containing DAP, an...
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JP2022501028A |
The Pikia pastris alcohol dehydrogenase 2 (ADH2) promoter variant is characterized by comprising at least one of the specified modifications on the wild Pikia pastris ADH2 promoter set forth in SEQ ID NO: 1. , Nucleotides a) 647 ~ 660 (-...
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JP2022500442A |
The present disclosure generally relates to methods for making protein polymers. The method comprises utilizing oligonucleotides to control the association pathway of oligonucleotide-functionalized proteins to oligomer / polymer materials.
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JP2022000013A |
To provide a powdery formulation with high content of polyunsaturated fatty acids, which has significantly improved stability in regard to development of unpleasant odor.A coated particulate composition comprises coated particles having ...
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JP2021535108A |
The present disclosure provides powerful techniques for the development, production, characterization, and / or use of stapled peptide compositions. In particular, the present disclosure develops, produces, characterizes, and uses strate...
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JP2021534146A |
The present invention provides a peptide nucleic acid derivative that targets the 5'splice site of "exon 12" of human ACC2 pre-mRNA. The peptide nucleic acid derivative in the present invention strongly induces a splice variant of human ...
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JP2021531295A |
The present invention is a bicyclic peptide complex comprising a peptide construct, wherein the construct is (i) a polypeptide having a free end (N or C); (ii) optionally a nucleic acid encoding the polypeptide. (Iii) The linker comprise...
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JP2021529790A |
To screen pharmaceutical compositions and methods for treating and preventing conformational diseases such as TDP-43 proteopathy, SMA, amyloid-positive cancer, normal and premature aging, and therapeutic candidates for treating conformat...
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JP2021138769A |
To provide methods for purifying polypeptides such as antibodies.The invention provides a method for purifying a polypeptide from a composition comprising the polypeptide and contaminants comprising the following series of steps: (a) loa...
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JP2021524016A |
A high-throughput analysis of proteins and their application libraries, the high-throughput analysis of proteins, using a tagged semi-cloned mouse library, with one or more tagged protein antibodies for multiple different target proteins...
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JP2021120402A |
To provide a protein composition in which an ester group included in protein is removed or reduced.A protein composition contains protein and has a hydrolysis history of an ester group.SELECTED DRAWING: None
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JP2021519347A |
The present invention provides an improved method of macrocyclization of peptide mimetics, as measured by isolated yield and product distribution, which provides an amide C = O bond in one or more backbones. Includes replacement with a t...
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JPWO2019240288A1 |
The present invention provides techniques that allow antibody modification, in particular regioselective modification of the antibody. More specifically, the present invention describes the following formula (I): ALEB (I) [in the formula...
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JP6882550B2 |
The present invention relates to methods for predicting T cell epitopes. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are im...
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JP6882199B2 |
The present application relates to materials and methods for exploiting synthetic lethality and/or chemo-sensitisation in DNA damage response (DDR) pathways. In particular, the application relates to ubiquitin hydrolase protein Ubiquitin...
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JP2021080273A |
To provide materials which can have a function for preventing hair loss and/or promoting hair growth, which is the same or better as compared with that of conventional hair growth agents, and which have better physiological properties su...
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JP2021510538A |
Protein molecules corresponding to the acetylation sites of nuclear localization polypeptides, such as PD-1, PD-L1 and PD-L2, as well as those that inhibit or reduce the nuclear localization of nuclear localization polypeptides. Use is d...
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JP2021063026A |
To provide proteoglycan having an improved water-holding capacity.The present invention relates to a salmon-derived proteoglycan satisfying all of the following conditions 1)-3): 1) an intrinsic viscosity of 4.6 dL/g; 2), as elements, a ...
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JPWO2019194249A1 |
An object of the present invention is to provide a modified fibroin fiber having reduced shrinkage due to contact with moisture and a method for producing the same. The modified fibroin fiber of the present invention is a doping solution...
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JP6856828B2 |
A polar solvent solution of the present invention is a polar solvent solution in which a solute containing a polyamino acid is dissolved in a polar solvent. An inorganic salt is added to the solution, and a mole ratio of moisture to the ...
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JP2021507723A |
Disclosed herein are nucleic acid regulatory elements, expression cassettes, expression vectors, and methods of using nucleic acid regulatory elements, expression cassettes, expression vectors to treat pyramidal cell disorders.
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JP6818889B2 |
The present invention relates to a nucleic acid complex having a novel structure, which can introduce a bioactive nucleic acid into cells, a composition for treating and diagnosing disease, which comprises the same, and a method of regul...
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JP6799823B2 |
An object of the present invention is to provide a composition that serves as an efficient arginine substrate for inducible NO synthase (iNOS) in tumor. The present invention provides a polyion complex (PIC) of PEG- b -poly(L-Arg) or pol...
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JP2020189847A |
To provide highly penetrating compositions or highly penetrating prodrugs of peptides and peptide-related compounds.Provided herein is a high penetration composition or high penetration prodrug of a peptide or peptide-related compound co...
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JP2020530039A |
The polymers, methods of making polymers, and compositions are disclosed with a focus on cross-linking the heterocycle containing the portion of formula I with thiols and thiolates.
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JP2020529472A |
The present disclosure provides an efficient and reliable method for preparing cyclized peptide compounds. Preferably, the methods described herein provide cyclization on the resin using a limited number of treatment steps while increasi...
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JP6757338B2 |
The present invention relates to fusion proteins comprising a binding protein and an IL-15 polypeptide as well as uses thereof, pharmaceutical compositions comprising such fusion proteins and a method for producing such fusion proteins.
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JP2020143066A |
To provide peptide and protein-based therapeutics improved in pharmaceutical properties.There is provided a peptide product comprising a surfactant covalently attached to a peptide, the peptide comprising a linker amino acid and at least...
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JP2020527048A |
The present invention relates to a method for purifying a protein having tubulin carboxypeptidase activity from a biological extract, which comprises a polymerization / depolymerization cycle performed on the biological extract in the pr...
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JP2020525462A |
The present invention presents improvements in drug delivery and, for example, i) stapling two amino acids to form a staple CPP (StaP), or ii) stitching three or more amino acids to form a stitched CPP (StiP). With respect to the use of ...
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JP6730834B2 |
To provide a protein composition having a high β-sheet structure and a high gelation rate.According to the present invention, there is provided a protein composition comprising a GAGAGS sequence (1) and an amino acid sequence (X) descri...
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JP6730949B2 |
The present invention relates to a method for removing biopolymer aggregates and viruses from a fluid. In a first step, the biopolymer aggregates are selectively removed by filtration through a porous, polyamide-comprising shaped body ha...
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JP2020520988A |
The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as presenter proteins (eg, members of the FKBP family, members of the cyclophilin family, or PIN1) and interfaces between target pr...
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