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WO/2003/025164A2 |
The invention relates to a new strain of Pseudomonas putida (designated as HI-70) and to the isolation, cloning, and sequencing of a cyclododecanone monooxygenase-encoding gene (named cdnB) from said strain. The invention also relates to...
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WO/2003/022785A2 |
This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. A...
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WO/2003/020890A2 |
Genes have been isolated from a variety of bacteria encoding Baeyer-Villiger monooxygenase activity. The genes and their products are useful for the conversion of ketones to the corresponding esters. A series of motifs, common to all gen...
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WO/2003/016543A2 |
A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula [insert chemical structure] wherein R1 is -O-C(O)alkyl, -O-C(O)aryl or -O-C(O)cycloalkyl by contacting the mixture with a carboxylic es...
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WO/2003/012126A2 |
The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. ...
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WO/2003/010155A1 |
The invention relates to a method for producing novel spinosyn derivatives, which are substituted in the C-21 position by a 1-hydroxy-ethyl radical, to novel spinosyn derivatives of this type per se and to their use for producing novel s...
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WO/2003/010324A2 |
The invention discloses a method of preparing simvastatin or analogs or derivatives thereof, by biological expression, wherein said method comprises: a) providing a host having a customised gene encoding for a polyketide synthase; b) fer...
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WO/2003/005962A2 |
In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a furth...
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WO/2003/004701A2 |
The invention concerns a method for determining the capacity of Fusarium fungi in producing trichothecene toxins characterised in that it comprises a step which consists in detecting at least a sequence representing a specific production...
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WO/2003/002549A1 |
The invention relates to novel compounds of general formula (I), wherein R(1), R(2), R(3), R(4) independently represent hydrogen or an alkyl radical. The compounds of formula (I) are inhibitors of KDR-kinase, having an anti-angiogenetic ...
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WO/2003/002747A1 |
A method of producing a flavonoid aglycone concentrate from plant material containing a suitable flavonoid glycoside and/or conjugate thereof comprising the steps of: (i) enzymatically converting the flavonoid glycoside or conjugate ther...
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WO/2003/000910A2 |
An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a $i(Pseudomonas sp. )strain in a submerged medium at a temperature within a...
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WO/2003/000673A2 |
In this invention, preparation of SIMVASTATIN from lovastatin is described by a novel method consisting of alkylation of an $g(a)-carbon to a carboxyl group. The main feature of this invention is the protection of the carboxyl in the lac...
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WO/2003/000915A1 |
A method for producing an optically active amino acid, which comprises adding ammonia to an acrylic acid derivative by action of a plant enzyme and obtaining the corresponding optically active amino acid. The method for producing an L-am...
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WO/2003/000875A2 |
Vitamin B¿6?-phosphatase (VB6PP), a process for producing VB6PP and a process for producing vitamin B¿6? from vitamin B¿6?-phosphate (VB6P) utilizing VB6PP and a cell-free extract of a specific microorganism capable of producing VB6PP.
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WO/2002/103001A1 |
The identification of a new key enzyme in vitamin C synthesis, and its use to modulate vitamin C synthesis in eukaryotic cells are disclosed. Specifically, the isolation of a multimeric GDP-mannose-3',5'-epimerase, the identification, cl...
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WO/2002/101013A2 |
This invention relates to genes encoding key enzymes in the biosynthesis of &agr -methylene-&ggr -butyrolactone (tulipalin A). The key enzymes are glutamate decarboxylase, &ggr -aminobutyrate aminotransferase, &ggr -hydroxybutyrate dehyd...
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WO/2002/101003A2 |
The invention concerns a method for producing a cyclic L-amino acid of formula (I), characterised in that it consists in reacting a L-diamino acid of formula (II) or an enantiomeric mixture comprising such a L-diamino acid and a correspo...
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WO/2002/101052A2 |
The present invention concerns a protein comprising or consisting of: i) the amino acid sequence illustrated in Figure 8 or, ii) a fragment of the amino acid sequence illustrated in Figure 8 (SEQ. ID. N°14), said fragment having at leas...
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WO/2002/099113A1 |
Macrolide compounds having the following chemical structure, which are obtained by culturing Sorangium cellulosum, have an antifungal activity over various fungi such as those belonging to the genera Phytophthera, Absidia, Rhizopus and A...
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WO/2002/097082A2 |
The complete DNA sequence of the gene cluster encoding the polypeptides responsible for the biosynthesis of the polyene antibiotic amphotericin of S. nodosus is provided. Engineered alteration of the amphC) gene so as to eliminate produc...
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WO2001021772A9 |
The present invention features methods of producing panto-compounds e.g. , pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthe...
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WO/2002/097063A1 |
The invention provides a process of producing bio-available folate, i.e. folic acid having an increased proportion of monoglutamyl folate and a decreased proportion of polyglutamyl folate, by culturing food-grade micro-organisms containi...
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WO/2002/097062A2 |
Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyket...
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WO/2002/094185A2 |
This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including folate, galactose, galactosamine, N-acetyl galactosamine, PEG, phospholipid, peptide and human serum albumin ...
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WO/2002/095044A2 |
A method for catalyzing reactions of aryl-thiols and aryl-thioesters with water, alcohol or carboxylic acid using an enyzme or microorganism leading to the hydrolysis, esterification or trans-esterification or these compounds, which is p...
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WO/2002/092801A2 |
Disclosed is a family of P450 monooxygenases, each member of which regioselectively oxidizes avermectin to 4'-keto-avermectin. The P450 monooxgenases find use in methods and formulations for making emamectin from avermectin. Also disclos...
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WO/2002/092589A2 |
The invention relates to the isolation, structural determination, synthesis and utilization of decalactones and their derivatives as medicaments. Said novel natural substances were isolated from the culture broth of a fungus, which is pr...
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WO/2002/086138A2 |
The invention relates to a method for transforming amines of general formula (I), wherein A represents (i), into compounds of general formula (II) or (III), wherein B represents HO-CH¿2?-R?3¿- or R?4¿-. The method comprises the follow...
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WO/2002/086110A2 |
The invention relates to genetic sequences, which code for enzymes of the flavonoid metabolism, in particular for flavone synthase I (FNS I) or derivatives thereof. The invention also relates to the use of said sequences for carrying out...
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WO/2002/086139A1 |
The invention provides compounds of the Formula 1 (I); wherein the definitions of m, n, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿ R?7¿, R?8¿, R?9¿, R?10¿, R?11¿, R?12¿ and R?13¿ are in the specification. These compounds are useful ...
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WO/2002/085310A2 |
This invention relates to new antibiotics designated AA-896-A1, AA-896-A2, AA-896-A3, AA-896A4, AA-896-5, AA-896-A6, AA-896-B1, AA-896-B2, AA-896-B3, AA-896-B4, AA-896-B5, AA-896-B6, AA-896-B7, AA-896-C1, AA-896-C2, AA-896-C3, AA-896-C4,...
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WO/2002/083062A2 |
The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB wherein n is 0 or 1; R?1¿ is hydrogen or hydroxy; R?2¿ is hydrogen; or, when n is 0, R?1¿ and R?2¿ taken toge...
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WO2001053330A9 |
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hy...
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WO/2002/081440A2 |
The invention provides methods and host cells for the production of ascorbic acid intermediates. The invention also provides host cells having a modification in a polynucleotide that uncouples the catabolic pathway from the oxidative pat...
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WO/2002/080846A2 |
This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R?1�, R?2�, R?3�, R?4�, R?5�, W, X, Y, and Ar are as defined herein. Compounds of formula (I) are useful ...
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WO/2002/079465A2 |
An isolated gene cluster of Micromonospora echinospora which codes for calicheamicin biosynthesis. The biosynthetic gene cluster contains genes encoding proteins and enzymes used in the biosynthetic production of calicheamicin, including...
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WO/2002/079184A1 |
The invention relates to intermediates for producing spinosyns, to various methods of producing them, and to the use of said intermediates for producing spinosyn derivatives.
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WO/2002/077244A1 |
It is intended to provide a process for producing PF1022 substance derivatives (in particular, PF1022-220 and PF1022-260) by the direct fermentation method and a transformant to be used in this process. Thus, a transformant capable of pr...
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WO/2002/077255A1 |
The present invention relates to fluoro sugar and other sugar derivatives of indolopyrrolocarbazoles, their salts and hydrates, which exhibit selective topoisomerase I (topo I) activity, are useful in inhibiting the proliferation of tumo...
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WO/2002/077203A1 |
A process for selectively producing beauveriolide I or beauveriolide III whereby a large amount of beauveriolide I or beauveriolide III can be obtained at a high yield by culturing a beauveriolide-producing strain FO-6979 or its mutant i...
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WO/2002/077179A2 |
This invention provides detailed sequence analysis and characterization of the gene cluster responsible for the synthesis of leinamycin in Streptomyces atroolivaceus. The leinamycin gene cluster provides a hybrid polyketide synthase/nonr...
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WO/2002/077254A2 |
The invention relates to a method that is suitable for producing useful products, which are usually retained in the interior of cells, in organisms and for obtaining the products from the latter, without destroying the productive organis...
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WO/2002/074926A2 |
The invention provides methods and materials related to the production of organic products such as glucuronic acid, ascorbic acid, and glucaric acid. Specifically, the invention provides cells, methods for culturing cells, isolated nucle...
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WO/2002/074792A1 |
(Beauveria) sp. FO-6979 (FERM BP-6681), which belongs to the genus Beauveria and is capable of producing FO-6979-M0, -M1, -M2, -M3 and -M4 substances, is cultured in a medium to thereby accumulate the FO-6979-M0, -M1, -M2, -M3 and -M4 su...
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WO/2002/072858A2 |
The invention concerns a process for a degradation of an epothilone C or a epothilone D, wherein an epothilone C or epothilone D is subjected to an olefin metathesis in the presence of ethylene and subsequently an optional ester hydrolys...
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WO/2002/072089A2 |
Use of thiolutin dioxide and its derivatives in the manufacture of a medicament, and a process for the preparation thereof. The present invention relates to the use of thiolutin dioxide and its derivatives in the manufacture of a medicam...
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WO/2002/072848A2 |
The invention relates to a method for producing vitamin E by cultivating organisms, especially plants, which have an increased tyrosine aminotransferase activity in relation to the wild type. The invention also relates to the genetically...
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WO/2002/072617A1 |
A microorganism belonging to the genus Bacillus is cultured and novel thiopeptide compounds QN3323 and publicly known compounds thiocillin I/II, etc. are collected from the culture medium. Because of having a favorable antibacterial acti...
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WO/2002/070726A1 |
Treatment of a racemic lactate derivative with an enzyme having an ability to hydrolyze an ester asymmetrically causes specific hydrolysis of the ester moiety of one of the optical isomers constituting the racemic lactate derivative, and...
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