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WO/2024/084343A1 |
In one aspect, a method of operating a mass spectrometer having an ion source, at least one ion optic positioned downstream of the ion source and at least one ion mass filter positioned downstream of the ion optic is disclosed, which inc...
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WO/2024/084470A1 |
A method of imaging a biological sample is disclosed, which comprises coupling at least one affinity probe to the biological sample, wherein the affinity probe includes a cleavable tag, bringing the probe-coupled biological sample into c...
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WO/2024/086495A2 |
The described and claimed technology includes a fixture for applying and/or maintaining positive pressure in an electrode reservoir and related methods for pressurizing an electrode reservoir.
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WO/2024/086326A1 |
Methods and systems to detect an anomaly caused by unknown aerosol hazardous particles in an environment using single particle mass spectra of environmental aerosol samples. An autoencoder is trained using a dataset of single particle ma...
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WO/2024/086783A1 |
Systems and methods for analyzing samples are provided. In some embodiments, a mass spectrometer may include a source configured to output a plurality of particles, a tube having a central axis, and a skimmer. In some embodiments, the sk...
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WO/2024/079201A1 |
The invention provides a device and method for recording spectral information of charged particle beams, such as ion beams, or of light beams, at a high resolution. Specifically, a mass spectrometer having a focal plane detector is discl...
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WO/2024/031106A3 |
Systems and methods for analyzing samples are provided. In some embodiments, a mass spectrometer may include a source configured to output one or more ions, a plurality of chambers having different pressures, a detector configured to det...
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WO/2024/079261A1 |
A computer-implemented method for detecting at least one analyte in a sample with a laser desorption mass spectrometer (220) is disclosed. The method comprises: a) at least one imaging step comprising imaging at least one reflective targ...
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WO/2024/080963A1 |
The present disclosure is directed to an ion funnel and associated systems, where the ion funnel includes a plurality of electrodes each define an opening having an associated inner dimension and receive a RF voltage. The associated inne...
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WO/2024/074173A1 |
The invention relates to the provision of a suitable interior for a near-atmospheric-pressure operating mode and a vacuum-pressure operating mode of an entrance portion of a material analysis system. The entrance portion comprises a hous...
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WO/2024/074492A1 |
The invention relates to a method for metabolomic profiling of a holobion using Liquid Chromatography-Mass Spectrometry.
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WO/2024/076552A1 |
The invention generally relates to systems and methods for combined spectroscopy systems. In certain embodiments, laser-induced breakdown spectroscopy (LIBS) and Raman spectroscopy can be combined in a single, handheld device using a sin...
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WO/2024/069125A1 |
A rod support for a multipole rod assembly of a mass spectrometer, the rod support comprising a body with an opening extending along a predetermined axis through the body, and two or more rods, which are unitarily formed with the body an...
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WO/2024/072802A1 |
Described herein are methods and systems for characterizing one or more conditions of a subject based on analysis of biological samples obtained from the subject by mass spectrometry.
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WO/2024/064829A1 |
Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a method is provided that includes receiving a first plurality of e...
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WO/2024/038241A9 |
An aerosolisation system (10) is provided for producing at least one aerosol plume (78) of, optionally charged, droplets (80). The aerosolisation system (10) has a nebuliser (14a), electrically-energisable vibration means (36), and AC co...
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WO/2024/056121A1 |
The invention relates to a method and a device for monitoring and controlling the performance of an ion source, said method comprising: (a) using a laser to ionise a control sample, the composition of which is substantially known and whi...
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WO/2024/057238A1 |
The presently claims and described technology provides methods and kits for quantifying at least one analyte in a sample by mass analysis using a labeled isotopologues as an internal standards and to generate internal calibration curves.
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WO/2024/054539A1 |
Methods leverage premixed gas mixtures to perform a metrology process on a substrate using an inline secondary ion mass spectrometry (SIMS) process. The premixed gas mixture of two or more gases is injected into a plasma chamber that is ...
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WO/2024/054960A1 |
A method is provided for controlling a multi-pole charged particle transmission device having rods spaced apart radially about a central axis extending from a particle inlet at one end of the device to a particle outlet at an opposite en...
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WO/2024/054382A1 |
The invention generally relates to methods for employing mass spectrometry techniques to sequence and analyze biological molecules, such as glycan. In certain aspects, the invention provides methods for sequencing a biological molecule t...
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WO/2024/047723A1 |
Provided is a new ion source that produces microdroplets from a liquid sample continuously supplied from a liquid chromatograph or the like, electrically charges the microdroplets, executes a series of treatments for vaporizing a solvent...
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WO/2024/050445A1 |
An optical arrangement splits an optical beam into multiple beamlets and focuses each beamlet at a respective line. Each line is defined with reference to a respective spatially-separated location across at least one dimension, such that...
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WO/2024/044840A1 |
An inductively coupled plasma (ICP) torch includes: an injector defining an injector flow passage to receive a flow of a sample fluid; a plurality of tubes disposed about the injector and configured to receive and direct a flow of one or...
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WO/2024/049967A2 |
A method and an apparatus utilizing targeted ion mobility spectrometry for the detection of the SARS-CoV-2 virus and its variants, by measuring the quantity of free polyamines including putrescine, spermidine, and spermine in a sublingua...
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WO/2024/050379A1 |
A system for identifying and predicting the presence of non-alcoholic fatty liver disease (NAFLD). The system can receive historical biological data associated with multiple individuals. The historical biological data can include biologi...
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WO/2024/047371A1 |
Coupled CE-MS apparatus with improved precision, the apparatus comprising a device for performing capillary electrophoresis of a sample,said device having a separation capillary and a mass spectrometer and a flow reactor arranged in the ...
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WO/2024/050446A1 |
An electrostatic ion trap or an array of electrostatic ion traps are provided having a longitudinal length of no more than 10 mm and/or at least one electrode with a capacitance to ground of no more than 1 pF. First and second sets of pl...
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WO/2024/042908A1 |
In order to achieve an ion guide wherein the m/z range of ions that can pass through the ion guide is large, and the structure is simple and resistant to contamination, the present application proposes (see fig. 2A) an ion guide that has...
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WO/2024/041681A1 |
The invention relates to a device for multimodal analysis of sample material, e.g. from a tissue, which acquires molecule image data from the sample material in a spatially resolved fashion, e.g. using MALDI time-of-flight mass analyzer,...
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WO/2024/039633A1 |
A method for Charge Detection Mass Spectrometry (CDMS) with improved accuracy with reduced computation requirements. An apodization-specific peak fitting function is used to determine peak amplitudes and frequencies in the Fourier transf...
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WO/2024/035893A1 |
A system includes a sample chamber, an aperture plate defining an aperture having an aperture axis aligned with a sample location within the sample chamber. The system further includes a first laser source to produce a cloud of material ...
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WO/2024/028579A1 |
An electrospray device (8) comprising: a first end (9) for fitting as a cap in, or over, an opening (5) of a tube (2); a second end (10) for electrospraying a liquid sample therefrom; a bore (11) having an entrance opening in the first e...
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WO/2024/030126A1 |
An apparatus includes a plurality of electrodes arranged in a sequence along a propagation axis between an ion inlet and an ion outlet to define an ion path and volume, wherein the electrodes are configured to receive respective voltages...
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WO/2024/023317A1 |
The present disclosure relates to methods of detecting metabolites using a microfluidic capillary electrophoresis-mass spectrometry (CE-MS) system. The metabolites can be useful to diagnosis diseases or disorders, as well as to monitor t...
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WO/2024/025517A1 |
A method for detecting particles in a gas of a process environment present in a process chamber, the method comprising the steps of : guiding the gas with the particles into an ionization and charging unit (11) being in fluid communicati...
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WO/2024/024194A1 |
A sample plate holder (6) for a mass spectrometry device comprises: urging members (631 to 633) for pushing one surface of a sample plate toward another surface thereof at three locations that are not positioned on a straight line; and a...
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WO/2024/025662A1 |
In some examples, an ion funnel-based collision cell may include an ion funnel entrance section formed by a plurality of adjacently disposed entrance members. Each entrance member of at least one pair of the adjacently disposed entrance ...
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WO/2024/025661A1 |
In some examples, a multipole section-based ion funnel may include an ion funnel section formed by at least one pair of adjacently disposed members. A first member of the at least one pair of adjacently disposed members may include a pol...
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WO/2024/023525A1 |
A charge detection mass spectrometry (CDMS) device comprising: an ion trap for receiving an ion flux and configured for selectively trapping and analysing one or more ions of interest from the ion flux, and at least one primary charge de...
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WO/2024/016074A1 |
A nebulizer includes a gas transport conduit having a gas inlet for receiving a nebulizer gas and an outlet, the gas transport conduit defining a longitudinal axis along flow direction of the nebulizer gas; and an analyte supply conduit ...
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WO/2024/017606A1 |
Residual gas analyser, especially for analysing a residual gas in a microlithography projection exposure apparatus, comprising a mass spectrometer (27) and an admission device (28, 29, 24) for admitting constituents of the residual gas f...
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WO/2024/018275A1 |
A method for adaptive secondary ion mass spectroscopy, the method may include (a) adaptively setting a detection parameter that impacts an instantaneous count rate of a detector; (b) scanning an evaluated sample with a focused primary io...
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WO/2024/015784A1 |
The present invention relates to corona charge deposition systems that use High Voltage (HV) amplifiers for precisely controlling corona charge deposition. Some implementations, provide a corona charge deposition system that uses multipl...
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WO/2024/013650A1 |
The invention provides a sample delivery system for an analytical instrument, comprising: a valve assembly comprising one or more valves, the valve assembly configured to receive an external sample from a sample source; an external sampl...
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WO/2024/014208A1 |
The present invention provides an ion guide and a mass spectrometer that achieve both high ion intake efficiency and high ion convergence efficiency. Provided is an ion guide wherein ions advance through an internal space from an inlet...
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WO/2024/011187A1 |
Curved ion manipulation devices can provide relatively greater ion pathway lengths over conventional devices. Ions can be directed through one or more pairs of opposing curved surfaces of a curved ion manipulation structure. Each pair of...
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WO/2024/009184A1 |
A method for mass spectrometric analysis of a peptide having at least one fragile moiety includes using electrospray ionization to generate a negatively charged ion of said peptide, trapping and cooling the negatively charged peptide ion...
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WO/2024/004311A1 |
Provided are a measurement device and a mass spectrometer that allow estimating the range of an abnormal portion that is a source of noise superimposed on a detection signal. In order to achieve the above purpose, a measurement device ...
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WO/2024/006608A1 |
What is disclosed herein are quadrupole mass filters (QMF) and related methods. The QMFs may have a relatively high surface roughness and/or be additively manufactured, wherein the QMF may be configured for ion filtering in a mass spectr...
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