Title:
【発明の名称】金属タンパク質分解酵素阻害剤
Document Type and Number:
Japanese Patent JP2001509790
Kind Code:
A
Abstract:
Compounds of formula (I) wherein R2 is a group -(Alk)m-(Q)n-(Alk<1>)p-Ar wherein m, n and p are independently 0 or 1, Alk and Alk<1> each independently represents a divalent (C1-C3)alkylene group, Q represents -O-, -S-, -SO-, or -SO2-, and Ar represents an optionally substituted phenyl or heteroaryl group; R1 is hydrogen or acyl; R21 is a group -(CH2)t-W wherein t represents 1, 2, 3 or 4 and W represents a 5- or 6-membered N-heterocyclic ring as defined in the specification; Z is either (a) a saturated 5- to 8-membered monocyclic or bridged N-heterocyclic ring as defined in the specification, or (b) a radical of formula (IB) wherein R3 is the side chain of a natural or non-natural alpha -amino acid in which any functional groups may be protected; R4 is one of a variety of groups defined in the specification; and R5 is hydrogen or a (C1-C6)alkyl group. The compounds are matrix metalloproteinase inhibitors.
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Inventors:
Floyd Christopher David
Application Number:
JP52443398A
Publication Date:
July 24, 2001
Filing Date:
November 27, 1997
Export Citation:
Assignee:
British Biotech Pharmaceuticals Limited
International Classes:
C12N9/99; A61K31/4453; A61K31/454; A61K38/00; A61K38/55; A61P19/00; A61P43/00; C07D209/48; C07D401/12; C07K5/06; C07K5/065; (IPC1-7): C07D209/48; A61K31/4453; A61K31/454; A61K38/00; A61K38/55; A61P19/00; A61P43/00; C07D401/12; C07K5/06; C12N9/99
Attorney, Agent or Firm:
Shintaro Nogawa