Title:
【発明の名称】等方的に拡大された大きさを有する治療的ヘモグロビン組成物
Document Type and Number:
Japanese Patent JP2001510202
Kind Code:
A
Abstract:
Novel polysaccharide compounds are disclosed for decorating biomolecular surfaces to increase isotropic size and mask antigenicity. The oligosaccharides may be synthesized as repeating disaccharide units, or may be derived by acid hydrolysis of naturally occurring polysaccharides. Such natural sources include chondroitins obtained from shark cartilage, or hyaluronic acid. The polyanionic sulfate groups contained in the sugar moieties impart negative charges which repel the molecules from the negatively charged wall of capillaries, to lengthen retention times of decorated drug molecules, such as crosslinked hemoglobin, in the peripheral circulation.
Inventors:
Hi, Ton That
Pereira, David E.
Nelson, Dina Jay.
Pereira, David E.
Nelson, Dina Jay.
Application Number:
JP2000502782A
Publication Date:
July 31, 2001
Filing Date:
June 22, 1998
Export Citation:
Assignee:
BAXTER INTERNATIONAL INCORP0RATED
International Classes:
A61K38/16; A61P7/00; A61P43/00; C07G3/00; C07K14/805; C08B37/00; C08G63/48; A61K38/00; (IPC1-7): C08B37/00; A61K38/16; A61P7/00; A61P43/00; C07G3/00; C08G63/48
Attorney, Agent or Firm:
Shusaku Yamamoto