Title:
【発明の名称】選択的COX-2阻害剤としての置換イミダゾ[1,2a]アジン類
Document Type and Number:
Japanese Patent JP2002522438
Kind Code:
A
Abstract:
The invention refers to new compounds of formula (I), wherein A and B are selected from the group consisting of N and CH, with the condition that when A is N, B is N; R<1> is selected from the group consisting of CH3 and NH2; R<2> and R<3> are selected from the group consisting of H, CH3, Br, Cl, COCH3 and OCH3; and R<4>, R<5> and R<6>, are selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkyl, trifluoromethyl, (C1-C3)-alkoxy and trifluoromethoxy. Compounds of formula (I) are prepared by reaction of a substituted aminoazine with a substituted 2-bromo-2-(4-R<1>-sulfonylphenyl)-1-phenylethanone in a polar solvent. These new compounds inhibit COX-2 with high selectivity over COX-1. They are useful for the treatment of inflamation and/or cyclooxygenase-mediated diseases, having the additional advantage of a reduced potencial for ulcerogenic effects.
Inventors:
Carles Farrelons Galljemi
Ignacio-Jose Miquel Bono
Ana Maria Fernandez Serato
Carlos Monserrat Vidal
Carmen Ragnas Arnal
Ferran Jimenez Guash
Andres Fernandez Garcia
Ignacio-Jose Miquel Bono
Ana Maria Fernandez Serato
Carlos Monserrat Vidal
Carmen Ragnas Arnal
Ferran Jimenez Guash
Andres Fernandez Garcia
Application Number:
JP2000563657A
Publication Date:
July 23, 2002
Filing Date:
July 23, 1999
Export Citation:
Assignee:
LABORATORIOS S.A.L.V.A.T., S.A.
International Classes:
A61K31/437; A61K31/519; A61K31/53; A61P19/02; A61P29/00; A61P35/00; A61P43/00; C07D471/04; C07D487/04; (IPC1-7): C07D487/04; A61K31/437; A61K31/519; A61K31/53; A61P29/00; A61P35/00; A61P43/00; C07D471/04
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)