Title:
【発明の名称】組換えニューキャッスル病ウイルスRNAの発現系およびワクチン
Document Type and Number:
Japanese Patent JP2003512009
Kind Code:
A
Abstract:
This invention relates to genetically engineered Newcastle disease viruses and viral vectors which express heterologous genes or mutated Newcastle disease viral genes or a combination of viral genes derived from different strains of Newcastle disease virus. The invention relates to the construction and use of recombinant negative strand NDV viral RNA templates which may be used with viral RNA-directed RNA polymerase to express heterologous gene products in appropriate host cells and/or to rescue the heterologous gene in virus particles. In a specific embodiment of the invention, the heterologous gene product is a peptide or protein derived from the genome of a human immunodeficiency virus. The RNA templates of the present invention may be prepared by transcription of appropriate DNA sequences using any DNA-directed RNA polymerase such as bacteriophage T7, T3, SP6 polymerase, or eukaryotic polymerase I.
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Inventors:
Garcia-Sustre, Adolfo
Palace, peter
Palace, peter
Application Number:
JP2000570380A
Publication Date:
April 02, 2003
Filing Date:
September 14, 1999
Export Citation:
Assignee:
Mount Sinai School of Medicine of the City University of New York
International Classes:
C12N15/09; A61K39/00; A61K39/12; A61K39/145; A61K39/17; A61K39/175; A61K39/205; A61K39/21; A61K39/215; A61K39/23; A61K39/255; A61K39/285; A61P31/12; A61P31/16; C07K14/125; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12N7/01; C12N7/02; A61K48/00; (IPC1-7): C12N15/09; A61K39/00; A61K39/12; A61K39/145; A61K39/17; A61K39/175; A61K39/205; A61K39/21; A61K39/215; A61K39/23; A61K39/255; A61K39/285; A61P31/12; A61P31/16; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/00; C12N7/02
Domestic Patent References:
| JP2002517230A | 2002-06-18 | |||
| JPH08168381A | 1996-07-02 | |||
| JP2002518012A | 2002-06-25 |
Foreign References:
| US5789229A | 1998-08-04 |
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)