Title:
【発明の名称】癌および血管新生に基づく疾患の治療のための、血液凝固/凝血経路の成分を結合するリガンドの組成物および使用方法
Document Type and Number:
Japanese Patent JP2003527330
Kind Code:
A
Abstract:
Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise naturally occurring, or synthetic proteins, peptides, or protein fragments capable of binding to components of the blood coagulation pathway. The compositions may be administered using a pharmaceutically acceptable carrier. The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized metastasized tumors is useful for preventing the growth or expansion of such tumors.
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Inventors:
Green, Sean Jay.
Papa's Anasiu, Adonia E.
Papa's Anasiu, Adonia E.
Application Number:
JP2001530100A
Publication Date:
September 16, 2003
Filing Date:
October 13, 2000
Export Citation:
Assignee:
Entremed Incorporated
International Classes:
A61K38/00; A61K38/43; A61K38/48; A61K38/57; A61P1/00; A61P1/04; A61P7/00; A61P9/00; A61P9/08; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P27/02; A61P31/04; A61P35/00; A61P35/02; A61P35/04; A61K45/00; A61P43/00; C07K14/81; (IPC1-7): A61K45/00; A61K38/00; A61K38/43; A61P1/00; A61P1/04; A61P7/00; A61P9/00; A61P9/08; A61P15/00; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P27/02; A61P31/04; A61P35/00; A61P35/02; A61P35/04; A61P43/00
Attorney, Agent or Firm:
Tsutomu Toyama (4 others)