Title:
【発明の名称】複素環式ナトリウム/プロトン交換阻害薬および方法
Document Type and Number:
Japanese Patent JP2003527331
Kind Code:
A
Abstract:
Heterocyclic are provided which are sodium/proton exchange (NHE) inhibitors which have the structure wherein n is 1 to 5; X is N or C-R5 wherein R5 is H, halo, alkenyl, alkynyl, alkoxy, alkyl, aryl or heteroaryl; Z is a heteroaryl gorup, R1, R2, R3 and R4 are as defined herein, and where X is N. R1 is preferably aryl or heteroaryl, and are useful as antianginal and cardioprotective agents. In addition, a method is provided for preventing or treating angina pectoris, cardiac dysfunction, myocardial necrosis, and arrhythmia employing the above heterocyclic derivatives.
Inventors:
Salem Ahmad
Shun Shi Woo
Stephen Buoy O'Neill
Kahyun Nugu
Carnail S. Atoile
David S. Weinstein
Shun Shi Woo
Stephen Buoy O'Neill
Kahyun Nugu
Carnail S. Atoile
David S. Weinstein
Application Number:
JP2001530325A
Publication Date:
September 16, 2003
Filing Date:
October 02, 2000
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/41; A61K31/415; A61K31/4164; A61K31/4168; A61K31/4172; A61K31/4178; A61K31/4196; A61K31/4245; A61K31/426; A61K31/427; A61K31/437; A61K31/4427; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4745; A61K31/501; A61K31/505; A61K31/506; A61K31/513; A61K31/519; A61K31/5377; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P13/12; A61P19/10; A61P25/28; A61P29/00; A61P43/00; C07D231/38; C07D233/54; C07D233/84; C07D233/88; C07D239/48; C07D277/20; C07D277/40; C07D401/04; C07D401/14; C07D403/04; C07D403/06; C07D403/08; C07D403/10; C07D405/08; C07D405/14; C07D409/04; C07D409/14; C07D413/08; C07D417/04; C07D417/08; C07D233/64; C07D417/14; C07D471/02; C07D471/04; C07D487/04; C07D495/04; C07D513/04; (IPC1-7): C07D231/38; A61K31/41; A61K31/415; A61K31/4164; A61K31/4168; A61K31/4178; A61K31/4196; A61K31/4245; A61K31/426; A61K31/427; A61K31/437; A61K31/4439; A61K31/454; A61K31/4545; A61K31/501; A61K31/505; A61K31/506; A61K31/519; A61K31/5377; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P13/12; A61P19/10; A61P25/28; A61P29/00; A61P43/00; C07D233/64; C07D233/84; C07D233/88; C07D239/48; C07D277/40; C07D401/04; C07D401/14; C07D403/04; C07D403/06; C07D403/08; C07D403/10; C07D405/08; C07D405/14; C07D409/04; C07D409/14; C07D413/08; C07D417/04; C07D417/08; C07D417/14; C07D471/04; C07D487/04; C07D495/04; C07D513/04
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)
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