Title:
【発明の名称】フェノキシプロパノールアミン類、それらの製造および治療的使用
Document Type and Number:
Japanese Patent JP2003528046
Kind Code:
A
Abstract:
The invention concerns phenoxypropanolamines of formula (I)in which R1 represents a hydrogen, a group -S(O)z-(C1-C4)alk-R', (R' being H, phenyl or (C1-C4)alkoxy), -NHSO2-(C1-C4)alk or NHCO(C1-C4)alk; m and n are each independently 0, 1 or 2; R2 and R3 independently represent a hydrogen, a (C5-C6)alkyl, (C3-C6)cycloalkyl, (C1-C4)alkoxy, hydrogen(C1-C4)alkoxy-(C1-C4)alkyl, mono- or di(C1-C4)alkamino(C1-C4)alkyl, pyrrolidino(C1-C4)alkyl, phenylamino or (C2-C4)alkenyl group, an aromatic or heteroaromatic group optionally substituted with a group R4, an aralkyl or heteroaralkyl group optionally substituted with a group R4, R2 and R3 can also together constitute a saturated or unsaturated ring of 3 to 8 atoms possibly bearing a (C1-C4)alkyl, amino (C1-C4)alkyl, carbamoyl or benzyl substituent; R4 represents a hydrogen or a halogen, or a group -CO(C1-C4)alk or a group -NHSO2-(C1-C4)alk; a group (C1-C4)alk, a group (C1-C4)alkoxy, a halogen, -COOH, -COO(C1-C4)alk, -CN, -CONR3R4, -NO2, -SO2NH2 or -NHSO2(C1-C4)alk; z is 1 or 2; and the salts or solvates thereof. The compounds have agonist activity toward beta-3 adrenergic receptors.
Inventors:
Bovi, philip, earl
Setch, Robert
Ovenier, Venier
Setch, Robert
Ovenier, Venier
Application Number:
JP2001544717A
Publication Date:
September 24, 2003
Filing Date:
December 15, 2000
Export Citation:
Assignee:
SANOFI-SYNTHELABO
International Classes:
A61K31/4545; A61K31/5377; A61P1/00; A61P3/04; A61P3/10; A61P15/00; A61P17/02; A61P25/00; A61P25/18; A61P25/24; A61P27/06; C07D401/04; C07D401/14; (IPC1-7): C07D401/04; A61K31/4545; A61K31/5377; A61P1/00; A61P3/04; A61P3/10; A61P15/00; A61P25/18; A61P25/24; A61P27/06
Attorney, Agent or Firm:
Shintaro Nogawa