切断型CD200

Japanese Patent JP2004513660

A

A truncated form of the full-length, immunosuppression-inducing molecule, CD200, CD200_tr, was expressed in CHO cells and the transduced cells used to produce mAbs to CD200_tr. These mAbs detect simultaneous expression of full-length CD200 and CD200_tr in LPS-stimulated dendritic cells (DCs). Moreover, CHO cells and DCs expressing CD200_tr as well as soluble CD200_tr are able to inhibit suppression of mixed leucocyte reactions in vitro which follows addition of the soluble form of CD200 (CD200:Fc) in culture, demonstrating that CD200_tr is a physiological antagonist of CD200.

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Golzinsky Reginald M.

JP2002544465A

May 13, 2004

November 22, 2001

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Trillium Therapeutics Incorporated

G01N33/50; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P1/04; A61P1/16; A61P3/10; A61P5/40; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/04; A61P15/06; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P31/00; A61P35/00; A61P37/00; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07K14/47; C07K14/705; C07K16/18; C12N15/09; G01N33/15; (IPC1-7): C12N15/09; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P1/04; A61P1/16; A61P3/10; A61P5/40; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P15/04; A61P15/06; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07K14/47; C07K16/18; G01N33/15; G01N33/50

Hatsushi Shimizu
Kazunori Hashimoto

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