Title:
NK-3およびNK-2アンタゴニストとしてのキノリン誘導体
Document Type and Number:
Japanese Patent JP2004517062
Kind Code:
A
Abstract:
Certain compounds of formula (I) below or a pharmaceutically acceptable salt or hydrate thereof: wherein: R1 is H or alkyl; R2 is aryl, cycloalkyl or heteroaryl; R3 is H or C1-3 alkyl, optionally substituted by one or more fluorines; R4 is H, R8NR9R10, R11R13 or R11R12R13; or R5 is branched or linear alkyl, cycloalkyl, aryl, arylalkyl, or a single or fused ring aromatic heterocyclic group; a process for preparing such compounds, a pharmaceutical composition comprising such compounds and the use of such compounds and the use of such compounds and composition in medicine.
Inventors:
Carlo Farina
Stefania Galliardi
Giuseppe Giardina
Mario gruni
Marisa Martinelli
Guy Marguerite Marie Gerard Nadre
Stefania Galliardi
Giuseppe Giardina
Mario gruni
Marisa Martinelli
Guy Marguerite Marie Gerard Nadre
Application Number:
JP2002541083A
Publication Date:
June 10, 2004
Filing Date:
November 12, 2001
Export Citation:
Assignee:
GlaxoSmithKline S.p.A.
International Classes:
A61K31/496; A61K31/497; A61P1/00; A61P7/04; A61P7/10; A61P9/12; A61P11/00; A61P13/00; A61P17/00; A61P25/00; A61P25/02; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P27/02; A61P29/00; A61P37/02; A61P37/08; A61P43/00; C07D215/52; C07D401/12; (IPC1-7): C07D215/52; A61K31/496; A61K31/497; A61P1/00; A61P7/04; A61P7/10; A61P9/12; A61P11/00; A61P13/00; A61P17/00; A61P25/00; A61P25/02; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P27/02; A61P29/00; A61P37/02; A61P37/08; A61P43/00; C07D401/12
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita