Title:
ヒトRRP配列及び使用方法
Document Type and Number:
Japanese Patent JP2004519209
Kind Code:
A
Abstract:
Rhomboid Related Proteins (RRPs), involved in the EGFR signaling pathway, are provided. Transgenic, nonhuman mammals containing a transgene encoding an RRP polypeptide or a gene effecting the expression of an RRP polypeptide, along with methods of modulating the interaction of RRP proteins with their pathway members, and methods of screening for agents that modulate the interaction of an RRP polypeptide with an RRP binding target, such as RRP-specific antibodies and small molecules identified in high throughput screens, are also provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein.
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Inventors:
Friedman, Lori
Larson, Jeffrey, S.
Belvin, Masha
Chen, Chang Yu
Robertson, Stephanie, A.
Liubin, Mario
Shy, wen
Chan, Joselin
Lee, Danshi
Larson, Jeffrey, S.
Belvin, Masha
Chen, Chang Yu
Robertson, Stephanie, A.
Liubin, Mario
Shy, wen
Chan, Joselin
Lee, Danshi
Application Number:
JP2002511775A
Publication Date:
July 02, 2004
Filing Date:
July 18, 2001
Export Citation:
Assignee:
Excelix Incorporated
International Classes:
C12N15/09; A61K39/395; A61K45/00; A61K48/00; A61P35/00; C07K14/47; C07K14/705; C12N1/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; A61K38/00; (IPC1-7): C12N15/09; A61K39/395; A61K45/00; A61K48/00; A61P35/00; C07K14/47; C12N1/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori