Title:
インスリン様成長因子I受容体に対する抗体
Document Type and Number:
Japanese Patent JP2004531217
Kind Code:
A
Abstract:
The present invention relates to antibodies and antigen-binding protions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such momlecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
Inventors:
Cohen Bruce Dee.
Babe Gene
Mirror penelope E.
Moyer James Dee.
Corbalan Jose Earl.
Gallo michael
Babe Gene
Mirror penelope E.
Moyer James Dee.
Corbalan Jose Earl.
Gallo michael
Application Number:
JP2002555118A
Publication Date:
October 14, 2004
Filing Date:
December 20, 2001
Export Citation:
Assignee:
Pfizer Inc.
Abgenics Inc.
Abgenics Inc.
International Classes:
A61K39/395; A61K45/00; A61K48/00; A61K49/00; A61P35/00; C07K14/72; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/06; C12N5/10; C12N15/09; A01K67/027; C12N15/13; C12P21/08; G01N33/574; G01N33/577; G01N33/68; (IPC1-7): C12N15/09; A01K67/027; A61K39/395; A61K45/00; A61K48/00; A61K49/00; A61P35/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Kazunori Hashimoto