Title:
増殖性および分化性疾患の治療に有用な化合物の同定方法
Document Type and Number:
Japanese Patent JP2004531218
Kind Code:
A
Abstract:
The present invention relates to the discovery, identification and characterization of nucleotides that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19, FBP20, FBP21, FBP22, FBP23, FBP24, and FBP25, transgenic mice, knock-out mice, host cell expression systems and proteins encoded by the nucleotides of the present invention. The present invention relates to screening assays that use the novel substrate-targeting subunits to identify potential therapeutic agents such as small molecules, compounds or derivatives and analogues of the novel ubiquitin ligases which modulate activity of the novel ubiquitin ligases for the treatment of proliferative and differentiative disorders, such as cancer, major opportunistic infections, immune disorders, certain cardiovascular diseases, and inflammatory disorders. The invention further encompasses therapeutic protocols and pharmaceutical compositions designed to target ubiquitin ligases and their substrates for the treatment of proliferative disorders.
Inventors:
Michelle Pagano
Application Number:
JP2002556716A
Publication Date:
October 14, 2004
Filing Date:
January 07, 2002
Export Citation:
Assignee:
New York University
International Classes:
C12N9/00; C12N15/09; C12Q1/00; C12Q1/02; C12Q1/25; C12Q1/34; G01N33/50; C12Q1/37; C12Q1/68; G01N33/15; G01N33/574; (IPC1-7): C12Q1/02; C12Q1/25; C12Q1/34; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Ishii Teiji
Satoshi Fujita
Ishii Teiji