Title:
置換複素環式化合物および使用方法
Document Type and Number:
Japanese Patent JP2005530810
Kind Code:
A
Abstract:
The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R1 is additionally substituted; and R2 is a substituted C1-6alkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic beta cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
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Inventors:
Dominguez, Ceria
Jiang, Dway
Tuao, Kuo-Chiyang
Goldberg, Martin H
Hong, Juan-Tsao
Shillam, Kelvin Kay C
Taddetsu, Safe
Tamayo, Nuria A
Wyler, Kurt Yee
Riao Hongyu
Jiang, Dway
Tuao, Kuo-Chiyang
Goldberg, Martin H
Hong, Juan-Tsao
Shillam, Kelvin Kay C
Taddetsu, Safe
Tamayo, Nuria A
Wyler, Kurt Yee
Riao Hongyu
Application Number:
JP2004507465A
Publication Date:
October 13, 2005
Filing Date:
May 13, 2003
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
A61K31/444; A61K31/4545; A61K31/501; A61K31/506; A61P1/04; A61P1/18; A61P3/10; A61P9/10; A61P11/00; A61P11/02; A61P17/04; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P21/00; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P33/06; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P39/02; C07D401/04; C07D401/14; (IPC1-7): C07D401/04; A61K31/444; A61K31/4545; A61K31/501; A61K31/506; A61P1/04; A61P1/18; A61P3/10; A61P9/10; A61P11/00; A61P11/02; A61P17/04; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P21/00; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P33/06; A61P35/02; A61P37/06; A61P37/08; A61P39/02; C07D401/14
Domestic Patent References:
| JP2002514196A | 2002-05-14 | |||
| JP2002514195A | 2002-05-14 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura