Title:
テトラヒドロピラニルシクロペンチルテトラヒドロイソキノリン系のケモカイン受容体活性調節剤
Document Type and Number:
Japanese Patent JP2005532308
Kind Code:
A
Abstract:
The present invention is directed to compounds of the formula I: I(wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2
Inventors:
Ziao, Lichyard
Goblet, Stephen Day
Mills, Thunder Gi
Moriero, gregory
Pastel Nak, Alexander
Yan, riff
Chiyo
Buttra, gerber
Kosanda Raman, Siyan Karan
Guia Dane, Deodori Arsine
Moist, christopher
Goblet, Stephen Day
Mills, Thunder Gi
Moriero, gregory
Pastel Nak, Alexander
Yan, riff
Chiyo
Buttra, gerber
Kosanda Raman, Siyan Karan
Guia Dane, Deodori Arsine
Moist, christopher
Application Number:
JP2004501370A
Publication Date:
October 27, 2005
Filing Date:
April 25, 2003
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D217/04; A61K31/472; A61K31/4725; A61P1/04; A61P3/10; A61P11/00; A61P11/06; A61P13/12; A61P21/04; A61P29/00; A61P33/10; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D217/06; C07D401/12; C07D405/12; C07D405/14; C07D409/12; C07D491/04; C07D491/052; C07D493/08; C07D521/00; (IPC1-7): C07D217/04; A61K31/472; A61K31/4725; A61P1/04; A61P3/10; A61P11/00; A61P11/06; A61P13/12; A61P21/04; A61P29/00; A61P33/10; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07D401/12; C07D405/12; C07D405/14; C07D409/12; C07D491/052; C07D493/08
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura