Title:
脳の健康に効果のあるインスリン関連ペプチド
Document Type and Number:
Japanese Patent JP2005532309
Kind Code:
A
Abstract:
The present invention provides compositions and methods for ameliorating neurological, attention, or memory disorders and improving learning and cognition through the delivery of insulin A-chain and analogs thereof to a subject. Insulin A-chain, peptides comprising the 21 amino acid sequence GIVEQ CCASV CSLYQ LENYC N (SEQ ID NO:1), and functional analogs thereof are disclosed to modulate neurological activity when administered to a subject. The methods of the invention can be used to prevent or treat neurological disorders as well as improve memory retention and acquisition. The invention includes pharmaceutical compositions comprising a therapeutically or prophylactically effective amount of insulin A-chain peptide or a functional analogs thereof.
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Inventors:
Düring Matthew
Hale Colin N
Hale Colin N
Application Number:
JP2004501438A
Publication Date:
October 27, 2005
Filing Date:
May 06, 2003
Export Citation:
Assignee:
Thomas Jefferson University
International Classes:
A61K38/00; A61K38/17; A61K38/28; A61P25/00; A61P25/28; A61P43/00; A61K47/40; C07K14/62; C07K14/705; (IPC1-7): A61K38/00; A61K47/40; A61P25/00; A61P25/28; A61P43/00
Foreign References:
| WO2000061177A1 | 2000-10-19 | |||
| US5725860A | 1998-03-10 |
Attorney, Agent or Firm:
Hiroaki Tazawa
Konobu Kato
Hideaki Tazawa
Hamada Hatsune
Konobu Kato
Hideaki Tazawa
Hamada Hatsune
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