Title:
スルホトランスフェラーゼの神経変性疾患に関する診断的および治療的使用
Document Type and Number:
Japanese Patent JP2007508810
Kind Code:
A
Abstract:
The present invention discloses the differential expression of a cytosolic sulfotransferase in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a gene coding for SULT4A1. A method of screening for modulating agents of neurodegenerative diseases and recombinant animal models are also, disclosed.
More Like This:
Inventors:
Von der Kammer Heinz
Paulner Yoharness
Paulner Yoharness
Application Number:
JP2006530259A
Publication Date:
April 12, 2007
Filing Date:
September 29, 2004
Export Citation:
Assignee:
Evotech Neuroscience Gesell Shaft Mitt Beschlenktel Haftung
International Classes:
C12Q1/02; A01K67/027; A01K67/033; A61K45/00; A61K48/00; A61P21/04; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; C12N9/10; C12N15/85; C12Q1/48; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/68; C12N15/09
Foreign References:
| WO2002018541A2 | 2002-03-07 | |||
| WO2000014251A2 | 2000-03-16 | |||
| WO1997021807A1 | 1997-06-19 |
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes