Title:
PTHアゴニスト
Document Type and Number:
Japanese Patent JP2007522214
Kind Code:
A
Abstract:
This invention relates to compounds of formula (I) wherein A is S, O, N, or CH; B is S, O, N, or CH; R1 and R2 are the same or are different and are C1-8 alkyl, C2-8 alkylene, C3-8 cycloalkyl, aryl, heteroaryl, heterocycloalkyl, C3-6 cycloalkylaryl, or heterocycloaryl; wherein said alkyl, alkylene, cycloalkyl, aryl, heteroaryl, heterocyclyl, cycloalkylaryl, or heterocycloaryl are unsubstituted or substituted by one or more groups selected from the group consisting of halogen, C1-8 alkyl, C1-8alkoxy, C1-8thioalkoxy, cycloalkyl, aryl, heteroaryl, heterocycloalkyl, CF3, SCF3, NHC(O)nR5, S(O)mR5, S(O)2NR5R6, C(S)NR5R6, CONR5R6, C(O)nR5; n is 0, 1 or 2; m is 0, 1 or 2; R5 is hydrogen, alkyl, aryl, alkylaryl, heterocycloalkyl, or heteroaryl and is unsubstituted or substituted by one or more groups selected from the group consisting of alkyl, C1-8alkoxy, aryl, heteroaryl, halogen, NO2, CN, N3, SCF3, and CF3; R6 is hydrogen, alkyl, aryl, alkylaryl, heterocycloalkyl, or heteroaryl and is unsubstituted or substituted by one or more groups selected from the group consisting of alkyl, C1-8alkoxy, aryl, heteroaryl, halogen, NO2, CN, N3, SCF3, and CF3, or when R1 and/or R2 contains S(O)2NR5R6, CONR5R6, or C(S)NR5R6, then R5R6 together with the nitrogen may form a heterocyclic ring; or a pharmaceutically acceptable salt or solvate thereof.
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Inventors:
Paul Kenneth Spearing
Application Number:
JP2006553161A
Publication Date:
August 09, 2007
Filing Date:
February 03, 2005
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
C07D513/04; A61K31/519; A61P19/10; A61P43/00
Domestic Patent References:
| JPS615082A | 1986-01-10 |
Foreign References:
| DE2336978A1 | 1975-02-06 | |||
| GB1445697B |
Attorney, Agent or Firm:
Mitsuo Tanaka
Tadayuki Motoyama
Kenji Tomita
Tadayuki Motoyama
Kenji Tomita