Title:
細菌性アドヘシンにおける、融合配列、HR1配列およびHR2配列に基づくインヒビター
Document Type and Number:
Japanese Patent JP2008505881
Kind Code:
A
Abstract:
A known surface adhesin (NadA) in Neisseria meningitidis contains sequences which correspond to the fusion peptide, HR1 repeat and HR2 repeat seen in the envelope protein of viruses. Fusion inhibitors may thus be used to inhibit meningococcal infection, and the invention provides a compound that can bind to the heptad repeat sequence(s) HR1 and/or HR2 of the NadA adhesin on the surface of a meningococcus, thereby inhibiting the ability of the meningococcus either to infect a host organism or to spread an existing infection.
Inventors:
Masignani, Vega
Lapuoli, Reno
Capekke, Barbara
Sabino, Silverna
Arico, Maria Beatrice
Lapuoli, Reno
Capekke, Barbara
Sabino, Silverna
Arico, Maria Beatrice
Application Number:
JP2007519915A
Publication Date:
February 28, 2008
Filing Date:
July 06, 2005
Export Citation:
Assignee:
Chiron Sochieta A Responsor Billita Limitata
International Classes:
A61K45/00; A61K38/00; A61P31/04; C07K14/195; C07K14/22; C12N1/21; C12N15/09
Domestic Patent References:
| JP2004508801A | 2004-03-25 |
Foreign References:
| WO2003010194A2 | 2003-02-06 | |||
| WO2003020756A2 | 2003-03-13 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita