Title:
癌治療抵抗性およびかかる抵抗性を調節する薬剤
Document Type and Number:
Japanese Patent JP2008505882
Kind Code:
A
Abstract:
The present invention concerns a method for detecting in vitro resistance of cancer cells to a treatment by detecting in the cancer cells supernumerary nucleolar organizer regions (NOR), whereby identification of the presence of supernumerary NOR in the cancer cells is indicative of treatment resistance. The present invention also concerns a method for defining the capacity of a candidate agent to modulate NOR genes number of cancer cells by contacting the cancer cells with a candidate agent for a time sufficient to permit modulation of NOR genes number; and observing whether NOR genes number increases or decreases in said cancer cells. The present invention also provides a candidate agent that modulates NOR genes number of cancer cells obtained by the method of the invention and a composition for treating and/or preventing a cancer in a patient, comprising said candidate agent. Such a candidate agent decreases the NOR genes number in said cancer cells.
Inventors:
Isabelle and Gourdie
Arnaud, cockle
Bernard, Dutriyo
Guido, Cromer
Bernard, Pau
Arnaud, cockle
Bernard, Dutriyo
Guido, Cromer
Bernard, Pau
Application Number:
JP2007519918A
Publication Date:
February 28, 2008
Filing Date:
July 08, 2005
Export Citation:
Assignee:
Centre National De La Recherche Scientifique (C.N.R.S)
International Classes:
A61K31/282; A61K38/00; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota