Title:
ヒストンデアセチラーゼ阻害剤
Document Type and Number:
Japanese Patent JP2008510821
Kind Code:
A
Abstract:
The invention relates to hydroxamic acid derivatives having carbamate linkage with the structural formula that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and inflammatory diseases, diseases of the central nervous systems (CNS) such as neurodegenerative diseases, and in the prevention and/or treatment of restenosis.
Inventors:
Belvedere, Sandro
Humblett, Christopher Lawrence
Miller, Thomas A
Witter, David The Ray
Yang, Chyamin
Humblett, Christopher Lawrence
Miller, Thomas A
Witter, David The Ray
Yang, Chyamin
Application Number:
JP2007530043A
Publication Date:
April 10, 2008
Filing Date:
August 22, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07C271/22; A61K31/27; A61K31/40; A61K31/426; A61K31/4402; A61K31/5375; A61P1/04; A61P1/14; A61P1/16; A61P1/18; A61P3/02; A61P3/10; A61P5/14; A61P7/00; A61P7/04; A61P9/04; A61P9/08; A61P9/10; A61P9/14; A61P11/00; A61P11/06; A61P13/12; A61P15/06; A61P17/00; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/02; A61P25/08; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P29/02; A61P31/18; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P39/02; A61P39/06; A61P43/00; C07D213/30; C07D277/20; C07D277/46; C07D295/08
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura