Title:
レチノイドを製造する方法およびその使用
Document Type and Number:
Japanese Patent JP2008510822
Kind Code:
A
Abstract:
The present invention relates to a compound having the formula XXX
or
wherein R 1 is a C 5 or greater branched or straight chain alkyl group;
R 2 is hydrogen, a C 1 -C 15 branched or straight chain alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted cycloalkyl group, or R 1 and R 2 collectively form a substituted or unsubstituted fused aryl group; and
R 3 is one or more groups comprising, independently, hydrogen, a C 1 -C 15 branched or straight chain alkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted cycloalkyl group;
R 6 and R 7 are, independently, hydrogen, a C 1 -C 15 branched or straight chain alkyl group, or a substituted or unsubstituted cycloalkyl group;
R 11 is hydrogen or a C 1 -C 15 branched or straight chain alkyl group; and n is from 0 to 3,
wherein one or more carbon atoms in the ring in formula XXX can optionally be replaced with a heteroatom, or the pharmaceutically-acceptable salt or ester thereof,
wherein the compound is not (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H-naphthalen-1'-ylidene))-3,7-dimethyl-2,4,6-octatrienoic acid or an ester thereof; (2E,4E,6E,8E)-8-(3',4'-dihydro-1'(2'H-naphthalen-1'-ylidene))-3,7-dimethyl-2,4,6-octatrienoic acid or an ester thereof; (2E,4E,6Z,8E)-8-(3',4'-dihydro-4'methyl-1'(2'H-naphthalen-1'-ylidene))-3,7-dimethyl-2,4,6-octatrienoic acid or an ester thereof; and (2E,4E,6Z,8E)-8-(3',4'-dihydro-5',7'-dimethyl-1'(2'H-naphthalen-1'-ylidene))-3,7-dimethyl-2,4,6-octatrienoic acid or an ester thereof.
Inventors:
Bluelet, Wayne Jay.
Muccio, Donald Dee.
Attigada, Benkatram Lady
Rupert, John M.
Robo Rupert, Susan M.
Muccio, Donald Dee.
Attigada, Benkatram Lady
Rupert, John M.
Robo Rupert, Susan M.
Application Number:
JP2007530044A
Publication Date:
April 10, 2008
Filing Date:
August 23, 2005
Export Citation:
Assignee:
The UAB Research Foundation
International Classes:
C07C403/20; A61K31/202; A61P35/00; A61P35/02; C07C403/06; C07C403/14; C07D311/96
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita