Title:
改良された抗精神病活性および抗不安症活性を有するイソキサゾリン-インドール誘導体
Document Type and Number:
Japanese Patent JP2008521771
Kind Code:
A
Abstract:
The present invention relates to novel isoxazoline-indole derivatives according to Formula (I), a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, with a binding affinity towards dopamine receptors, in particular towards dopamine D2 and/or D3 receptors, with selective serotonin reuptake inhibition (SSRI) properties and showing an affinity for the 5-HT1A receptor, pharmaceutical compositions comprising the compounds according to the invention, the use thereof for the prevention and/or treatment of a range of psychiatric and neurological disorders, in particular certain psychotic disorders, most in particular schizophrenia and processes for their production, wherein the variables are further defined in the application.
Inventors:
Andre Jill, Jose Ignacio
Bartolome-Nebreda, Jose Manuel
Alcazar-Baka, Manuel Jesuits
Garcia-Martein, Maria de las Mercedes
Mégens, Antonius Adrinus Hendrix Petrus
Bartolome-Nebreda, Jose Manuel
Alcazar-Baka, Manuel Jesuits
Garcia-Martein, Maria de las Mercedes
Mégens, Antonius Adrinus Hendrix Petrus
Application Number:
JP2007541989A
Publication Date:
June 26, 2008
Filing Date:
November 25, 2005
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D498/04; A61K31/4439; A61K31/5377; A61P25/00; A61P25/18; A61P25/22; A61P25/24; A61P43/00; C07D498/14
Domestic Patent References:
| JP2000513731A | 2000-10-17 | |||
| JP2002544223A | 2002-12-24 |
Foreign References:
| WO2004099214A1 | 2004-11-18 | |||
| WO2002066484A1 | 2002-08-29 | |||
| WO2002088142A1 | 2002-11-07 | |||
| WO2002088133A1 | 2002-11-07 |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office
Heikichi Odashima
Heikichi Odashima