Title:
炎症性疾患治療用の置換プテリジン
Document Type and Number:
Japanese Patent JP2008521772
Kind Code:
A
Abstract:
Substituted pteridine compounds (I) and their salts are new. Substituted pteridine compounds of formula (I) and their salt are new. R 1heterocyclic ring which contains a nitrogen atom; R 2aryl, het or hetaryl (all optionally substituted by 1-6C alkyl, O-1-6C alkyl, 3-6C cycloalkyl, 7-11C aralkyl or N(1-4C alkyl) 2), halo, OR 2a, SR 2aor NR 2aR 2b; R 2a, R 2bH, 1-4C alkyl, aryl or 7-11C aralkyl; R 3aryl, het, hetaryl or -X-Y-A-(R 3a) m; A : aryl or hetaryl; X : NR 3b, S or O; Y : 1-4C alkylene (optionally substituted by at least one R 3c; m : 0 - 3; R 3a1-6C alkyl, 1-6C haloalkyl, 1-6C alkyl-CONR 3dR 3e, -1-6C alkyl-NR 3dR 3e, OR 3d, O-1-16C haloalkyl, NHCOR 3d, SO 2R 3d, aryl, halo, CN, OH or CONR 3dR 3e; R 3a+two atoms of A : 5- or 6-membered carbocyclic or heterocyclic ring (which may contain at least one of O or N atoms); R 3b, R 3d, R 3eH or 1-6C alkyl; R 3c1-6C alkyl, 1-6C alkyl-OH, 3-6C cycloalkyl-OH, COOR 3dor CONR 3dR 3e; R 3c+one or two carbon atoms of Y : 3-6C carbocyclic ring; R 4aryl, het or hetaryl (all optionally substituted by at least one of 1-6C alkyl, 1-6C haloalkyl, CN, O-1-16C alkyl or halo), 1-6C alkyl, 2-6 alkenyl, 2-4C alkynyl, 3-6C cycloalkyl, 3-6C cycloalkenyl, OR 4a, SR 4a, 1-6C haloalkyl or NR 4aR 4b; R 4aH, 1-6C alkyl, aryl or 7-11C aralkyl; R 4bH, 1-6C alkyl, aryl or 7-11C aralkyl. [Image] ACTIVITY : Respiratory-Gen.; Gastrointestinal-Gen.; Antiinflammatory; Cytostatic; CNS-Gen.; Antiasthmatic; Antiulcer; Antidepressant; Neuroleptic; Antimanic; Tranquilizer; Nootropic; Neuroprotective; Antiparkinsonian; Analgesic; Vulnerary; Antitussive; Antiallergic; Antirheumatic; Antiarthritic. MECHANISM OF ACTION : Phosphodiesterase 4 (PDE4) inhibitors. No activity data given.
Inventors:
Martiles Domnick
Dringer Horst
Yunk Bilgit
Nicolaus Peter
Dringer Horst
Yunk Bilgit
Nicolaus Peter
Application Number:
JP2007541993A
Publication Date:
June 26, 2008
Filing Date:
November 25, 2005
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07D475/06; A61K31/519; A61K31/5377; A61P1/04; A61P1/08; A61P11/00; A61P11/02; A61P11/06; A61P11/10; A61P17/00; A61P19/02; A61P25/00; A61P25/02; A61P25/04; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07D475/08
Domestic Patent References:
| JPS61140585A | 1986-06-27 | |||
| JPS6025991A | 1985-02-08 | |||
| JP2002533464A | 2002-10-08 |
Foreign References:
| WO2003062240A1 | 2003-07-31 | |||
| US2940972A | 1960-06-14 | |||
| GB763044B |
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama