Title:
抗炎症剤
Document Type and Number:
Japanese Patent JP2008543822
Kind Code:
A
Abstract:
The invention relates inter alia to a compound of general formula (I) or (I'):
wherein
z is 1,2 or 4;
X is -CO-Y k -(R 1 ) n or SO 2 -Y k -(R 1 ) n ;
k is 0 or 1;
Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group);
or is a cycloalkenyl or polycycloalkenyl group;
each R 1 is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms (for example of 5 to 20 carbon atoms, of 8 to 20 carbon atoms, of 9 to 20 carbon atoms, of 10 to 18 carbon atoms, of 12 to 18 carbon atoms, of 13 to 18 carbon atoms, of 14 to 18 carbon atoms, of 13 to 17 carbon atoms);
or each R 1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical; and
n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y (such that n=1 if k=0, such that the R 1 group is bonded directly to the carbonyl or sulfonyl group);
provided that simultaneously X cannot be an undec-10-en-1-oyl group and z be equal to 1 or 2; or
alternatively R 1 is selected from a peptido radical having from 1 to 4 peptidic moieties linked together by peptide bonds.
Inventors:
Granger, David John
Fox, david john
Fox, david john
Application Number:
JP2008516414A
Publication Date:
December 04, 2008
Filing Date:
June 14, 2006
Export Citation:
Assignee:
Cambridge Enterprise Limited
International Classes:
C07D207/273; A61K31/395; A61K31/4015; A61K31/45; A61P9/00; A61P11/06; A61P17/02; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P25/28; A61P29/00; A61P31/12; A61P33/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P41/00; A61P43/00; C07D207/267; C07D211/76; C07D225/02; C07D207/26
Domestic Patent References:
| JP2002536411A | 2002-10-29 | |||
| JP2000507950A | 2000-06-27 |
Foreign References:
| EP0519877A1 | 1992-12-23 |
Other References:
JPN6012027204; Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ Ｎｏ．１２, 1981, ｐ．１６９１-１６９４
JPN6012027205; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．８６， Ｎｏ．１２, 1964, ｐ．２４４１-２４４５
JPN6012027206; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｎｏ．１５, 1975, ｐ．１３０９-１３１２
JPN6012027207; Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ｖｏｌ．３５７, 1986, ｐ．３３５-３３９
JPN6012027208; Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．６３， Ｎｏ．９, 1965, １１６９１ｆ-１１６９３ａ
JPN6012027209; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３１， Ｎｏ．７, 1988, ｐ．１４３０-１４３６
JPN6012027210; Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１６３， Ｎｏ．２, 1987, ２９７-３０２
JPN6012027211; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１１５， Ｎｏ．２３, 1993, ｐ．１０４９２-１０４９６
JPN6012027212; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７７, 1955, ｐ．６６９０-６６９１
JPN6012027213; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１０２， Ｎｏ．１５, 1980, ｐ．４８５５-４８６３
JPN6012027214; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｃ：Ｏｒｇａｎｉｃ Ｎｏ．２２, 1971, ｐ．３７４３-３７４８
JPN6012027215; ＩＬ ＦＡＲＭＡＣＯ Ｖｏｌ．５９， Ｎｏ．４, 2004, ２７１-２７７
JPN6012027216; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４８， Ｎｏ．３, 2005, ８６７-８７４
JPN6012027205; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．８６， Ｎｏ．１２, 1964, ｐ．２４４１-２４４５
JPN6012027206; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ Ｎｏ．１５, 1975, ｐ．１３０９-１３１２
JPN6012027207; Ｊｏｕｒｎａｌ ｏｆ Ｃｈｒｏｍａｔｏｇｒａｐｈｙ Ｖｏｌ．３５７, 1986, ｐ．３３５-３３９
JPN6012027208; Ｃｈｅｍｉｃａｌ Ａｂｓｔｒａｃｔｓ Ｖｏｌ．６３， Ｎｏ．９, 1965, １１６９１ｆ-１１６９３ａ
JPN6012027209; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３１， Ｎｏ．７, 1988, ｐ．１４３０-１４３６
JPN6012027210; Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１６３， Ｎｏ．２, 1987, ２９７-３０２
JPN6012027211; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１１５， Ｎｏ．２３, 1993, ｐ．１０４９２-１０４９６
JPN6012027212; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．７７, 1955, ｐ．６６９０-６６９１
JPN6012027213; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｖｏｌ．１０２， Ｎｏ．１５, 1980, ｐ．４８５５-４８６３
JPN6012027214; Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ Ｃ：Ｏｒｇａｎｉｃ Ｎｏ．２２, 1971, ｐ．３７４３-３７４８
JPN6012027215; ＩＬ ＦＡＲＭＡＣＯ Ｖｏｌ．５９， Ｎｏ．４, 2004, ２７１-２７７
JPN6012027216; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４８， Ｎｏ．３, 2005, ８６７-８７４
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Kazumi Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Kazumi Nakamura