アセチルコリンエステラーゼ阻害剤として有用な薬剤組成物 - Council of Scientific and Industrial Research

Title:

アセチルコリンエステラーゼ阻害剤として有用な薬剤組成物

Document Type and Number:

Japanese Patent JP2009531323

Kind Code:

A

Abstract:

The present invention relates to pharmaceutical composition comprising the naturally occurring compounds selected from (±) Marrnesin, Columbianetin, Dihydroxanthyletin and substituted coumarin derivatives of 7-allyloxy coumarin, 7-benzyloxy coumarin, 7 -methoxycoumarin, 7-acetyloxy coumarin, 4-methyl-7-hydroxy coumarin and 4-methyl-7-acetyloxy coumarin. The said compositions possess a high degree of acetylcholinesterase inhibitory (AChE) property.

Inventors:

Lao, Janaswamy, Madusdana
Bimapaca, China, Raju
Prara, Benkata, Srinivas
Katra Gadda, Shresh, Baboo
Yadav, Gilew, Shin
Condapram, Vijaya, Loughbang
Shin, Heman, Kumar
Eggplant, chandiswa

Application Number:

JP2009500954A

Publication Date:

September 03, 2009

Filing Date:

March 19, 2007

Export Citation:

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Assignee:

Council of Scientific and Industrial Research

International Classes:

A61K31/37; A61K47/36; A61K47/38; A61P25/28; A61P43/00; C07D311/16; C07D493/04

Domestic Patent References:

JP2006520368A

2006-09-07

Foreign References:

WO2004082706A2

2004-09-30

Other References:

JPN6012046566; 'Ｄｅｃｕｒｓｉｎ　ｆｒｏｍ　Ａｎｇｅｌｉｃａ　ｇｉｇａｓ　ｍｉｔｉｇａｔｅｓ　ａｍｎｅｓｉａ　ｉｎｄｕｃｅｄ　ｂｙ　ｓｃｏｐｏｌａｍｉｎｅ　ｉｎ　ｍｉｃｅ' Ｎｅｕｒｏｂｉｏｌ　Ｌｅａｒｎ　ＭｅｍＶｏｌ．７９，　Ｎｏ．１, 2003, ｐ．１１-８
JPN6012046567; ＫＡＮＧ，Ｓ．Ｙ．　ｅｔ　ａｌ: 'Ｃｏｕｍａｒｉｎｓ　ｉｓｏｌａｔｅｄ　ｆｒｏｍ　Ａｎｇｅｌｉｃａ　ｇｉｇａｓ　ｉｎｈｉｂｉｔ　ａｃｅｔｙｌｃｈｏｌｉｎｅｓｔｅｒａｓｅ：　ｓｔｒｕｃｔｕｒｅ-ａｃｔｉｖｉｔｙ　ｒｅｌａｔｉｏｎｓｈｉｐ' Ｊ　Ｎａｔ　ＰｒｏｄＶｏｌ．６４，　Ｎｏ．５, 2001, ｐ．６８３-５
JPN6012046569; ＢＲＵＨＬＭＡＮＮ，Ｃ．　ｅｔ　ａｌ: 'Ｃｏｕｍａｒｉｎｓ　ｄｅｒｉｖａｔｉｖｅｓ　ａｓ　ｄｕａｌ　ｉｎｈｉｂｉｔｏｒｓ　ｏｆ　ａｃｅｔｙｌｃｈｏｌｉｎｅｓｔｅｒａｓｅ　ａｎｄ　ｍｏｎｏａｍｉｎｅ　ｏｘｉｄａｓｅ' Ｊ　Ｍｅｄ　ＣｈｅｍＶｏｌ．４４，　Ｎｏ．１９, 2001, ｐ．３１９５-８

Attorney, Agent or Firm:

Shohei Oguri
Hironori Honda
Toshimitsu Ichikawa

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