Title:
癌標的化のための操作された抗前立腺幹細胞抗原(PSCA)抗体
Document Type and Number:
Japanese Patent JP2009531324
Kind Code:
A
Abstract:
The invention provides novel humanized antibody fragments that specifically bind prostate cell-surface antigen (PSCA), a protein which is overexpressed in variety of cancers, including prostate, bladder, and pancreatic cancer. Methods are provided for the use of the compositions of the invention for the treatment of cancer, diagnosis of cancer, to provide a prognosis of cancer progression, and for cancer imaging.
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Inventors:
Wu, Anna Em.
Writer, Robert E.
Writer, Robert E.
Application Number:
JP2009501542A
Publication Date:
September 03, 2009
Filing Date:
March 20, 2007
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
C07K16/30; A61B5/055; A61K39/395; A61K49/00; A61K51/00; A61P1/18; A61P13/08; A61P13/10; A61P35/00; C12N15/09; G01N33/574
Domestic Patent References:
| JP2003504414A | 2003-02-04 |
Other References:
JPN6012031948; ＧＵ， Ｚ．， ｅｔ ａｌ．: 'Ｂｉｏｌｏｇｉｃａｌ ａｃｔｉｖｉｔｙ ａｎｄ ｍｉｃｒｏＰＥＴ ｉｍａｇｉｎｇ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ｃｈｉｍｅｒｉｃ ａｎｄ ｈｕｍａｎｉｚｅｄ ａｎｔｉ-ｐｒｏｓｔａｔｅ ｓｔｅｍ ｃｅｌ' Ｐｒｏｃ Ａｍｅｒ Ａｓｓｏｃ Ｃａｎｃｅｒ Ｒｅｓ． Ｖｏｌ．４６, 2005
JPN6013010083; ＴＯＤＯＲＯＶＳＫＡ， Ａ． ｅｔ ａｌ．: Ｊ Ｉｍｍｕｎｏｌ Ｍｅｔｈｏｄｓ． Ｖｏｌ．２４８, 20010201, ｐ．４７-６６
JPN6013010083; ＴＯＤＯＲＯＶＳＫＡ， Ａ． ｅｔ ａｌ．: Ｊ Ｉｍｍｕｎｏｌ Ｍｅｔｈｏｄｓ． Ｖｏｌ．２４８, 20010201, ｐ．４７-６６
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita