Title:
キナーゼ阻害剤としてのイミダゾトリアジンおよびイミダゾピリミジン
Document Type and Number:
Japanese Patent JP2010510319
Kind Code:
A
Abstract:
The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.
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Inventors:
Zincon Juo
Magion Sue
He Chun Hong
Chan Colin
Kian Din-Kuan
David M. Burns
Yun Long Li
Brian Metcalfe
Wenkin Yao
Magion Sue
He Chun Hong
Chan Colin
Kian Din-Kuan
David M. Burns
Yun Long Li
Brian Metcalfe
Wenkin Yao
Application Number:
JP2009538473A
Publication Date:
April 02, 2010
Filing Date:
November 19, 2007
Export Citation:
Assignee:
INCYTE CORPORATION
International Classes:
C07D487/04; A61K31/519; A61K31/53; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P29/00; A61P35/00; A61P37/06; A61P37/08; A61P43/00
Domestic Patent References:
| JP2008540535A | 2008-11-20 | |||
| JP2004521916A | 2004-07-22 | |||
| JP2001043978A | 2001-02-16 | |||
| JP2008540535A | 2008-11-20 | |||
| JP2004521916A | 2004-07-22 |
Foreign References:
| WO2006015123A1 | 2006-02-09 | |||
| WO2005010005A1 | 2005-02-03 | |||
| WO2006049339A1 | 2006-05-11 | |||
| WO2006015123A1 | 2006-02-09 | |||
| WO2005010005A1 | 2005-02-03 | |||
| WO2006049339A1 | 2006-05-11 |
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JPN5009019382; ＳＩＬＶＡＮＯ ＲＯＳＳＩ: ＬＡ ＣＨＭＩＣＡ Ｅ Ｌ'ＩＮＤＵＳＴＲＩＡ Ｖ４０, 1958, Ｐ８２７-８３０, ＳＯＣＩＥＴＡ ＣＨＩＭＩＣＡ ＩＴＡＬＩＡＮＯ
JPN5009019399; ＫＲＵＧＬＥＮＫＯ Ｖ Ｐ: ＣＨＥＭＩＳＴＲＹ ＯＦ ＨＥＴＥＲＯＣＹＣＬＩＣ ＣＯＭＰＯＵＮＤＳ Ｖ３４ Ｎ２, 1998, Ｐ２３２-２３６, ＰＬＥＮＵＭ ＰＲＥＳＳ ＣＯ．
JPN5009019402; Ａ．ＶＩＤＡＬ: ＩＮＦＬＡＭＭＡＴＩＯＮ ＲＥＳＥＡＲＣＨ Ｖ５０, 2001, Ｐ３１７-３２０
JPN6013005514; ＰＯＶＳＴＹＡＮＯＩ，Ｍ．Ｖ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｓｐｅｃｔｒａｌ ｃｈａｒａｃｔｅｒｉｓｔｉｃｓ ｏｆ ｎｏｖｅｌ ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ｉｍｉｄａｚｏ［１，２-ｂ］-１，２，４-ｔｒｉａｚｉｎｅ' Ｉｚｖｅｓｔｉｙａ Ｔｉｍｉｒｙａｚｅｖｓｋｏｉ Ｓｅｌ'ｓｋｏｋｈｏｚｙａｉｓｔｖｅｎｎｏｉ Ａｋａｄｅｍｉｉ Ｎｏ．５, 1984, ｐ．１５５-１５９
JPN5009019382; ＳＩＬＶＡＮＯ ＲＯＳＳＩ: ＬＡ ＣＨＭＩＣＡ Ｅ Ｌ'ＩＮＤＵＳＴＲＩＡ Ｖ４０, 1958, Ｐ８２７-８３０, ＳＯＣＩＥＴＡ ＣＨＩＭＩＣＡ ＩＴＡＬＩＡＮＯ
JPN5009019399; ＫＲＵＧＬＥＮＫＯ Ｖ Ｐ: ＣＨＥＭＩＳＴＲＹ ＯＦ ＨＥＴＥＲＯＣＹＣＬＩＣ ＣＯＭＰＯＵＮＤＳ Ｖ３４ Ｎ２, 1998, Ｐ２３２-２３６, ＰＬＥＮＵＭ ＰＲＥＳＳ ＣＯ．
JPN5009019402; Ａ．ＶＩＤＡＬ: ＩＮＦＬＡＭＭＡＴＩＯＮ ＲＥＳＥＡＲＣＨ Ｖ５０, 2001, Ｐ３１７-３２０
JPN6013005514; ＰＯＶＳＴＹＡＮＯＩ，Ｍ．Ｖ． ｅｔ ａｌ: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｓｐｅｃｔｒａｌ ｃｈａｒａｃｔｅｒｉｓｔｉｃｓ ｏｆ ｎｏｖｅｌ ｄｅｒｉｖａｔｉｖｅｓ ｏｆ ｉｍｉｄａｚｏ［１，２-ｂ］-１，２，４-ｔｒｉａｚｉｎｅ' Ｉｚｖｅｓｔｉｙａ Ｔｉｍｉｒｙａｚｅｖｓｋｏｉ Ｓｅｌ'ｓｋｏｋｈｏｚｙａｉｓｔｖｅｎｎｏｉ Ａｋａｄｅｍｉｉ Ｎｏ．５, 1984, ｐ．１５５-１５９
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto