Title:
メシル酸イマチニブの安定化非結晶形態
Document Type and Number:
Japanese Patent JP2010529964
Kind Code:
A
Abstract:
The invention relates to the stabilized amorphous form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)-pyrimidin-2-ylamino)-phenyl]-benzamide, pharmaceutical compositions such as capsules or tablets containing this form, the use of such form in diagnostic methods or, preferably, for the therapeutic treatment of warm-blooded animals, especially humans, and the use of formulation principles stabilizing the amorphous form of Imatinib mesylate as an intermediate for the preparation of pharmaceutical compositions.
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Inventors:
Elisabeth Goncalves
Oscar Calve
Michael Muts
Wolfgang Wild
Jay Pershban Lakshman
Oscar Calve
Michael Muts
Wolfgang Wild
Jay Pershban Lakshman
Application Number:
JP2010511312A
Publication Date:
September 02, 2010
Filing Date:
June 05, 2008
Export Citation:
Assignee:
Novartis Age
International Classes:
A61K31/506; A61K9/20; A61K9/48; A61K47/40; A61P35/02
Domestic Patent References:
| JP2000229887A | 2000-08-22 | |||
| JP2010521477A | 2010-06-24 | |||
| JP2000229887A | 2000-08-22 | |||
| JP2010521477A | 2010-06-24 |
Foreign References:
| WO2006121941A2 | 2006-11-16 | |||
| WO2006021657A1 | 2006-03-02 | |||
| WO2005123076A2 | 2005-12-29 | |||
| WO2006121941A2 | 2006-11-16 | |||
| WO2006021657A1 | 2006-03-02 | |||
| WO2005123076A2 | 2005-12-29 |
Other References:
JPN6012043819; ＢＥＮＩ，Ｓ． ｅｔ ａｌ: ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＳＣＩＥＮＣＥＳ Ｖｏｌ．３０, 2007, ｐ．１６７-１７４
JPN6012043819; ＢＥＮＩ，Ｓ． ｅｔ ａｌ: ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＳＣＩＥＮＣＥＳ Ｖｏｌ．３０, 2007, ｐ．１６７-１７４
JPN6012043819; ＢＥＮＩ，Ｓ． ｅｔ ａｌ: ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＳＣＩＥＮＣＥＳ Ｖｏｌ．３０, 2007, ｐ．１６７-１７４
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa
Yasushi Ochiai
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa
Yasushi Ochiai