Title:
鎮痛作用とASICチャンネルを阻害する新規ペプチド
Document Type and Number:
Japanese Patent JP2013535965
Kind Code:
A
Abstract:
Novel isolated peptides which induce analgesia and which inhibit ASIC channels (Acid Sensing Ion Channels), to the polynucleotides encoding these peptides, and also to the pharmaceutical compositions, host cells, and vectors comprising these peptides and the polynucleotides encoding these peptides. In particular, these peptides are isolated from the venom of the snake Dendroaspis polylepis. The present invention also relates to the use of these peptides as a diagnostic tool or as a medicament, particularly as an analgesic, or for identifying analgesic molecules or molecules which inhibit ASIC channels.
Inventors:
Ring Eglia, Eric
Diochott, Sylvia
Baron-Foster, Anne
Salina, Miguel
Michelle Rasunsky
Diochott, Sylvia
Baron-Foster, Anne
Salina, Miguel
Michelle Rasunsky
Application Number:
JP2013521194A
Publication Date:
September 19, 2013
Filing Date:
July 26, 2011
Export Citation:
Assignee:
Centre National De La Recherche Scientifique
International Classes:
C12N15/09; A61K31/7088; A61K35/12; A61K35/76; A61K38/00; A61K48/00; A61P1/04; A61P9/10; A61P19/00; A61P21/00; A61P25/00; A61P25/04; A61P25/22; A61P25/24; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07K14/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/68; G01N33/15; G01N33/50; C12Q1/02
Domestic Patent References:
| JP2007306866A | 2007-11-29 | |||
| JP2008193923A | 2008-08-28 |
Other References:
JPN6015017191; ＬＩＡＮＧ， Ｌ．Ｘ． ｅｔ ａｌ．: '"Ｐｅｒｉｐｈｅｒａｌ ａｎｄ ｓｐｉｎａｌ ａｎｔｉｈｙｐｅｒａｌｇｅｓｉｃ ａｃｔｉｖｉｔｙ ｏｆ ｎａｊａｎａｌｇｅｓｉｎ ｉｓｏｌａｔｅｄ ｆｒｏｍ Ｎａｊａ ｎａｊａ ａｔｒａ ｉｎ ａ ｒ' ＮＥＵＲＯＳＣＩ． ＬＥＴＴ． Ｖｏｌ．４６０， Ｎｏ．３, 20090904, Ｐ．１９１-１９５
JPN6015017194; ＪＯＵＢＥＲＴ， Ｆ．Ｊ．: '"Ｔｈｅ ａｍｉｎｏ ａｃｉｄ ｓｅｑｕｅｎｃｅ ｏｆ ｐｒｏｔｅｉｎ ＣＭ-３ ｆｒｏｍ Ｄｅｎｄｒｏａｓｐｉｓ ｐｏｌｙｌｅｐｉｓ ｐｏｌｙｌｅｐｉｓ （ｂｌａｃｋ ｍａｍｂａ） ｖｅｎｏｍ．"' ＩＮＴ． Ｊ． ＢＩＯＣＨＥＭ． Ｖｏｌ．１７， Ｎｏ．６, 1985, Ｐ．６９５-６９９
JPN6015017197; ＭＯＬＬＡＹ， Ｃ． ｅｔ ａｌ．: '"Ｂｖ８， ａ ｓｍａｌｌ ｐｒｏｔｅｉｎ ｆｒｏｍ ｆｒｏｇ ｓｋｉｎ ａｎｄ ｉｔｓ ｈｏｍｏｌｏｇｕｅ ｆｒｏｍ ｓｎａｋｅ ｖｅｎｏｍ ｉｎｄｕｃｅ ｈｙｐｅｒａｌｇｅｓｉａ ｉｎ ｒａｔｓ．' ＥＵＲ． Ｊ． ＰＨＡＲＭＡＣＯＬ． Ｖｏｌ．３７４， Ｎｏ．２, 19990618, Ｐ．１８９-１９６
JPN6015017200; ＤＩＯＣＨＯＴ， Ｓ． ｅｔ ａｌ．: '"Ｂｌａｃｋ ｍａｍｂａ ｖｅｎｏｍ ｐｅｐｔｉｄｅｓ ｔａｒｇｅｔ ａｃｉｄ-ｓｅｎｓｉｎｇ ｉｏｎ ｃｈａｎｎｅｌｓ ｔｏ ａｂｏｌｉｓｈ ｐａｉｎ．"' ＮＡＴＵＲＥ Ｖｏｌ．４９０， Ｎｏ．７４２１, 20121025, Ｐ．５５２-５５５
JPN6015017189; ＪＯＵＢＥＲＴ， Ｆ．Ｊ．: '"Ｓｎａｋｅ ｖｅｎｏｍ ｔｏｘｉｎｓ． Ｔｈｅ ａｍｉｎｏ ａｃｉｄ ｓｅｑｕｅｎｃｅｓ ｏｆ ｔｗｏ ｔｏｘｉｎｓ （ＣＭ-２ａ ａｎｄ ＣＭ-３） ｆｒｏｍ Ｎａｊａ ｈａｊｅ ａｎｎｕｌｉｆｅ' ＨＯＰＰＥ-ＳＥＹＬＥＲ'Ｓ Ｚ． ＰＨＹＳＩＯＬ． ＣＨＥＭ． Ｖｏｌ．３５８， Ｎｏ．３, 197703, Ｐ．３７７-３９０
JPN6015017191; ＬＩＡＮＧ， Ｌ．Ｘ． ｅｔ ａｌ．: '"Ｐｅｒｉｐｈｅｒａｌ ａｎｄ ｓｐｉｎａｌ ａｎｔｉｈｙｐｅｒａｌｇｅｓｉｃ ａｃｔｉｖｉｔｙ ｏｆ ｎａｊａｎａｌｇｅｓｉｎ ｉｓｏｌａｔｅｄ ｆｒｏｍ Ｎａｊａ ｎａｊａ ａｔｒａ ｉｎ ａ ｒ' ＮＥＵＲＯＳＣＩ． ＬＥＴＴ． Ｖｏｌ．４６０， Ｎｏ．３, 20090904, Ｐ．１９１-１９５
JPN6015017194; ＪＯＵＢＥＲＴ， Ｆ．Ｊ．: '"Ｔｈｅ ａｍｉｎｏ ａｃｉｄ ｓｅｑｕｅｎｃｅ ｏｆ ｐｒｏｔｅｉｎ ＣＭ-３ ｆｒｏｍ Ｄｅｎｄｒｏａｓｐｉｓ ｐｏｌｙｌｅｐｉｓ ｐｏｌｙｌｅｐｉｓ （ｂｌａｃｋ ｍａｍｂａ） ｖｅｎｏｍ．"' ＩＮＴ． Ｊ． ＢＩＯＣＨＥＭ． Ｖｏｌ．１７， Ｎｏ．６, 1985, Ｐ．６９５-６９９
JPN6015017197; ＭＯＬＬＡＹ， Ｃ． ｅｔ ａｌ．: '"Ｂｖ８， ａ ｓｍａｌｌ ｐｒｏｔｅｉｎ ｆｒｏｍ ｆｒｏｇ ｓｋｉｎ ａｎｄ ｉｔｓ ｈｏｍｏｌｏｇｕｅ ｆｒｏｍ ｓｎａｋｅ ｖｅｎｏｍ ｉｎｄｕｃｅ ｈｙｐｅｒａｌｇｅｓｉａ ｉｎ ｒａｔｓ．' ＥＵＲ． Ｊ． ＰＨＡＲＭＡＣＯＬ． Ｖｏｌ．３７４， Ｎｏ．２, 19990618, Ｐ．１８９-１９６
JPN6015017200; ＤＩＯＣＨＯＴ， Ｓ． ｅｔ ａｌ．: '"Ｂｌａｃｋ ｍａｍｂａ ｖｅｎｏｍ ｐｅｐｔｉｄｅｓ ｔａｒｇｅｔ ａｃｉｄ-ｓｅｎｓｉｎｇ ｉｏｎ ｃｈａｎｎｅｌｓ ｔｏ ａｂｏｌｉｓｈ ｐａｉｎ．"' ＮＡＴＵＲＥ Ｖｏｌ．４９０， Ｎｏ．７４２１, 20121025, Ｐ．５５２-５５５
JPN6015017194; ＪＯＵＢＥＲＴ， Ｆ．Ｊ．: '"Ｔｈｅ ａｍｉｎｏ ａｃｉｄ ｓｅｑｕｅｎｃｅ ｏｆ ｐｒｏｔｅｉｎ ＣＭ-３ ｆｒｏｍ Ｄｅｎｄｒｏａｓｐｉｓ ｐｏｌｙｌｅｐｉｓ ｐｏｌｙｌｅｐｉｓ （ｂｌａｃｋ ｍａｍｂａ） ｖｅｎｏｍ．"' ＩＮＴ． Ｊ． ＢＩＯＣＨＥＭ． Ｖｏｌ．１７， Ｎｏ．６, 1985, Ｐ．６９５-６９９
JPN6015017197; ＭＯＬＬＡＹ， Ｃ． ｅｔ ａｌ．: '"Ｂｖ８， ａ ｓｍａｌｌ ｐｒｏｔｅｉｎ ｆｒｏｍ ｆｒｏｇ ｓｋｉｎ ａｎｄ ｉｔｓ ｈｏｍｏｌｏｇｕｅ ｆｒｏｍ ｓｎａｋｅ ｖｅｎｏｍ ｉｎｄｕｃｅ ｈｙｐｅｒａｌｇｅｓｉａ ｉｎ ｒａｔｓ．' ＥＵＲ． Ｊ． ＰＨＡＲＭＡＣＯＬ． Ｖｏｌ．３７４， Ｎｏ．２, 19990618, Ｐ．１８９-１９６
JPN6015017200; ＤＩＯＣＨＯＴ， Ｓ． ｅｔ ａｌ．: '"Ｂｌａｃｋ ｍａｍｂａ ｖｅｎｏｍ ｐｅｐｔｉｄｅｓ ｔａｒｇｅｔ ａｃｉｄ-ｓｅｎｓｉｎｇ ｉｏｎ ｃｈａｎｎｅｌｓ ｔｏ ａｂｏｌｉｓｈ ｐａｉｎ．"' ＮＡＴＵＲＥ Ｖｏｌ．４９０， Ｎｏ．７４２１, 20121025, Ｐ．５５２-５５５
JPN6015017189; ＪＯＵＢＥＲＴ， Ｆ．Ｊ．: '"Ｓｎａｋｅ ｖｅｎｏｍ ｔｏｘｉｎｓ． Ｔｈｅ ａｍｉｎｏ ａｃｉｄ ｓｅｑｕｅｎｃｅｓ ｏｆ ｔｗｏ ｔｏｘｉｎｓ （ＣＭ-２ａ ａｎｄ ＣＭ-３） ｆｒｏｍ Ｎａｊａ ｈａｊｅ ａｎｎｕｌｉｆｅ' ＨＯＰＰＥ-ＳＥＹＬＥＲ'Ｓ Ｚ． ＰＨＹＳＩＯＬ． ＣＨＥＭ． Ｖｏｌ．３５８， Ｎｏ．３, 197703, Ｐ．３７７-３９０
JPN6015017191; ＬＩＡＮＧ， Ｌ．Ｘ． ｅｔ ａｌ．: '"Ｐｅｒｉｐｈｅｒａｌ ａｎｄ ｓｐｉｎａｌ ａｎｔｉｈｙｐｅｒａｌｇｅｓｉｃ ａｃｔｉｖｉｔｙ ｏｆ ｎａｊａｎａｌｇｅｓｉｎ ｉｓｏｌａｔｅｄ ｆｒｏｍ Ｎａｊａ ｎａｊａ ａｔｒａ ｉｎ ａ ｒ' ＮＥＵＲＯＳＣＩ． ＬＥＴＴ． Ｖｏｌ．４６０， Ｎｏ．３, 20090904, Ｐ．１９１-１９５
JPN6015017194; ＪＯＵＢＥＲＴ， Ｆ．Ｊ．: '"Ｔｈｅ ａｍｉｎｏ ａｃｉｄ ｓｅｑｕｅｎｃｅ ｏｆ ｐｒｏｔｅｉｎ ＣＭ-３ ｆｒｏｍ Ｄｅｎｄｒｏａｓｐｉｓ ｐｏｌｙｌｅｐｉｓ ｐｏｌｙｌｅｐｉｓ （ｂｌａｃｋ ｍａｍｂａ） ｖｅｎｏｍ．"' ＩＮＴ． Ｊ． ＢＩＯＣＨＥＭ． Ｖｏｌ．１７， Ｎｏ．６, 1985, Ｐ．６９５-６９９
JPN6015017197; ＭＯＬＬＡＹ， Ｃ． ｅｔ ａｌ．: '"Ｂｖ８， ａ ｓｍａｌｌ ｐｒｏｔｅｉｎ ｆｒｏｍ ｆｒｏｇ ｓｋｉｎ ａｎｄ ｉｔｓ ｈｏｍｏｌｏｇｕｅ ｆｒｏｍ ｓｎａｋｅ ｖｅｎｏｍ ｉｎｄｕｃｅ ｈｙｐｅｒａｌｇｅｓｉａ ｉｎ ｒａｔｓ．' ＥＵＲ． Ｊ． ＰＨＡＲＭＡＣＯＬ． Ｖｏｌ．３７４， Ｎｏ．２, 19990618, Ｐ．１８９-１９６
JPN6015017200; ＤＩＯＣＨＯＴ， Ｓ． ｅｔ ａｌ．: '"Ｂｌａｃｋ ｍａｍｂａ ｖｅｎｏｍ ｐｅｐｔｉｄｅｓ ｔａｒｇｅｔ ａｃｉｄ-ｓｅｎｓｉｎｇ ｉｏｎ ｃｈａｎｎｅｌｓ ｔｏ ａｂｏｌｉｓｈ ｐａｉｎ．"' ＮＡＴＵＲＥ Ｖｏｌ．４９０， Ｎｏ．７４２１, 20121025, Ｐ．５５２-５５５
Attorney, Agent or Firm:
Tadashige Ito
Tadahiko Ito
Shinsuke Onuki
Tadahiko Ito
Shinsuke Onuki