Title:
診断および治療におけるR2R1/2
Document Type and Number:
Japanese Patent JP2014507943
Kind Code:
A
Abstract:
The present invention stems from the finding that two genes designated R2R1and R2R2, play important roles in tissue development and cancer biology. In particular, the inventors have discovered that these two genes are expressed in pulmonary cells and are required for late branching morphogenesis of pulmonary epithelium and endothelium and support the development/maintenance of the refined three dimensional architecture of the lung. These genes are essential in the squamous differentiation program and development/ maintenance of the progenitor (Krtl4 expressing) cell pool. Moreover, the inventors have identified crucial roles for these genes in cancer biology, particularly processes associated with the acquisition of an immortal and metastatic phenotype (including cancer progression and metastasis) and pulmonary and cardiac development. Accordingly, the invention provides compounds and methods for use in the treatment of cardiac and pulmonary diseases and well as in cancer.
Inventors:
De Luiter Marx Cornelis
Defoot Ronald Antonius
Peters Peter Johann
Fun Brenpt Ronald Karel Louisa
Assen's Jerone Marcel Maria Roger
Defoot Ronald Antonius
Peters Peter Johann
Fun Brenpt Ronald Karel Louisa
Assen's Jerone Marcel Maria Roger
Application Number:
JP2013552287A
Publication Date:
April 03, 2014
Filing Date:
February 02, 2012
Export Citation:
Assignee:
Academia Sieken Heiss Reiden Ar/You Reiden Uni Medical Seteer
Janssen Pharmaceuticals NAMROSE FENNOTE SHAP
Janssen Pharmaceuticals NAMROSE FENNOTE SHAP
International Classes:
C12N15/09; A01K67/027; A61K31/7088; A61K38/00; A61K39/395; A61K48/00; A61P9/00; A61P11/00; A61P35/00; C07K14/47; C07K16/18; C12N15/113; C12Q1/68; G01N33/53; G01N33/68
Other References:
JPN6016002072; ＲｅｃＮａｍｅ： Ｆｕｌｌ＝Ｐｒｏｔｅｉｎ ＦＡＭ２５． , 20101130
JPN6016002074; ＲｅｃＮａｍｅ： Ｆｕｌｌ＝Ｐｒｏｔｅｉｎ ＦＡＭ２５． , 20110111
JPN6016002075; ＲｅｃＮａｍｅ： Ｆｕｌｌ＝ＵＰＦ０５７４ ｐｒｏｔｅｉｎ Ｃ９ｏｒｆ１６９ ｈｏｍｏｌｏｇ． , 20101130
JPN6016002076; ＳｕｂＮａｍｅ： Ｆｕｌｌ＝Ｎｏｖｅｌ ｐｒｏｔｅｉｎ , 20101005
JPN6016002074; ＲｅｃＮａｍｅ： Ｆｕｌｌ＝Ｐｒｏｔｅｉｎ ＦＡＭ２５． , 20110111
JPN6016002075; ＲｅｃＮａｍｅ： Ｆｕｌｌ＝ＵＰＦ０５７４ ｐｒｏｔｅｉｎ Ｃ９ｏｒｆ１６９ ｈｏｍｏｌｏｇ． , 20101130
JPN6016002076; ＳｕｂＮａｍｅ： Ｆｕｌｌ＝Ｎｏｖｅｌ ｐｒｏｔｅｉｎ , 20101005
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Toshio Takizawa
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Toshio Takizawa