Title:
ASYMMETRICAL REVERSIBLE NEUROMUSCULAR BLOCKING SUBSTANCE WITH SUPER SHORT, SHORT OR MIDDLE DURATION TIME
Document Type and Number:
Japanese Patent JP2018048183
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a neuromuscular blocking compound.SOLUTION: A pharmaceutical composition contains a biocompatible solvent and a compound represented by formula (I). In the pharmaceutical composition, the biocompatible solvent contains a compound which contains 0.9% saline water, has a pH of approximately 2.5 to 3.5, has a concentration of approximately 1-10 mg/ml and is represented by formula (I). A kit contains the pharmaceutical composition in a first container and a thiol compound in a second container. A method includes reacting alcohol having a right edge or a left edge of formula (I) with a maleic anhydride or dichlorosuccinic anhydride, and reacting the obtained reaction product with alcohol on the other end to produce the compound represented by formula (I).SELECTED DRAWING: Figure 4
Inventors:
JOHN J SAVARESE
JEFF D MCGILVRA
JEFF D MCGILVRA
Application Number:
JP2017207722A
Publication Date:
March 29, 2018
Filing Date:
October 27, 2017
Export Citation:
Assignee:
UNIV CORNELL
International Classes:
C07D217/20; A61K9/14; A61K31/198; A61K31/5377; A61K31/7076; A61P21/02; A61P25/02; C07D405/12
Domestic Patent References:
| JP2015522033A | 2015-08-03 | |||
| JP6236077B2 | 2017-11-22 | |||
| JP2002503220A | 2002-01-29 |
Foreign References:
| WO2010107488A1 | 2010-09-23 | |||
| WO2003070243A1 | 2003-08-28 |
Other References:
HAINING, C. G. ET AL.: "The neuromuscular blocking properties of a series of bis-quaternary tropeines", BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, vol. 15(1), JPN6017005889, 1960, pages pp. 71-81
URBANSKY, MAREK ET AL.: "Truxillic acid derivatives, neuromuscular blocking agents with very high affinity for the allosteric", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 64(12), JPN6017005891, 1999, pages pp. 1980-1992
BOWMAN, W. C.: "Neuromuscular block", BRITISH JOURNAL OF PHARMACOLOGY, vol. 147(S1), JPN6017005893, 2006, pages pp. S277-S286
URBANSKY, MAREK ET AL.: "Truxillic acid derivatives, neuromuscular blocking agents with very high affinity for the allosteric", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 64(12), JPN6017005891, 1999, pages pp. 1980-1992
BOWMAN, W. C.: "Neuromuscular block", BRITISH JOURNAL OF PHARMACOLOGY, vol. 147(S1), JPN6017005893, 2006, pages pp. S277-S286
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto