Title:
BMP-ALK3 ANTAGONIST AND USE FOR PROMOTING BONE GROWTH
Document Type and Number:
Japanese Patent JP2019146568
Kind Code:
A
Abstract:
To provide a BMP-ALK3 antagonist and a use for promoting bone growth.SOLUTION: According to the present invention, there are provided a composition and method for promoting bone growth and increasing bone density and strength, and an ALK3 polypeptide that includes an ALK3-Fc fusion protein. According to the present invention, a soluble form of ALK3 acts as an inhibitor of BMP-ALK3 signaling and promotes increased bone density, bone growth, and bone strength in vivo. While not wishing to be bound to any particular mechanism, it appears that the soluble form of ALK3 achieves this effect by inhibiting BMP2 and/or BMP4, and perhaps other ligands that signal through ALK3.SELECTED DRAWING: Figure 15
Inventors:
JASBIR SEEHRA
Application Number:
JP2019041216A
Publication Date:
September 05, 2019
Filing Date:
March 07, 2019
Export Citation:
Assignee:
ACCELERON PHARMA INC
International Classes:
C12N15/12; A61K31/565; A61K31/59; A61K31/663; A61K33/06; A61K38/22; A61K38/23; A61K38/29; A61K38/43; A61K39/395; A61K45/00; A61K47/64; A61K47/68; A61P19/08; A61P19/10; A61P35/00; A61P35/04; A61P43/00; C07K14/705; C07K19/00; C12N5/10; C12N15/62; C12P21/02; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita