Title:
DEVELOPMENT AND USE OF FLUORESCENT PROBES OF UNBOUND BILIRUBIN
Document Type and Number:
Japanese Patent JP2019146569
Kind Code:
A
Abstract:
To provide fluorescent probes of unbound bilirubin and to provide methods of use thereof.SOLUTION: Provided is a solid substrate to which a probe is attached, in which the solid substrate comprises polystyrene beads, latex beads, or Ni-agarose beads, and the probe is attached to the solid substrate, the probe having a specific amino acid sequence, and comprising an intracellular lipid binding protein (iLBP) comprising a His-tag at the C-terminus and a fluorophore attached to a specific site of the protein, and binding to bilirubin but not significantly binding to fatty acids.SELECTED DRAWING: None
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Inventors:
ALAN MARC KLEINFELD
ANDREW HENRY HUBER
JAMES PATRICK KAMPF
KWAN THOMAS
ZHU BAOLONG
ANDREW HENRY HUBER
JAMES PATRICK KAMPF
KWAN THOMAS
ZHU BAOLONG
Application Number:
JP2019043964A
Publication Date:
September 05, 2019
Filing Date:
March 11, 2019
Export Citation:
Assignee:
ALAN MARC KLEINFELD
International Classes:
C12Q1/00; C07K14/47; G01N33/53; G01N33/533; G01N33/72; G01N37/00
Domestic Patent References:
| JP2004506898A | 2004-03-04 |
Foreign References:
| US20100298162A1 | 2010-11-25 | |||
| US20050244864A1 | 2005-11-03 | |||
| US20100062948A1 | 2010-03-11 | |||
| US20090318299A1 | 2009-12-24 |
Attorney, Agent or Firm:
Akio Miyazaki
Masaaki Ogata
Masaaki Ogata