Title:
ANTI-MUC16 ANTIBODIES AND USES THEREOF
Document Type and Number:
Japanese Patent JP2021000132
Kind Code:
A
Abstract:
To provide anti-MUC16 antibodies and uses thereof.SOLUTION: Provided in the specification are compositions, methods, and uses involving antibodies that immunospecifically bind glycosylated forms of MUC16, which is a tethered mucin protein. Also provided in the specification are uses and methods for managing, treating, or preventing disorders, such as cancer. Provided are antibodies and antigen-binding fragments thereof, and polypeptides including such antibodies or antigen-binding fragments, such as fusion proteins, conjugates, and/or chimeric antigen receptors, as well as cells expressing the same.SELECTED DRAWING: Figure 1A-B
Inventors:
DAVID SPRIGGS
ALBERTO FERNANDEZ-TEJADA
DHARMARAO THAPI
ALBERTO FERNANDEZ-TEJADA
DHARMARAO THAPI
Application Number:
JP2020162274A
Publication Date:
January 07, 2021
Filing Date:
September 28, 2020
Export Citation:
Assignee:
MEMORIAL SLOAN KETTERING CANCER CENTER
International Classes:
C12N15/12; A61K35/17; A61K39/395; A61K45/00; A61K47/68; A61K51/10; A61P35/00; C07K9/00; C07K14/47; C07K14/725; C07K16/28; C07K16/30; C07K16/46; C07K19/00; C12N5/071; C12N5/0783; C12N5/10; C12N15/13; C12N15/62; C12N15/63; C12P21/02; C12P21/08
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita