Title:
キメラ受容体遺伝子およびこれを用いて形質転換した細胞
Document Type and Number:
Japanese Patent JP3643590
Kind Code:
B2
Abstract:
Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.
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Inventors:
Esher, Zelig
Schindler, Daniel
Wax, Tova
Gloss, Gideon
Schindler, Daniel
Wax, Tova
Gloss, Gideon
Application Number:
JP51673193A
Publication Date:
April 27, 2005
Filing Date:
March 18, 1993
Export Citation:
Assignee:
Yeda Research and Development Company Limited
International Classes:
C12N15/09; A61K31/70; A61K35/14; A61K35/17; A61K35/18; A61K39/395; A61K47/48; A61K48/00; A61P35/00; C12N1/00; C12N5/00; C12N5/10; C12N15/12; C12N15/13; C12N15/62; C12R1/91; C12N; (IPC1-7): C12N15/09; A61K31/70; A61K35/14; A61K39/395; A61K48/00; A61P35/00; C12N5/10
Domestic Patent References:
| JP2174681A | ||||
| JP2500329A |
Other References:
J.Exp.Med.,1989,Vol.170,p.481-497
J.Cell.Biochem.,1990,suppl.14B,p.70,CE112
The EMBO J.,1989,Vol.8,No.12,p.3651-3656
J.Cell.Biochem.,1990,suppl.14B,p.70,CE112
The EMBO J.,1989,Vol.8,No.12,p.3651-3656
Attorney, Agent or Firm:
Eiko Funahashi