変異した不活化IgG2ドメインおよびこれを組み込んだ抗CD3抗体

Title:

変異した不活化IgG2ドメインおよびこれを組み込んだ抗CD3抗体

Document Type and Number:

Japanese Patent JP3947570

Kind Code:

B2

Abstract:

The invention provides mutated IgG2 constant regions and anti-CD3 antibodies incorporating the same. Such antibodies specifically bind to the CD3 antigen on T-cells but induce reduced mitogenic response compared with otherwise identical antibodies bearing natural IgG2 constant regions. The antibodies can be used for treating disorders requiring immune suppression with fewer side effects than result from treatment with prior anti-CD3 antibodies.

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Inventors:

Saw, Jay Yun
Cole, Michael Es.
Anassetti, claudio

Application Number:

JP54266497A

Publication Date:

July 25, 2007

Filing Date:

May 19, 1997

Export Citation:

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