Title:
2-デオキシ-2-フルオロ-アラビノース誘導体の合成
Document Type and Number:
Japanese Patent JP3987306
Kind Code:
B2
Abstract:
A process for deoxofluorinating a C2-hydroxyl group of a furanose, includes: (a) mixing the furanose and a deoxofluorinating agent in a solvent to form a reaction mixture, and (b) heating the reaction mixture to greater than about 50 DEG C. The process provides deoxofluorinated products, such as 2-fluoroarabinoses, in yields of at least 80% of theoretical.
Inventors:
Gauri Sankar Ral
Application Number:
JP2001214168A
Publication Date:
October 10, 2007
Filing Date:
July 13, 2001
Export Citation:
Assignee:
AIR PRODUCTS AND CHEMICALS INCORPORATED
International Classes:
C07D307/20; C07H13/08; C07H5/02; C07H15/18; C07H19/04; C07H19/09; C07H19/19
Domestic Patent References:
| JP10504548A | ||||
| JP60116697A | ||||
| JP6501927A |
Foreign References:
| WO1999005157A1 |
Other References:
Maruyama T. et al,Synthesis of 9-(2-Deoxy-2-fluoro-β-D-arabinosyl)adenine Bearing a Selectivity Removable Protecting,Chem. Pharm. Bull.,1999年,Vol.47, No.7,966-970頁,(タイトルの続き)Group
Maruyama T. et al,Synthesis and Antiviral Activity of 6-Chloropurine Arabinoside and Its 2'-Deoxy-2'-fluoro Derivative,Chem. Pharm. Bull.,1996年,Vol.44, No.12,2331-2334頁
Maruyama T. et al,Synthesis, Antiviral, Antibacterial and Antitumor Cell Activities of 2'-Deoxy-2'-fluoropuromycin,Chem. Pharm. Bull.,1995年,Vol.43, No.6,955-959頁
Scharer, O. D. et al,A Designed Inhibitor of Base-Excision DNA Repair,J. Am. Chem. Soc.,1995年,Vol.117,10781-10782頁
Mikhailopulo, I. A. et al,A Novel Route for the Synthesis of Deoxy Fluoro Sugars and Nucleosides,Helvetica Chimica Acta,1999年,Vol.82,2052-2065頁
Maruyama T. et al,Synthesis and Antiviral Activity of 6-Chloropurine Arabinoside and Its 2'-Deoxy-2'-fluoro Derivative,Chem. Pharm. Bull.,1996年,Vol.44, No.12,2331-2334頁
Maruyama T. et al,Synthesis, Antiviral, Antibacterial and Antitumor Cell Activities of 2'-Deoxy-2'-fluoropuromycin,Chem. Pharm. Bull.,1995年,Vol.43, No.6,955-959頁
Scharer, O. D. et al,A Designed Inhibitor of Base-Excision DNA Repair,J. Am. Chem. Soc.,1995年,Vol.117,10781-10782頁
Mikhailopulo, I. A. et al,A Novel Route for the Synthesis of Deoxy Fluoro Sugars and Nucleosides,Helvetica Chimica Acta,1999年,Vol.82,2052-2065頁
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kazuo Yoshii
Takashi Ishida
Tetsuji Koga
Kazuo Yoshii