Title:
細管の自動組織学的類別
Document Type and Number:
Japanese Patent JP4452624
Kind Code:
B2
Abstract:
A method of grading tubules in a first histological slide image derives a second image of objects in the first image of objects in the first image with boundary characteristics corresponding to tubules. It also derives a third image of second objects in the first image having pixel value characteristic of fat and holes within tubules. It combines data from the second and third images to identify holes within tubules and determines the relative areas of holes as proportions of their tubules to provide ratios, individual tubule ratios and an overall ration for all holes and tubules collectively. The number of tubules containing appreciably sized holes is counted. Tubules are graded by thresholding based on individual and overall tubule/hole area ratios, tubule/object proportion, tubule number and number of tubule with appreciably sized holes. Thresholds are derived from image gradation by an appropriate medical expert.
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Inventors:
Geat Christel Marie
Vaga Margaret Jay
Dachsbury Paul Gerald
Vaga Margaret Jay
Dachsbury Paul Gerald
Application Number:
JP2004546146A
Publication Date:
April 21, 2010
Filing Date:
October 20, 2003
Export Citation:
Assignee:
QINETIQ LIMITED
International Classes:
G01N21/27; G01N33/483; G06F19/00; G06Q50/00; G06T1/00; G06T5/00; G06T7/00; G06T7/60; G06V10/28
Other References:
CHENG H D ET AL, "A parallel approach to tubule grading in breast cancer lesions and its VLSI implementation",COMPUTER-BASED MEDICAL SYSTEMS, 1991. PROCEEDINGS OF THE FOURTH ANNUAL IEEE SYMPOSIUM BALTIMORE, MD, USA 12-14 MAY 1991,1991年 5月12日,4TH,pages 322-329
Attorney, Agent or Firm:
Sadao Kumakura
Fumiaki Otsuka
Toshio Imajo
Takaki Nishijima
Fumiaki Otsuka
Toshio Imajo
Takaki Nishijima